Summit Therapeutics Share Discussion Threads

[barrieb] 13/2/2018 16:09

Nice stateside!! something brewing?

[hugus maximus] 13/2/2018 15:23

Interesting note Solomon. Indeed this is such a complex issue. Just in on Seeking Alpha ... attempting to correlate the relevance of data in drug research must be a minefield:

"Another recent scare happened at the beginning of 2018 that involved a couple of deaths reported on the FDA's adverse event database in regards to Exondys 51, which were determined to be the result of DMD disease progression and not Exondys 51. Events like this latest "news" report, which wasn't even relevant enough to be actual news, serve to shake out weak hands in Sarepta, making room for more steady minds, who can deal with the ups and downs of trying to treat a disease as horrible as DMD is."

[solomon] 13/2/2018 13:56

That's a good upside percentage, Hugus. I still think that the share price suffers from the 'could it be a Benecol' effect. Benecol reduces cholesterol (the bad variety anyway) but has not yet been shown to reduce cardiovascular disease. I say this very quietly. And I will only say it once.

[hugus maximus] 13/2/2018 13:47

"Summit Therapeutics (NASDAQ:SMMT) initiated with Buy rating and $33 (206% upside) price target at BTIG Research."

[hugus maximus] 13/2/2018 11:05

Let's hope that some clarity in the detail re: 24 wk data turns sentiment around before the 48 wk results become another "will they ... won't they?"!

[waterloo01] 13/2/2018 08:49

A big IF re accelerated approvals. Suspect the share price is a mix of US market meltdowns and the questions raised by the 24wk data. Hopefully they will release some more granular data that will back up the functional effects over the next weeks/months.

[hugus maximus] 13/2/2018 08:45

"Hercules"? The idea of data sharing must be difficult given the diverse approaches involved. Glyn's comment about accelerated approval must be something that's considered in the various rounds of current discussions.

Apologies for stating the obvious but I'm baffled by the share price (aside from current market downturn), given that the 24 wk data holds so much promise, are we suffering from some sort of American chauvinism?

[waterloo01] 12/2/2018 19:18

Not sure I registered 'Hurcules'?



“We are very excited,” says Glyn Edwards, chief executive of Summit. “If the final results are absolutely spectacular there’s a small chance it could be approved within months. But otherwise we would have to do a bigger phase three trial, which would take another couple of years.”

Could this collaborative approach work in other areas of medicine?

[hugus maximus] 12/2/2018 14:24

Age football? Apologies ... assumed you'd made it up. ;-/

Indeed ... "oh for some spare cash". (Not the title of an Ian Drury song!)

[football] 12/2/2018 12:10

We are all Einstein's with Google Hugus or at least Magnus Magnusson ;)

Still can't get over how good the baseline/rhythm section is on "hit me with your rhythm stick" oh well showing our age again

As for the share price just wish I had some spare cash but hands are tied at present

[hugus maximus] 12/2/2018 11:57

Football! Memory or google?

'Cheap as chips' ... also make a good reason Chris.

[chrisatrdg] 12/2/2018 09:32

'Cheap as chips'
Have we reached the bottom now at current share price I believe the shares are as 'cheap as chips' & at pre - news levels.Time to top up?

Edit: Made a small top up of 435 shares to round up to 41,000 shares just to test my theory (all that I could afford).

[football] 12/2/2018 08:50

Summer, Buddy Holly, the working folly
Good golly Miss Molly and boats

Hammersmith Palais, the Bolshoi Ballet
Jump back in the alley and nanny goats

18 wheeler Scammels, dominica camels
All other mammals plus equal votes

Seeing Piccadilly, Fanny sniffin' Willie
Being rather silly and porridge oats

[hugus maximus] 12/2/2018 08:45

Are we at the bottom? Australia and Far East still reacting negatively but FTSE up over 1% here.

"Reasons to be cheerful ... 1-2-3?" Anyone?

[hugus maximus] 09/2/2018 14:21

filmster .... well done, I should have sold some but was waiting for a NASDAQ share price hike that didn't materialise. Share price drop has deepened over past few days as the dollar / pound rate moved against us .... uk shares are dollar led ... aside from overall 4% drop in Biotech this week as a result of general share drift. There is nothing to suggest any negative news about the progress of either DMD P2 or C Diff at Summit.

[filmster] 09/2/2018 13:08

Anyone know why the share price drop apart from the markets being down? I luckily sold out on news now looking to buy back in again. Just wondering if there's any reason i shouldn't after such good news

[hugus maximus] 09/2/2018 08:44

Scuppered on many levels ... strengthening pound now @ $1.40 and the market's reaction to potential interest rate hike, ensures a ride worthy of the Winter Olympics.

[hugus maximus] 08/2/2018 09:44

Interesting note Waterloo ... there is a huge anticipation from general public that 'Gene Therapy' is going to come through with a fix for many problems, in the closely foreseeable future.

I'm old enough to remember there was a similar anticipation in the late 60's / early 70's, that science would have cancer cured in 10 or 15 years.

The notion of Gene Therapy is an amazing one but it's often presented as if simply knowing where the switches are, we can quickly work out how to turn them on and off. There is still much work going on in the way (in layman language)a virus is designed to deliver the switch. Whereas for example the toxicity issues discussed here current methods re AAV are hugely problematic ... most specifically in the levels required for "muscle disorders".

[waterloo01] 08/2/2018 07:21

One reason, gene therapy might not be quite so quick off the mark.

Nothing new in the webinar (as expected as no RNS prior). Basically need to wait on 48wk data although they did again mention the idea of going for a new biomarker in developmental myosin.

[hugus maximus] 07/2/2018 17:01

Anyone picking up the webinar? I have nothing on my access page? Using recent Safari on a 2017 Mac Book Pro OSX Sierra ... nothing on the page with plugin installed. "Number 9 .... number 9 ... come in Number 9 ....?

[hugus maximus] 07/2/2018 15:57

This CRISPR work may one day fix all sorts of genetic disorders but for the DMD families, it's sadly still quite some time off. If EZD follows the success of 24 wk data onto 48 wk P2 trial results, it will most likely still find several years of demand.