Synairgen Share Discussion Threads

[bobaxe1] 28/8/2020 11:28

S9 just a motley short attack read for next news!https://twitter.com/Centre_Dean/status/1298902563660718080?s=09

[bobaxe1] 28/8/2020 11:22

Interesting post from yesterday..https://twitter.com/kupa85578441/status/1298926963344769025?s=09

[wetdream] 28/8/2020 10:41

Interesting that Fauci is now talking about screening ‘small molecules with specific anti-viral activities’ for early intervention.



9.52 onwards

[1gw] 28/8/2020 10:41

I read it as a further iteration of the Phase II trial, but with a pivotal after the pilot phase.

Shouldn't this have been rns'd?

[bignads] 28/8/2020 10:15

My initial response from the trial site update was "On no! They are going to delay approving SNG001 until next year.", the share price will tank.

However, now that I've thought about it more, it doesn't add up for the following reasons:

- the suggested phase III (pivotal) trial numbers are small (barely bigger than phase II) suggesting that this is not an issue of gaining greater statistical significance. We know we already have that for primary endpoints.

- If one was going to give conditional approval such as EUA, they would need to approve subject to a phase III trial. The numbers above suggest that this would be a formality - numbers do not need to be big because the case for approval is already very good.

- in the updated trial data, the comparison is a placebo not another drug such as remdesivir. This suggests that the precondition of better results than an extant treatment is not a pre-requisite. This also suggests the data for SNG001 is already very good (and the alternatives certainly no better).

All in all, I think we're in a very good place.