Vivomedica Share Discussion Threads

[wallabybob] 27/3/2008 12:17

Hi gang, yeah shaun, not exactly dry, but oil so thick it needs enema treatment to move it. waste of f'ing space! keep smiling digger, at least I haven't got any money to average down so it's a no brainer. (No brains more like)

[shortlegs2] 24/3/2008 11:49

Hi Shaun nice to hear from you, it's been snowing here, I've no idea how the weather will go next or whats going to happen to VVM.
SL2

[shortlegs2] 13/3/2008 16:28

The news we need digger is of a partener to take us forward, if that comes we may yet make a profit.
SL2

[digger27] 13/3/2008 15:47

sl2 - I thought that over on SLN. Been waiting months for delayed news and share price dropping while being ramped on news soon. News came today and down it goes even further.
Just hope we don't follow suit if and when news comes here or I am done with shares forever.

[shortlegs2] 13/3/2008 14:50

Hi guys all quiet on the western front, need some news from vvm
SL2

[digger27] 13/3/2008 13:07

Ello ello bob... we are all having a well earned rest from this hot share action.

I'm another day nearer to bankruptcy and preparing to leave the country. Will re-enter as an illegal and then claim for all my sprogs that are scattered across Eastern Europe.

Take it BLR is still keeping you keen?

[wallabybob] 13/3/2008 12:47

Anybody home, how the hell are you all?

[digger27] 20/2/2008 16:19

Can't sympathise with you there mate especially as I had to make do with beans on toast and a cup of tea. Mind you I couldn't eat raw fish as am allergic to most seafood so it would probably see me off.

[digger27] 20/2/2008 15:47

Must be that CR beer or rum eh shaun. I bet you are missing the freezing fog over there?

[digger27] 20/2/2008 15:20

Your guess is as good as mine I'm afraid. I can sell 100k on line for a shade over 1p... but when I up it to 200k they offer .085p.

[z1gzag] 20/2/2008 14:49

350k Buy or Sell???

[digger27] 14/2/2008 10:34

Surely there has to be news soon if they presented in September or am I being too optimistic?

[4shorty] 14/2/2008 09:19

interesting article, lets hope we get some interested partners to take this to market.
4S

[pc4900074200] 13/2/2008 19:13

'Pdf' file?

JANUARY 4 2008 ISSUE 1288

CLINICA. World Medical Technology News.

VivoMedica's DrugPrint could save drug recall casualties.

Product recalls can make significant dents in a company's wallet and reputation. The impact is felt even more when millions of dollars have been invested in taking the product to market, as is often the case with big pharma. So is there a clinical research tool that can sift out these potentially problematic drugs before they hit the shelves? Tina Tan finds out from UK medical device company VivoMedica

Around 25-40% of all drugs in pre-clinical testing show some drug-induced cardio-toxic effects. Among these adverse effects is the prolongation of the QT interval, which, in turn, increases the risk of lethal arrhythmias such as ventricular tachycardia. Research into a number of high-profile cases in the 1980sand 1990s, where fatal drug-induced arrhythmias had led to the withdrawal of the drugs from the marketplace, has linked QT prolongation with the blocking of a potassium channel known as the hERG channel. As a result, current QT prolongation screening protocols incorporate an in vitro hERG assay. But with around 50-60 ion channels regulating the electrical activity of heart cells, a full picture of a drug's cardiac effects cannot be obtained just by looking at the activity of one ion channel, argues VivoMedica.
"Current animal models used in pre-clinical drug testing do not have the power to pick up the different features that indicate drug-induced arrhythmias," says CEO Peter Leyland. On the other hand, the patch-clamp test – the gold standard for studying the activity of different ion channels in cells – whilst capable of giving a high level of qualitative data, is a very expensive procedure that requires a highly-skilled electrophysiologist to perform it.
Enter DrugPrint, a tool developed by VivoMedica to identify cardiac effects of new therapeutic compounds. The system consists of a microelectrode array (MEA) amplifier, on which a layer of "live, beating" cardiac stem cells is cultured. When the cells are subjected to test compounds, changes in the electrical activity of the cells are recorded and analysed by the DrugPrint software, which forms the integral part of the system. Taking defence tech into healthcare The software technology originated from the labs of UK defence contractor QinetiQ. Under its previous incarnation as Zi Medical, VivoMedica, based in Sittingbourne, Kent had gained worldwide exclusive rights to the technology from QinetiQ in 2005 and developed it for healthcare applications. Combining QinetiQ's expertise in signal processing and algorithm design, the DrugPrint software is capable of processing "enormous quantities of data" generated from a single beat of the cardiac stem cells and deciphering the different cardiac effects induced by the drug. In doing so, a cardio-toxic profile – a "drug fingerprint" – of the therapeutic compound is created, said VivoMedica.

The company presented results from its in-house validation study of DrugPrint at the Safety Pharmacology Society (SPS) meeting in Edinburgh in September. Testing a number of known ion channel blockers (dofetilide, lidocaine, nifedipine and 4-AP) on embryonic rat heart cells, the study found that DrugPrint was able to identify changes induced by the different classes of compounds and discriminate between their varying modes of drug action. More importantly, the software was able to identify disruptions to normal rhythmic activity. "QT prolongation is not just a hERG problem, but also a problem with other ion channels," said Dr Simon Bryant, senior scientist at VivoMedica and lead investigator of the in-house validation study. "Rather than testing a drug on a single sodium or potassium channel, DrugPrint can test the effect of the compound on all these different channels in one experiment. It can do this cheaply and, moreover, produce the same high content data that you'd get from a patch-clamp test." Stem cell firms can benefit Mr Leyland told Clinica that the poster presentation at the SPS meeting had stirred significant interest – not only among the drug companies that could gain from a tool such as DrugPrint – but also from stem cell companies. "Drug companies use different animal models in preclinical testing and in our study we have used a rat model. But the one thing they want is to use human heart cells," said the CEO. There are several stem cell companies that have the capability of culturing cardiomyocyte stem cells but lack the capability of interpreting the information they could get from these cells – a gap that can be filled by DrugPrint. "People have 'wetware' but no analytical capabilities. DrugPrint is able to offer stem cell companies an opportunity to realise the potential of their technology," said Mr Leyland. As to VivoMedica's commercialisation strategy for DrugPrint, the company would initially adopt a fee-for-service model. However, it is also open to licensing the whole system to drug companies, in the case where they decide they want to test a substantial number of compounds in-house.
The firm is now looking for pharma partners to run external validation studies of DrugPrint. "No one is collecting data with this level of detail and [who also has] the capability of analysing it with this degree of discrimination," said Mr Leyland.
"Drug companies all want the screening to be done at an earlier stage of drug development and they don't want to spend too much doing it. To get it wrong could be very costly for them."

Online daily at www.clinica.co.uk

pc

[oneillshaun] 13/2/2008 18:36

Sorry guys, just sent it to you PC.

Thanks

[pc4900074200] 13/2/2008 18:04

Shaun if you have Adobe Acrobat 8.1.1 or up-grade to that, you
should be able to 'cut and paste' the 'pdf' file. [I can]

Or send the file to ..........................and I will have a go
and post it up here.

pc

[z1gzag] 13/2/2008 17:39

shaun,
What's the gist of it.

[shortlegs2] 13/2/2008 16:21

Would Shaun if I new your email.
SL2

[oneillshaun] 13/2/2008 14:35

Morning all 8.37am and i have just got in.

I have some info on VVM that I would like to post, can someone tell me how to post a pdf file?
or even easier if you want to see it ping me an email.