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| Share Name | Share Symbol | Market | Stock Type |
|---|---|---|---|
| Tiziana Life Sciences Plc | TILS | London | Ordinary Share |
| Price Change | Price Change % | Share Price | Last Trade
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|---|---|---|---|---|
| 0.00 | 0.00% | 58.50 | 01:00:00 |
| Open Price | Low Price | High Price | Close Price | Previous Close |
|---|---|---|---|---|
| 58.50 |
| Top Posts |
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Posted at 16/10/2023 16:37 by jpuff Tiziana Life Sciences Announces Positive Six-Month Clinical Results in Multiple Sclerosis Patients Treated with Intranasal ForalumabOctober 16, 2023 at 7:00 AM EDTNumeric improvements were seen across key multiple sclerosis measures, including the Modified Fatigue Impact Scale, Expanded Disability Status Scale, Timed 25-Foot Walk test, Pyramidal Scores and NeuroQoL Fatigue scores.Data was presented at ECTRIMS (39th Congress of the European Committee for Treatment and Research of Multiple Sclerosis) on October 11, 2023NEW YORK, Oct. 16, 2023 (GLOBE NEWSWIRE) -- Tiziana Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced six-month data showing positive clinical improvements related to Modified Fatigue Impact Scale (MFIS) scores and similar important clinical measures of physical function in foralumab-treated, non-active Secondary Progressive Multiple Sclerosis (na-SPMS) patients participating in an Expanded Access (EA) Program. This follows on from previously announced positive six-month PET scan data which was presented at ECTRIMS 2023.The findings, which are summarized in table 1 below, show broad based six month improvements across various key measures for multiple sclerosis. Secondary progressive multiple sclerosis is hallmarked by an increase of disability over time. The table below shows a stabilization or an improvement in physical function of the various clinical measures over a six-month period.Table 1 EDSS Pyramidalscore T25FW MFISEA1 - ? - -EA2 ? - ? ?EA3 - - ? -EA4 ? - - ?EA5 - ? ? ?EA6 - - - ?- Denotes stabilization? Denotes improvement Fatigue, as measured above in MFIS, refers to an overwhelming sense of physical, mental, and emotional exhaustion that is disproportionate to the level of activity or effort exerted. It is a major, common, and often debilitating symptom experienced by many individuals with MS. It differs from the typical tiredness that everyone experiences from time to time. In the context of MS, it is called 'primary fatigue' and is a direct result of damage to the central nervous system. This kind of fatigue can significantly impact a person's daily life and functioning."I am pleased to see the continued clinical response to intranasal foralumab from patients enrolled in our expanded access na-SPMS program," stated Dr. Tanuja Chitnis, M.D., Principal Investigator and Professor of Neurology at Harvard Medical School (HMS) and senior neurologist at Brigham and Women's Hospital, a founding member of Mass General Brigham Healthcare System. "Notably, in this latest clinical update for patients EA 3 through EA 6, we have seen improvement in the Modified Fatigue Impact Scale scores in three out of four patients, which is significant since fatigue is a major complaint in this population. We have also seen various degrees of improvement in the Expanded Disability Status Scale, Timed 25-Foot Walk Test, pyramidal function scores and NeuroQoL Fatigue scores in a disease state that typically shows a decline in function over time. Howard L. Weiner, M.D., Chairman of Tiziana's Scientific Advisory Board and Co-Director of the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital noted, "With six patients now dosed in our na-SPMS Expanded Access Program and followed over a six-month period, we are seeing a highly encouraging efficacy signal in this difficult-to-treat patient population."Gabriele Cerrone, Chairman, acting CEO and founder of Tiziana Life Sciences noted "Intranasal foralumab is continuing to show clinical improvements over time in patients with na-SPMS where foralumab targets inflammation in the brain. Based on the totality of the clinical results seen to-date, I am hopeful that intranasal foralumab and its anti-inflammatory mechanism of action could provide relief to na-SPMS patients that currently have no available therapies."About ForalumabActivated T cells play an important role in the inflammatory process. Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor and dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets. This effect has been demonstrated in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects. The non-active SPMS intranasal foralumab Phase 2 trial is expected to start screening in November of 2023. Immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of neuroinflammatory and neurodegenerative human diseases.1,2About Tiziana Life SciencesTiziana Life Sciences is a clinical-stage biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana's innovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana's lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications.For further inquiries:Tiziana Life Sciences LtdPaul Spencer, Business Development and Investor Relations +44 (0) 207 495 2379email: info@tizianalifescie |
Posted at 17/5/2023 12:21 by jpuff Tiziana Life Sciences Announces Chief Medical Officer Invited to Give Presentation on Intranasal Foralumab on May 17May 17, 2023 at 7:00 AM EDTNEW YORK, May 17, 2023 (GLOBE NEWSWIRE) -- Tiziana Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced that its Chief Medical Officer is presenting at the Hanson Wade Novel Nasal Formulation and Delivery Summit on May 17 in San Diego."I was truly honored when Hanson Wade contacted me requesting that I speak at its Novel Nasal Formulation and Delivery Summit1," stated Matthew W. Davis, M.D., RPh, Chief Medical Officer of Tiziana. "I will be joined at the summit by several distinguished speakers from the industry and the FDA.2 The continued interest we receive on our intranasal foralumab program from pharma, investors and the media demonstrates that our novel approach to deliver the only fully human anti-CD3 monoclonal antibody intranasally has captured the attention of the medical community." |
Posted at 08/3/2023 14:49 by jpuff Tiziana Life SciencesPress ReleaseTiziana Life Sciences Announces Publication in Proceedings of the National Academy of Sciences (PNAS) Illustrating the Immunological Basis of the Mechanism of Action for Intranasal ForalumabMarch 8, 2023 at 7:00 AM ESTIllustrates that the immunological basis of the mechanism of action for intranasal foralumab is based on increasing production of naïve-like T cells and Tregs, while simultaneously decreasing the production of effector T cellsFurther, highlights how intranasal foralumab has similar immune gene expression effects in COVID patients, MS patients and in heathy volunteersConcludes that immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of inflammatory human diseasesNEW YORK, March 08, 2023 (GLOBE NEWSWIRE) -- Tiziana Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced a publication in the preeminent1 journal, Proceedings of the National Academy of Sciences (PNAS), that illustrates the immunological basis of the mechanism of action (MoA) for intranasal foralumab. A copy of the article can be found at pnas.org.2Howard L. Weiner, M.D., Co-Director of the Ann Romney Center for Neurologic Diseases at BWH and Chairman of Tiziana's Scientific Advisory Board, stated, "I am proud to be senior author on this important publication. The identification of a unique mechanism associated with nasal foralumab in humans was consistent across patients with COVID, multiple sclerosis and in healthy volunteers. This modulation of T cell inflammatory response that resulted from suppressing effector features in multiple T cell subsets is consistent with other research done at the Ann Romney Center and validates our scientific rationale for the upcoming IND filing to investigate intranasal foralumab in Alzheimer's."Dr. Tanuja Chitnis, M.D., Professor of Neurology at Brigham Women's Hospital (BWH) said, "It is an honor to be an author on this seminal research. Furthermore, the unique immunomodulatory signature of intranasal foralumab makes it a promising therapeutic candidate for several rare Orphan pediatric neuroinflammatory diseases, which currently remain untreated. It is my hope to study intranasal foralumab in these underserved indications.""This upcoming quarter will be an eventful and productive period for Tiziana," stated Matthew W. Davis, M.D., RPh, Chief Medical Officer of Tiziana. "The publication of foralumab's detailed mechanism of action dovetails with our forthcoming Alzheimer's IND filing for intranasal foralumab and the Phase 2 FDA review comments for our proposed MS trial, all of which are expected this month. March will also be the third month of intranasal foralumab administration in four Expanded Access (EA 3 through EA 6) patients followed by data updates in Q2 2023.Tiziana remains on track to begin its Phase 2 intranasal foralumab non-active Secondary Progressive Multiple Sclerosis trial in Q3 of this year.""I am thrilled that PNAS has chosen to publish this critical research on intranasal foralumab," commented Gabriele Cerrone, Executive Chairman and interim Chief Executive Officer of Tiziana. "Having an intranasal fully human monoclonal antibody that positively modulates the immune system allows Tiziana to explore multiple inflammatory disease indications in addition to multiple sclerosis (MS), and greatly increases the value of our groundbreaking research. The Company also notes Dr. Chitnis's exciting desire to study intranasal foralumab in rare Orphan pediatric diseases. Tiziana may pursue this unique and attractive opportunity when funding becomes available."About ForalumabActivated T cells play an important role in the inflammatory process. Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor, dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets, an effect demonstrated in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects. Intranasal foralumab Phase 2 trials are expected to start in Q3 2023 in patients with non-active SPMS. Immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of inflammatory human diseases.2About Tiziana Life SciencesTiziana Life Sciences is a clinical-stage biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana's innovative nasal, oral and inhalation approaches in development have the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana's lead candidate, intranasal foralumab, the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications.For further inquiries:Tiziana Life Sciences LtdPaul Spencer, Business Development and Investor Relations +44 (0) 207 495 2379info@tizianalife |
Posted at 11/6/2022 22:49 by jpuff Tiziana Life Sciences Announces An Interview on Clinical Improvements for 2nd SPMS PatientSource: GlobeNewswire Inc.Tiziana Life Sciences (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company enabling breakthrough immunotherapies via novel routes of drug administration, today announces an interview with Chief Executive Officer and Chief Scientific Officer Kunwar Shailubhai, PhD and Proactive Investors discussing the positive clinical results from the second patient with Secondary Progressive Multiple Sclerosis (SPMS) in the ongoing study as part of an expanded access program at the Brigham and Women's Hospital (BWH), Boston, MA.About Foralumab Foralumab (formerly NI-0401), the only entirely human anti-CD3 mAb, shows reduced release of cytokines after IV administration in healthy volunteers and in patients with Crohn's disease. In a humanized mouse model (NOD/SCID IL2?c-/-), it was shown that while targeting the T-cell receptor, orally administered foralumab modulates immune responses of the T-cells and enhances regulatory T-cells (Tregs), thereby providing therapeutic benefit in treating inflammatory and autoimmune diseases without the occurrence of potential adverse events usually associated with parenteral mAb therapy. Once a day treatment for 10 consecutive days with intranasal foralumab was not only well tolerated but it also produced strong clinical responses in COVID-19 patients. Based on these studies, the intranasal and oral administration of foralumab offers the potential to become a well-tolerated immunotherapy for autoimmune and inflammatory diseases by the induction of Tregs.About Tiziana Life SciencesTiziana Life Sciences is a clinical-stage biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana's innovative nasal, oral and inhalation approaches in development have the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana's two lead candidates, intranasal foralumab, the only fully human anti-CD3 mAb, and milciclib, a pan-CDK inhibitor, have both demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applications. |
Posted at 14/4/2022 16:03 by nerdofsteel LONDON and PHOENIX, April 14, 2022 (GLOBE NEWSWIRE) -- AccuStem Sciences, Inc. (OTCQB: ACUT), a life sciences company dedicated to improving outcomes for patients with cancer, is pleased to announce its uplisting from the OTC Pink Sheets to the OTCQB® Venture Marketplace (the “OTCQB”) |
Posted at 01/4/2022 16:08 by 1macosta Hi all. I need some advice and I hope this is the place to get some help. I have my TILS shares in Barclays stockbrokers and they are quite simply useless in giving me my share certificate. I spoke with a lady at Tiziana (contact details on the Tiziana website) and she told me Barclays are ignoring her requests and not replying. She said a few investors with tils in barclays are having the same problem. I have contacted Barclays and they say it's Tiziana who doesn't reply to their requests. Any advice would be much appreciated. Also if I eventually get my share certificate from Barclays, what will be the best broker to contact? Thank you in advance. |
Posted at 23/1/2022 18:08 by one_frankel Yes to take it private for pittance buddy and at the added expense of investors which is why GCs continuing to accumulate upon his position again...But unfortunately nothing this company states or does can be rightfully depended upon. |
Posted at 23/1/2022 17:21 by tricks08 GC is up to something Reb, we should find out what exactly within the next month or two.It’s been a painful news blackout for investors with the exception of that second MS patient joining the programme. A crumb of information in the grand scheme of things which didn’t even register with the market. |
Posted at 14/1/2022 09:23 by jpuff Be careful of shorters trying to panic investors into selling their shares at a low point just so they can profit themselves. |
Posted at 12/1/2022 16:43 by jpuff Very much smells of an orchestrated pump and dump this saga. It even seems to me that the company itself went along with it given their carefully timed press releases and huff and puff at the time. The whole mob probably got the signal to go short the shares just at the time innocent private investors were buying! An utter disgrace and a prime example of what's wrong with AIM and the U.K. stock market and capitalism at its worst. |
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