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VRP Verona Pharma Plc

55.00
0.00 (0.00%)
Last Updated: 00:00:00
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Verona Pharma Plc LSE:VRP London Ordinary Share GB00BYW2KH80 ORD 5P
  Price Change % Change Share Price Shares Traded Last Trade
  0.00 0.00% 55.00 0.00 00:00:00
Bid Price Offer Price High Price Low Price Open Price
45.00 65.00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
  -
Last Trade Time Trade Type Trade Size Trade Price Currency
- O 0 55.00 GBX

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Verona Pharma Forums and Chat

Date Time Title Posts
07/1/202514:05Verona Pharma: Developing first in class drugs for respiratory diseases1,576
30/10/201808:41Still time to look at Verona Pharma (VRP)-
01/8/201809:42Verona Pharma (VRP) One to Watch -
16/2/201517:30Verona Pharma with Charts & News11,549
24/11/201112:54verona pharma173

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Posted at 02/1/2025 15:31 by tradertrev
Jefferies, who have a TP of $50, put out a note just before Christmas detailing feedback from pulmonologists they had surveyed about their prescribing experience with Ohtuvayre. Jefferies said this feedback suggested a peak US market share of 18% compared to their working assumpation of $1.5bn peak sales being less than 1.5% market share. Caveat to my considerable excitement about this is that the feedback sample is very small - only 8 doctors.
The note also mentions the company's plan to pre-announce Q4 sales in January. I've now had that from two sources.
Posted at 04/11/2024 13:59 by haroldthegreat
Verona Pharma plc
Mon, November 4, 2024 at 7:00 AM GMT 8 min read


In This Article:
VRNA
+3.09%
Ohtuvayre™ (ensifentrine) launch recorded Q3 net sales of $5.6 million and October net sales exceeded Q3

Through October more than 2,200 unique prescribers and more than 5,000 prescriptions filled across a broad COPD population

Pipeline expansion continues: Phase 2 programs enrolling

Conference call today at 9:00 a.m. ET / 2:00 p.m. GMT

LONDON and RALEIGH, N.C., Nov. 04, 2024 (GLOBE NEWSWIRE) -- Verona Pharma plc (Nasdaq: VRNA) (“Verona Pharma” or the “Company”;), a biopharmaceutical company focused on respiratory diseases, announces its financial results for the third quarter ended September 30, 2024, and provides a corporate update.

“We are pleased to report an exceptionally strong start to the US launch of Ohtuvayre (ensifentrine) with healthcare professionals (HCPs) prescribing treatment across a broad range of chronic obstructive pulmonary disease (“COPD”) patients including background single, dual and nearly 50% on triple therapy,” said David Zaccardelli, Pharm. D., President and Chief Executive Officer. “While it is still very early in the launch, we are extremely encouraged from the initial patient and HCP reports about Ohtuvayre’s potential to improve COPD symptoms regardless of COPD severity. This broad utilization across all patient types is consistent with market research and supports our belief that Ohtuvayre’s bronchodilator and non-steroidal anti-inflammatory activity is a significant advancement for COPD patients and can re-define the treatment paradigm.

“In the third quarter, through the first seven weeks of launch, we recorded $5.6 million of net sales. We are excited by the continued acceleration as net sales for October exceeded the third quarter. More than 5,000 Ohtuvayre prescriptions were filled and more than 2,200 unique HCPs prescribed Ohtuvayre in just 12 weeks.

“Alongside our successful Ohtuvayre launch, in the third quarter we initiated two Phase 2 clinical trials: a dose-ranging trial with glycopyrrolate, a long-acting muscarinic antagonist (“LAMA”), supporting a nebulized fixed-dose combination program with ensifentrine for the maintenance treatment of COPD, and a trial assessing the efficacy and safety of nebulized ensifentrine in patients with non-cystic fibrosis bronchiectasis (“NCFBE”).”

Third Quarter and Recent Highlights

In August 2024, the Company launched Ohtuvayre for the maintenance treatment of COPD in the US.

During the third quarter of 2024, the Company began enrollment in two new clinical programs:

Phase 2 dose-ranging trial with glycopyrrolate, a LAMA, supporting a fixed-dose combination program for the maintenance treatment of COPD via a nebulizer.

Phase 2 trial to assess the efficacy and safety of nebulized ensifentrine in patients with NCFBE.

Following the end of the third quarter, the Company received notification from the Centers for Medicare & Medicaid Services that its permanent, product-specific J-code for Ohtuvayre, J7601, has been accepted and will be effective January 1, 2025.

The Company recently presented additional analyses of data from the Phase 3 ENHANCE trials with ensifentrine for the maintenance treatment of COPD at the European Respiratory Society International Congress 2024 and at CHEST Annual Meeting 2024 (“CHEST”). Approximately 1,500 HCPs visited Verona Pharma’s medical and commercial booths for Ohtuvayre at CHEST.

In September 2024, the Company’s development partner in Greater China, Nuance Pharma, completed enrollment in its pivotal Phase 3 clinical trial evaluating ensifentrine for the maintenance treatment of COPD in China. Results from the trial are expected in 2025.

Third Quarter 2024 Financial Results

Cash position: Cash and cash equivalents at September 30, 2024 were $336.0 million (December 31, 2023: $271.8 million). The Company believes cash and cash equivalents at September 30, 2024, along with product sales and funding expected to become available under the $650 million strategic financings completed in May 2024, will enable Verona Pharma to fund planned operating expenses and capital expenditure requirements through at least the end of 2026.

Product sales: Net sales were $5.6 million for the third quarter ended September 30, 2024 (Q3 2023: $0 million) related to product sales of Ohtuvayre. The Company received FDA approval on June 26, 2024 and the product was commercially available beginning in August 2024.

Cost of sales: Cost of sales was $0.5 million for the third quarter ended September 30, 2024 (Q3 2023: $0 million), which included Ohtuvayre manufacturing costs incurred after US approval, inventory overhead costs and sales-based royalties due to Ligand.

R&D Expenses: Research and development (“R&D̶1;) expenses were $10.6 million for the third quarter ended September 30, 2024 (Q3 2023: $3.0 million). This increase of $7.6 million was primarily due to an $7.8 million increase in clinical trial and other development costs as we initiated two Phase 2 trials in the quarter.

SG&A Expenses: Selling general and administrative expenses (“SG&AR21;) were $35.2 million for the third quarter ended September 30, 2024 (Q3 2023: $13.4 million). This increase of $21.8 million was driven primarily by a $9.7 million increase in people-related costs and $2.8 million in share-based compensation primarily related to our field sales team, which was hired in the lead up to the launch of Ohtuvayre. Additionally, marketing and other commercial related activities, including travel, increased by $7.5 million due to the launch. We also had an increase of $1.6 million related to professional and consulting fees, information technology costs and other support costs due to the continued build-out of our commercial organization.

Net loss: Net loss was $43.0 million for the third quarter ended September 30, 2024 (Q3 2023: $14.7 million).
Posted at 21/10/2024 11:48 by haroldthegreat
Ohtuvayre, a COPD maintenance treatment, costs $2,950 per month, or $35,400 per year:
This price is almost three times higher than the Institute for Clinical Economic Review's (ICER) recommended valuation range of $7,500 to $12,700 per year. ICER is a non-profit that evaluates drug prices based on their health benefits and risks.

I wonder what the co-pay is ?
When was the drug launched in USA ?
Posted at 01/1/2024 22:50 by haroldthegreat
thank you Tim for the share chart.
Posted at 09/5/2023 10:44 by tradertrev
Cash and equivalents have risen from the $285m (pro-forma that included ATM issuance up to 3rd March 2023) at 31st December 2022, to $291m as at 31st March 2023. This suggests that further ATM issuance of $6m above Q2 cash costs (i.e. a total of $20m, or roughly 1m ADRs) were issued under the ATM facility between 3rd and 31st March 2023.
This could explain some relative sluggishness in the share price over that period.
There is no mention of ATM issuance in today's statement in relation to both the total cash and equivalents and the liquidity available to last until at least the end of 2025. This suggests to me that they may have stopped issuing further shares under the ATM facility, at least for the time being.
This could help the shares move on a bit.
Posted at 07/2/2023 07:04 by tradertrev
The graph shows that the price has fallen back after a barnstormingly good year. Yesterday's rise is very close to breaking the short term downtrend.
Don't understand your unchanged expectations Haff. Maybe holding the chart the right way up would help?
Posted at 06/2/2023 09:58 by haff1
Not good from a TA perspective: lowering highs and lowering lows....the graph is indicating a fall!! So no change in VRP expectaions....
Posted at 22/12/2022 08:53 by tradertrev
Harold - not hard facts, but I seem to recall that if you went back far enough on old UK charts you would see the equivalent of at least £20 per UK share. This was diluted many times by share issuance at ever decreasing prices. £20 per UK share would be the equivalent now of $133 per ADR (8 shares per ADR), although at more normal exchange rates back then (say $1.50) it would be more like $107.
I suspect this is all rather academic however.
Posted at 20/12/2022 10:59 by timbo003
I'll settle for that, not quite as good as ENHANCE2, as they just missed out on significance for reduction in exacerbation rate, but they are good enough, especially when you combine the data from the two studies and bingo, Clinically menaingful statistical significant reductions in exacerbations which everway you look at it

I predict a blue day for the share price
Posted at 09/8/2022 18:48 by haroldthegreat
Tim perhaps you should remove the LSE VRP charts ? Looks like that the shares have flat lined . Today they have been given a shot of Viagra but like Viagra the effect on the share price is waning after a few hours !
Verona Pharma share price data is direct from the London Stock Exchange

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