Syncona Share Discussion Threads

[alan@bj] 26/3/2018 17:09

Anyone aware of the reason for the fall today?

[luxaeterna1] 07/3/2018 15:35

Nightstar is an interesting company. Just consider the human, societal and financial benefit of preventing 100,000s of people going blind.

[rambutan2] 06/3/2018 17:43

And not forgetting yesterday's Nightstar latest:

Syncona Ltd, a leading healthcare company focused on investing in and building
global leaders in life science, today notes the announcement from its portfolio
company, Nightstar Therapeutics Plc (NASDAQ: NITE) (Nightstar).

Nightstar has initiated its STAR Phase 3 registrational trial ("the STAR
trial") to study the safety and efficacy of NSR-REP1 in patients with
choroideremia. The STAR trial is expected to enroll approximately 140 patients
across 18 clinical sites in the United States, Europe, Canada and South
America, of which six sites will be surgical centers.

Patients in the STAR trial are expected to be recruited primarily from the
ongoing Nightstar-sponsored natural history observational study (the NIGHT
study) in order to accelerate Phase 3 enrolment from this well-characterized
patient population. The primary endpoint of the STAR trial is the proportion of
patients with an improvement of at least 15 ETDRS letters from baseline in
visual acuity at 12 months post-treatment.[1] The primary endpoint will be
assessed at one-year by comparing patients in the high-dose treatment arm with
patients in the control arm.

Nightstar's STAR trial represents the first ever Phase 3 pivotal trial for
choroideremia, a rare disease leading to total blindness for which there is
currently no available treatment. In data from 32 patients treated with
NSR-REP1 across four open-label Phase 1/2 clinical trials, over 90 per cent of
treated patients maintained or improved their visual acuity over a one-year
follow-up period.

The full Nightstar announcement can be found here:

[rambutan2] 06/3/2018 17:42

Most recent fact sheet has us holding a fully diluted 38% at an £84m valuation, which suggests an awful lot of potential upside.

[ltinvestor] 06/3/2018 07:54

Today’s announcement regarding the potential Ipo of Autolus in the US is excellent news as the mkt caps of other companies in this space run into billions...

[vraic] 08/1/2018 18:03

Agree its a lock away , market cap now £ 1.4 billion ! £ 2.10.

[alan@bj] 07/1/2018 13:51

Midas verdict: Syncona was founded five years ago and has already achieved considerable success. It is likely to deliver further substantial growth, and the Wellcome Trust’s presence on the share register is reassuring. At 210½p, these shares are a long-term buy.

[ltinvestor] 07/1/2018 12:51

Midas (Mail) hot share for 2018 SYNCONA

[ltinvestor] 05/12/2017 08:30

This is one share that you buy and lock away.....LT

[audigger] 04/12/2017 16:55

A hint of a breakout....

[ltinvestor] 02/12/2017 16:16

Huge potential here over the next few years.75 Page research note by Numis.

[alan@bj] 20/11/2017 16:35

Interims due out on Wednesday?

[ltinvestor] 01/11/2017 08:24

Nightstar rising steadily on Nasdaq closing last night at $21.95

[audigger] 02/10/2017 09:38

I think the timing of my recent buy was a tad lucky as I had expected the share price to rise on the news relating to Nightstar rather than actual share price movement. Nice to see some exposure in the ST.

[ltinvestor] 01/10/2017 10:27

Write up and "buy" recommendation in today's Sunday Times

[rambutan2] 29/9/2017 09:07

The answer to this question appears to be very positive!

"The question now is how receptive public investors are to gene therapy biotechs. The companies in the sector to go public to date have delivered mixed returns, with the successes of bluebird bio and Spark offset by the steady decline of uniQure and implosion of Dimension Therapeutics."

[ltinvestor] 29/9/2017 08:30

The ipo was 5 times oversubscribed!!

[davidlloyd] 29/9/2017 08:10

Looks very well timed Golddigger!!
DL

[ltinvestor] 28/9/2017 21:17

Nightstar up around $10(70%) at the close!

[luxaeterna1] 28/9/2017 16:22

Nice opening

[audigger] 28/9/2017 11:59

Bought a few chunks of these yesterday for my kids ISAs. Some great potential here!

[ltinvestor] 26/9/2017 08:20

More good news today from Autulus.Potential here for another multi billion$ company in a few years time.....

[luxaeterna1] 19/9/2017 16:54

Am I right that the NASDAQ float is expected towards the middle of next week?

[elgordo] 16/9/2017 16:59

Update on Nightstar Nasdaq listing makes the headline in The Times Business Market Report today - "Syncona reaping rewards from feelgood factor". Describes Syncona as "one of the unsung heroes of British biotechnology", before going on to summarise the announcement.

[luxaeterna1] 06/9/2017 13:59

Syncona own a share of Autolus (a CAR-T immunotherapy cancer therapy), apparently Gilead have bid $12bn for a company with a similar treatment in the US. Now that should get some tongues wagging!

hxxp://citywire.co.uk/investment-trust-insider/news/syncona-shines-as-nightstar-heads-to-market/a1045996