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Share Name | Share Symbol | Market | Type | Share ISIN | Share Description |
---|---|---|---|---|---|
Tiziana Life Sciences Plc | LSE:TILS | London | Ordinary Share | GB00BKWNZY55 | ORD 3P |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 58.50 | 45.00 | 60.00 | - | 0.00 | 01:00:00 |
Industry Sector | Turnover | Profit | EPS - Basic | PE Ratio | Market Cap |
---|---|---|---|---|---|
0 | 0 | N/A | 0 |
Date | Subject | Author | Discuss |
---|---|---|---|
12/1/2022 19:38 | The faithful certainly do come out of the woodwork at the most opportune time...A serial shorter, hmmm!...If that's how good your analysis is Lean then it doesn't really bode well for ones investing/trading aptitude, oops! | one_frankel | |
12/1/2022 19:34 | The Rebel was invested except he came to the conclusion that the BoD were flaffing around and not to be trusted...Has it been real struggle to realise thus far? | one_frankel | |
12/1/2022 18:23 | There's making mistakes and 'Making Mistakes' Puff! ...By the way, I'm meticulous so as a consequence one could state Ol'WiseOne!...But unfortunately I still await the billionaire status, not long to go now! | one_frankel | |
12/1/2022 17:42 | You seem to be a paid troll ? | jpuff | |
12/1/2022 17:39 | Why do you continue to lurk on this board if you're not a shareholder and can't think of anything positive? It seems odd? Do you just get pleasure out of rubbing PI's noses in it and gloating at how so bloody wonderful you are? | jpuff | |
12/1/2022 17:38 | Thank you oh wise one who never makes mistakes and is a billionaire as a result?! | jpuff | |
12/1/2022 16:56 | A 'Minor Miracle' Puff, hehe!...Not like you to make such a nonsensical statement! ...I'm sorry but I have no sympathy for investors here, the alarms bells had been ringing for a significant period of time if they hadn't been so bloody blinkered! | one_frankel | |
12/1/2022 16:43 | Very much smells of an orchestrated pump and dump this saga. It even seems to me that the company itself went along with it given their carefully timed press releases and huff and puff at the time. The whole mob probably got the signal to go short the shares just at the time innocent private investors were buying! An utter disgrace and a prime example of what's wrong with AIM and the U.K. stock market and capitalism at its worst. | jpuff | |
12/1/2022 16:29 | I know what you mean Michelle, it's been an awful experience for us all and to be honest I wish I'd never come across this company now. It may come good or even be bought out so I remain hopeful. However, realistically we need a minor miracle now it seems | jpuff | |
12/1/2022 15:35 | I can't look just need something good to come from this | michelle74 | |
12/1/2022 13:54 | So it's basically been a negative ten bagger from the hyped up (pump n dump) peak. May see some stability now hopefully or a consolidation (bad news again) or final curtains / taken private. Let's see! | jpuff | |
12/1/2022 13:52 | The current price today of tlsa is showing as 85 cents so converted to old TILS that's 31p | jpuff | |
10/1/2022 18:03 | They rely on test results from.... 'one' patient, sorry, two now, for this to go to market after positive trials?..What am I naivily missing here. The flim 'Dont look up' is entering my thought processes at the moment..Btw.. Thankfully, I do not hold any tils shares..... Perplexing to say the least. | lean5gb | |
10/1/2022 14:36 | A bit better news for you ABBYNAT, judging books and covers come to mind! | stenick | |
10/1/2022 13:39 | TILS get a lot of stick on here but I think this feels like a multi-bagger. | david gruen | |
10/1/2022 13:32 | Tiziana Enrolls Second Patient in Ongoing Intranasal Foralumab Evaluation for Secondary Progressive Multiple Sclerosis10 January 2022- Clinical data from the first patient, after completing 3 out of 6 months, suggest that the treatment was well tolerated with a favorable clinical response- FDA allows for continued enrollment under the Individual Patient Expanded Access ProgramNew York, January 10, 2022 Tiziana Life Sciences (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company enabling breakthrough immunotherapies via novel routes of drug delivery, is pleased to announce that the U.S. Food and Drug Administration (FDA) allowed enrollment of a second patient in the ongoing clinical treatment of secondary progressive multiple sclerosis (SPMS) with intranasally administered foralumab, a fully human anti-CD3 monoclonal antibody, at the Brigham and Women's Hospital (BWH), Harvard University, Boston, MA.Dr. Kunwar Shailubhai, Chief Executive Officer of Tiziana noted, "We have been systematically building a database of evidence to support both the safety and clinical potential of intranasal and oral forms of foralumab in close collaboration with the FDA, and during 2022 plan to initiate several new trials across areas of large unmet need, including MS, Crohn's Disease, and Type 1 Diabetes. Today's update marks important progress in the advancement of our MS program, and supports our novel approach to provide local, rather than systemic delivery of antibodies."The first patient treated under this program completed 3 out of 6 months of dosing. Interim data suggest that the treatment was well-tolerated with a favorable clinical response. As part of the regulatory process, three-month safety data were submitted to the FDA, seeking permission to treat an additional patient under an Individual Patient Expanded Access Investigational New Drug Application (IND), which has been allowed. Treatment of the second patient is expected to begin during January 2022 with interim clinical data after 3 out of 6 months of treatment expected in April 2022. The treatment plan will remain unchanged as per the original IND. The Investigators at BWH will be monitoring detailed safety, neurological, and Positron Emission Tomography (PET) to evaluate microglial activation in this patient. Modification of immunological and neurodegenerative markers will also be included as part of the standard investigation to be conducted by BWH.The ongoing treatment of the first patient continues, and six months of dosing is expected to be completed by the end of March 2022. To date, this patient has not shown signs of treatment intolerance or toxicities and appears to be responding well to treatment. The brain imaging data, as analyzed by PET, show reduction in microglial cell activation. Published PET studies have shown an increase in activated microglial cells in patients with SPMS, and that their increased presence in the brain is associated with higher scores on the Expanded Disability Status Scale (EDSS), a scale that is widely used to assess cognitive disability1. Consistent with these findings, Tysabri® (natalizumab) (NASDAQ: BIIB), an approved drug for treatment of MS, is also believed to act via reduction in microglial activation.Howard Weiner, M.D., Director of the Multiple Sclerosis Program at BWH and Chairman of Tiziana's Scientific Advisory Board, commented, "The potential for intranasally administered foralumab to suppress microglial activation is a promising and novel approach to provide a potentially safe treatment of SPMS that currently has no effective treatment. We are extremely pleased with the tolerability of the treatment seen to date as well as with the positive clinical responses observed after completion of three months of dosing in the first patient, and we look forward to clinical data after completion of six months of treatment."Tanuja Chitnis, M.D., Principal Investigator and Professor of Neurology at Harvard Medical School and senior neurologist at BWH and Massachusetts General Hospital added, "New treatments for progressive MS are urgently needed. Intranasal foralumab could revolutionize treatment for this disabling form of disease."About ForalumabForalumab (formerly NI-0401), the only entirely human anti-CD3 mAb, shows reduced release of cytokines after IV administration in healthy volunteers and in patients with Crohn's disease. In a humanized mouse model (NOD/SCID IL2?c-/-), it was shown that whilst targeting the T cell receptor, orally administered foralumab modulates immune responses of the T-cells and enhances regulatory T-cells (Tregs) and thus provides therapeutic benefit in treating inflammatory and autoimmune diseases without the occurrence of potential adverse events usually associated with parenteral mAb therapy (Ogura M. et al., 2017. Clin Immunol.183:240-246) | ic0gcds00 | |
09/1/2022 17:02 | Hi Marshsi, i consider myself one of the lucky shareholders, im perhaps 4k down which isn't really much considering, I sold out on the way down. It really does burn a hole in my eyes when i see this worthless junk.... | fandagle | |
09/1/2022 14:45 | I wonder if Accustem will ever be listed other than OTC....... it seems odd that a British court allow these people to steal shareholder assets? | nerdofsteel | |
09/1/2022 12:57 | How much are we talking Fan? I think I’m just going to let my bank sell the shares for close to a four figure loss | marshsi | |
08/1/2022 09:04 | These damn Accuscam shares are clogging up my profile, every time i logon it reminds me of how much money ive been swindled out off by these crooks.... | fandagle | |
07/1/2022 05:36 | AJ Bell or Interactive Investor can both hold Tiziana shares for you. | jpuff | |
06/1/2022 23:50 | So first direct contacted me today to say they are going to sell my shares on 12th January unless I move them to another broker. 5 days notice! Which brokers are decent for TILS or is it time to cut my losses and let them go? | marshsi | |
05/1/2022 08:04 | Elizabeth Holmes Found Guilty of Four Charges of Fraud - It may be a labelling fraud, but lets hope this shower of crooks get investigated at some point on a variety of anomalies.......Go to jail for 60 years! Do not collect any more hard earned shareholders cash! | fandagle |
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