Trellus Health Share Discussion Threads

[adobbing] 05/1/2022 13:43

Thanks Aspringo.
Mine are sat in an ii account, like yours they show £0 value.
Not exactly a large value, but I like to today these things up!

[aspringo] 05/1/2022 12:31

adobbing, I also wondered, as they are sitting as an entitlement with zero value in my barclays account.I know wan is knowledgeable on these as he did answer once before.Unfortunately this past year has been a year of upset, and I can't remember exactly what he said.I'm sure barclays know what they're doing, haha.All the best for a better year.

[adobbing] 04/1/2022 12:51

So I’m guessing that the date the “Lock up” would end, would be on or around 28/5/22 as that will be a year since trading of TRLS commenced?

[adobbing] 23/12/2021 10:32

Question around In Specie shares from EKF.
Below is from the Corporate action on EKF dated 24/12/20.
When do these become available, is it tomorrow or longer?

Terms: 1 A share in Trellus Health Limited for every 16.25 EKF Diagnostics Holdings plc shares held
Ex-entitlement date: 16th December 2020
EKF Diagnostics Holdings plc has announced a distribution in specie, whereby holders will be issued with 1 A ordinary
share in Trellus Health Limited for every 16.25 existing shares in EKF Diagnostics Holdings plc held. The ex-entitlement
date is 16th December 2020.
EKF Shareholders will become the beneficial owners of their respective Dividend Shares upon completion of the
transfer of the Dividend Shares to Broadway Nominees Limited, at which time an `omnibus` share certificate in
respect of the Dividend Shares will be issued and held by Broadway, to be held on trust by it on behalf of the Relevant
EKF Shareholders for a period of 365 days following admission to trading on AIM (or another recognised stock
exchange) of the issued share capital of Trellus; or if the issued share capital of Trellus is not admitted to trading on
AIM (or another recognised stock exchange) within two years of the date that the Dividend is settled, two years from
the date that the Dividend is settled. During the Lock-up Period, Relevant EKF Shareholders will not be permitted to
transfer the legal or beneficial ownership of their Dividend Shares. The A Shares will, on the earlier of the admission to
trading of Trellus on AIM (or another recognised stock exchange) and two years from the date that the Dividend is
settled, automatically convert into ordinary shares in Trellus on the basis of one Ordinary Share for each A Share held.
If Trellus is admitted to trading on AIM (or another recognised stock exchange), the Lock-up Period will continue to
apply to the converted Ordinary Shares. All converted Ordinary Shares will rank equally in all respects with all other
Ordinary Shares including in respect of voting and dividend rights. The legal title to the Dividend Shares will be held by
Broadway as trustee, during the Lock-Up Period. If the A Shares are converted into Ordinary Shares during the Lock-up Period, Broadway will request that Trellus` registrar seeks the voting instructions of the Relevant EKF Shareholders in relation to any shareholder resolution of Trellus and will vote those Dividend Shares in accordance with such instructions as it receives.

[brummy_git] 22/12/2021 11:18

Christopher Mills talks positively about Trellus Health (55:50) here.

www.linkedin.com/feed/update/urn:li:activity:6879354290515841026/

www.youtube.com/watch?v=cG7_82WZdmc&t=2135s

[mikemine1] 19/12/2021 03:07

A good podcast. In line with lots of companies, covid has hindered progress from TRLS's stated path but things are still on track. Just a bit late. I don't think it will materially affect the longer term ambition of commercialisation. Interest is still strong and, as far as I can see, competition is virtually non-existent.

IMHO, the reaction to the reported delay is well over done and the price is very attractive for a medium to long term investment.

[brummy_git] 15/12/2021 09:57

Terrific comments here wrt yesterday's trading update from CEO Monique Fayad
of Trellus Health

www.voxmarkets.co.uk/articles/q-a-with-trellus-health-ceo-monique-fayad-fd062cf

[senttothegallows] 15/12/2021 08:29

Price down at these levels is absolute insanity amazing how difficult they are to buy given how it has been walked down. Expecting a big bounce IMHO

[cambridgedon] 14/12/2021 10:43

Thanks Wan.
Seems that the RENX and TRls share prices are suffering at the same time! In one sense they both represent a lot lower risk than at the IPO/launch price but the recent falls have also got many to question what they are really worth. Thoughts?
CD

[wan] 14/12/2021 10:15

CD...The issue/IPO price per Trellus Share was 40 pence.

[cambridgedon] 14/12/2021 09:40

Can someone remind me what the IPO price was.
Thanks,
CD

[brummy_git] 14/12/2021 08:17

Find out all the news & commentary here wrt Trellus Health's trading update today.

www.linkedin.com/posts/paul-hill-a5994116_trls-trls-activity-6876434026043912192-JMdo

[wan] 14/12/2021 07:52

A welcome update today. And what sounds like a very promising 2022 ahead, starting as early as Q1 with several B2B payer contracts in late-stage negotiations with expected completion in Q1 2022.

With regard to my kidney disease food for thought post above, the license from Mount Sinai includes kidney disease. I previously confirmed that the disease categories beyond IBD that are covered by Trellus Health's license from Mount Sinai include: cancer, heart disease, diabetes, kidney disease, autoimmune diseases, COPD and Cystic Fibrosis.

[wan] 10/12/2021 09:44

Trellus Health is starting with IBD, but ultimately they are targeting coordinating and connecting multidisciplinary care for complex chronic conditions. So, the following is just food for thought (and we know where some of there stablemates are focused) -

Many Upsides for Telemedicine in Chronic Kidney Disease
Pam Harrison

December 07, 2021

Patients with chronic kidney disease (CKD) who receive treatment through video-based telemedicine consults have acceptable, if not comparable, clinical outcomes, generally fewer emergency room (ER) visits and hospitalizations, and improved efficiencies compared with those treated in person, a new review indicates.

Moreover, levels of patient satisfaction with telemedicine are uniformly high, the same study shows.

"The nature of CKD care makes it particularly amenable to virtual care given that relevant history, review of laboratory investigations, and counseling can all be conducted via virtual platforms," Ann Young, MD, PhD, University Health Network, Toronto, Ontario, Canada, said in a statement issued by the American Society of Nephrology.

"The main obstacle of virtual care is the lack of a physical exam [so] finding the appropriate balance between virtual visits and in-person visits is key," she added.

Many Benefits of Telehealth but Beware the Digital Divide
However, senior author, Stephanie Ong, BScPhm, MSc, also of the University Health Network, cautioned that the "digital divide" must be considered when assessing the use of telemedicine.

"[These results] are encouraging but as the latest technologies are streamlined into routine healthcare, the 'digital divide' will become more pronounced, negatively impacting those without access to broadband internet connections, video-capable devices, and those with limited technology literacy," she noted in the ASN statement.

"This is an area that deserves further study," she advised.

And in an accompanying editorial, Susie Lew, MD, and Neal Sikka, MD, both from George Washington University in Washington, DC, agree with Ong that the ability to effectively use a device such as a computer or a smartphone is a challenge for some patients who may have low health literacy.

On the other hand, they acknowledge the many benefits of telehealth. "Patients can benefit from access to their care providers, receive multidisciplinary care, include distant relatives in visits, and have the convenience of staying at home," they write. A visiting nurse could also participate in a home care visit and lab draws can be done in the local community.

"For those that are skeptical about telehealth, we feel that a telehealth visit is better than no visit at all for a new or existing patient," Lew and Sikka observe. "[And we believe that telehealth] has clearly become another useful tool for clinicians and patients attempting to increase touchpoints and simplify care delivery."

And in a Patient View published alongside the review and editorial, patient Julie Glennon, of West Palm Beach, Florida, notes that she has suffered from CKD for over three decades and has been on dialysis multiple times.

"There have been many times in my past that a telehealth visit would have been incredibly helpful," she writes, noting that whenever she went into kidney failure, she was very ill. "Gathering the strength to get dressed and drive to my doctor's office was a monumental feat [during those times]," she admits.

Patients who live in rural communities or those with mobility issues can also benefit from a virtual visit, which can help eliminate the stress of having to get to their physician's office, Glennon explains.

However, "there are times when physically going into a doctor's office or imaging facility is necessary," Glennon acknowledges. Nevertheless, she feels that the quality-of-care she received during a virtual visit was equal to the care she would get in a doctor's office. Virtual visits also save time, money, and energy.

"The high patient satisfaction and acceptable clinical outcomes cited in the CJASN study should encourage continued telehealth support and options," Glennon concludes.

Review Included 24 Studies on Telemedicine vs In-Person Care
Young and colleagues reviewed 24 studies across 10 countries that were published between 1997 and 2020. The studies included seven in patients with CKD, eight in patients on dialysis, and eight in kidney transplant recipients.

Earlier studies primarily reported on the use of institution-specific technologies linking main hospital sites to more remote healthcare locations.

However, more recent studies connected patients — often from their own homes — to their nephrologists using web-based video-conferencing solutions on personal devices with a microphone and webcam.

Across the seven studies that used video-based telemedicine for patients with CKD, there were few differences in reported clinical outcomes, need and timing of dialysis, change in kidney function or blood pressure, or other biochemical markers relative to in-person care.

Moreover, "ER visits and hospitalizations were no more frequent in the telemedicine group compared to in-person care," the investigators note, "and all studies reported improved efficiency with telemedicine, including a reduction in the waiting time to see a specialist, fewer clinic cancellations, [and a] reduction in travel time and distance traveled."

Over 95% of patients also expressed high levels of satisfaction with telemedicine, most noting that the care received was the same level as the care they got being seen in person.

For patients on dialysis who received video-based care, reported clinical outcomes were similar if not better than they were for patients treated in-person. They had fewer ER visits and hospital admissions than those receiving in-person care.

Also, among kidney transplant recipients, clinical endpoints were equal among patients receiving video-based telemedicine compared with those who received in-person care. Hospital admissions were lower in telemedicine patients in one study, although another study reported higher rates of ER visits and hospitalizations after receiving a video-based transplant follow-up.

Full article -

[wan] 10/12/2021 08:01

'Quietly' things are happening/evolving. I note at least two new hires with Tyler Martin previously hailing from Optum which is a subsidiary of UnitedHealth Group which is the world's eighth largest company by revenue and second-largest healthcare company behind CVS Health by revenue-

Tyler Martin
Chief Strategy O​fficer

Former SVP, Strategic Growth & Development, Optum
Former VP, Strategy & Development, Healthgrades
Former Executive Director, Children’s Hospital Colorado
Former Bain & Company Consultant
Developed & launched multiple businesses across healthcare, media & retail, scaling operations and growth for long-term sustainability and competitive advantage


Susan Rose
Financial Controller

Former management at Kindred Healthcare, Inc., and other healthcare organizations


According to Wikipedia, Kindred Healthcare is a post-acute healthcare services company that operates long-term acute-care hospitals and provides rehabilitation services across the United States.

Kindred's headquarters and support center are located in Louisville, Kentucky.[3]

As of March 2018, Kindred Healthcare had approximately 38,300 employees in 45 states and approximately $3.4 billion in annual revenues.

[wan] 04/12/2021 06:42

Trellus Health mentioned/tipped in the following article -

UK life sciences investing – High rewards but also high risk
Analysis
2 DEC 2021
Lawrence Gosling

This has driven investors, many non-specialists, into these high- profile opportunities. But the UK biotech sector has a troubled past, and to inform a view of the current market we take three case studies to illustrate how things can go wrong for investors in this sector. We’ve contrasted each of these with more recent examples of how things have changed and what we would categorise as high-quality, well-validated opportunities.

There are still crazy ideas on the market, but the type of opportunities we are drawn to are those with sufficient validation to convince us that risks are suitably managed, and where the products will make a real difference to patients.

Companies coming out of the Mount Sinai hospital system in New York are a good example. The founding intellectual property, the core idea of companies such as Renalytix, Verici Dx and Trellus Health, has been tried and tested in real-world clinics and there is a tangible benefit to patients.

Renalytix and Verici Dx are developing diagnostics, which are generally lower-risk than drug development. Importantly, these companies are augmenting diagnostic testing with data and machine learning. In the case of Renalytix, a machine learning algorithm is used to combine blood biomarkers of disease and data from a patient’s electronic health record to prognosticate a risk score for kidney failure.

The success of Renalytix’s approach in an area of little innovation is clear to see.

Verici Dx understands the power of data to elevate the utility of testing. It plans to build a data repository of whole genome sequences of patients that pass through its trials and use its products. This may not be leveraged immediately but being able to use this database either for discovery of new biomarkers or to boost test performance is an exciting prospect.

Full article, What Investment -

[wan] 12/11/2021 09:58

Whilst we patiently wait for the number of demonstration projects to expand during the remainder of 2021 (precise timing could of course change or slip), potentially involving several hundred patients in aggregate. I caught up briefly, amongst other things, with an enquiry regarding the disease categories beyond IBD that are covered by Trellus Health's GRITT license from Mount Sinai. I can confirm that these include: cancer, heart disease, diabetes, kidney disease, autoimmune diseases, COPD and Cystic Fibrosis.

I wanted to get this confirmed as Trellus Health considers its approach to have potential utility and demand across many chronic conditions. And the Directors estimate that chronic and mental health conditions and IBD, represent over $3 trillion and $30-50 billion in total annual costs in the US, respectively. So, IBD is potentially a very large market on its own (hence pharma interest), but obviously there is a collectively even larger market to go after too for other chronic conditions, and with IBD providing the proving ground, there will be a medium-term opportunity to replicate the approach to other chronic conditions.

There is a lot pharma interest in this area, and it should not be overlooked that
clinical disease management and monitoring approach is also an integral part of Trellus Health's approach. So, I would also like to see at least one pharma collaboration materialise for IBD in the not too distant future. For which I believe discussions are live/active, with Julian Baines, Non-executive Chairman of Trellus recently stating (in Half-year Report) that -

“We are also very pleased with the progression of our dialogue with large organisations outside of health plans and employers, including those within the pharmaceutical industry, who have recognised the potential value of our platform to support their goals, as well as third parties interested in applying our methodology to other illnesses.”

[melody9999] 04/11/2021 09:41

thanks - would be grateful for any latest insights

[hastings] 04/11/2021 09:39

Spoke with the CEO last week and well worthwhile, but haven't got round to penning anything yet. Hopefully I'll get on to it next week.

[melody9999] 04/11/2021 09:31

any reason for the share price dip? Hastings - anything to report?

[wan] 03/11/2021 08:07

The following provides for an insightful read regarding the current and future growth in telehealth -

AWS physician expert talks new use cases for telehealth, machine learning, cloud

Dr. Rowland Illing, director of international public sector health at Amazon Web Services, offers a tutorial on some leading-edge technologies, and how they're being deployed across healthcare.

By
Bill Siwicki
November 02, 2021

During the COVID-19 pandemic, telehealth and remote monitoring have found their place in routine clinical practice like never before. According to a study published by the Journal of the American Medical Informatics Association, during the pandemic, telehealth services for urgent care have grown by 683% and by 4,345% for non-urgent care.

Q. You mentioned earlier the growth of telemedicine that has taken place during the COVID-19 pandemic. Given the expansion of these services and the ability of patients to seek care anywhere around the world, does this make the issue of interoperability even more pressing?

A. Indeed, the changes have been profound. Over the last 18 months, Brazil has legalized the use of telemedicine, and Australia has made telehealth a part of the national health service going forward.

The Indian government built the eSanjeevani telemedicine platform on AWS in 19 days across four states, free to patients and available 12 hours a day, seven days a week.

This pilot was such a success that it was scaled up to cover all of India, enabling more than one billion people to seek virtual care – 80% of the Indian population. It now provides more than 6,000 consultations a day across 23 states, involving 4,000 doctors in 150 outpatient clinics.

Full article -

[wan] 27/10/2021 16:39

Thank you Hastings, I look forward to that!

[hastings] 27/10/2021 15:56

Speaking with the CEO tomorrow pm and will endeavour to put something together that will hopefully be of use!

[wan] 27/10/2021 10:01

When my own research (prior to Trellus listing) revealed how many large (and small) Pharma's were actively working on addressing different aspects of IBD (with some nearing FDA approval), combined with how Trellus plan to enter strategic industry partnerships with pharmaceutical companies to leverage its proprietary, anonymised longitudinal database to develop new products and inform clinical trials for existing and prospective drug treatments etc, it added to my rationale to significantly increase my investment in Trellus over and above my EKF in specie shares(via application and early market purchases).

I also find it reassuring that EKF, via ADL Health, could quickly provide any crucial/complimentary biomarker testing in the US for Trellus Health via their CLIA approved laboratory. Indeed, EKF highlighted the potential in their Growth Strategy for any CLIA lab purchase for diagnostic tests to link to Trellus, Renalytix and Verici.


Now part of the EKF Diagnostics Group