Share Name Share Symbol Market Type Share ISIN Share Description
Scientific D. LSE:SDI London Ordinary Share GB00B3FBWW43 ORD 1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  +0.00p +0.00% 31.50p 30.00p 33.00p 31.50p 31.50p 31.50p 134,114 08:00:00
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Electronic & Electrical Equipment 10.7 0.9 0.0 - 27.98

Scientific Digital Imaging Share Discussion Threads

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SCSW is out tomorrow - hopefully there'll be some coverage of the interims, which missed the cut for the last issue.
....... Top Trends in Biopharmaceutical Manufacturing, 2017 .............. THE Biopharmaceutical AREA is where some parts of the SDI Group are actively engaged It is an area of growth of around CAGR 14.5% hTTp:// One of SDI Divisions are involved in this ''Applied Thermal Control ATC, acquired in August 2017, is redesigning one of its chiller systems to comply with new EU regulations prohibiting the sale of equipment containing fluorinated greenhouse gas from 2022. These new chillers will work in bioprocessing systems and will be tested for use by one of the world's largest suppliers of bioprocess automation'' Another division is also ''Sentek Sentek increased sales turnover by 23% in the period, driven by continuing strong sales growth of its single-use electrodes. These electrodes are used in bioprocessing and process analytics applications and Sentek is an OEM supplier to two major life science and healthcare companies. Since sales of the systems made by these companies are increasing globally to pharmaceuticals and biotech customers, sales of the electrodes continue to grow in line. Sentek has also seen growth in demand for its ion selective electrodes as a major UK competitor has ceased trading leaving Sentek as the only UK manufacturer of this type of electrode. To ensure the brand maintains quality and meets production demands, Sentek has leased an additional building to double the size of its manufacturing facility and has recruited additional production staff.'' An area which seems to be one to yield decent returns ''Downstream processing remains the major bioprocessing bottleneck Downstream purification including chromatography continues to be the area cited as requiring the most technological improvements.'' Like I posted a while back , different divisions are now starting to compliment each other rather nicely , so it seems we have a plan which is coming together in an exciting growth area hTTps:// ''Global industrial bioprocessing market has been witnessing strong growth over the past few years on account of increasing demand for bio-based products. Industrial bioprocessing includes manufacturing of food, pharmaceuticals, nutraceuticals, chemicals and polymers. '' Biopharmaceuticals could become the core of the pharmaceutical industry, but not without significant transformation in the laboratory and in strategy, technology, and operations. hTTps:// ''Today, biopharmaceuticals generate global revenues of $163 billion, making up about 20 percent of the pharma market. It’s by far the fastest-growing part of the industry: biopharma’s current annual growth rate of more than 8 percent is double that of conventional pharma, and growth is expected to continue at that rate for the foreseeable future.'' I WONDER if SDI next acquisition is also involved in this area ? The global top 10 bioprocess technology market is expected to reach USD 71.03 Billion by 2021 from USD 39.30 Billion in 2016, at a CAGR of 12.4% from 2016 to 2021. Rapid growth in pharmaceutical and biotechnology industries, growth in the number of new drug launches, strong trend of R&D in life sciences research, increasing government support for pharmaceutical and biotechnology industries, and rising prevalence of chronic diseases are the key factors driving the growth of this market. hTTps://
Something new ... a new market is emerging , one IMO that will rock the Pharmaceutical Industry to its foundations and turn many olde named diseases on their heads as they get recognized as prion diseases, with various genotype mutations. Prion Disease Diagnostics Market – High Cost of Therapies & Forecast 2017-2025 The global market for prion disease diagnostics will likely expand at a moderate pace in the near future on the back of technological progress in the domain of medical diagnostics and rising demand for sophisticated equipment for the diagnosis of fatal and rare ailments. At present, however, there are no medications available that could offer complete cure to patients suffering from the prion disease. With rising number of deaths caused by the malady, the demand for precise diagnostics for prion disease is expected to rise significantly in the near future. The global market for prion disease diagnostics is expected to be fortified by the recent progress in medical imaging and by the gigantic strides witnessed in the diagnostic industry. Despite such tailwinds, the market is witnessing lackluster growth on account of the dearth of awareness about this rare condition and the high cost of existing therapies and diagnosis technologies. Remember ProReveal detects Prion protein residue on surgical instruments after cleaning process has been carried out ie to see if any prion protein residue is still present Prions are infectious agents composed entirely of a protein material that can fold in multiple, structurally abstract ways, at least one of which is transmissible to other prion proteins, leading to disease in a manner that is epidemiologically comparable to the spread of viral infection.
The new Syngene website is a vast improvement worth checking out.Http://
Take a look hTTps:// ''However, the latest case, in 2016, is the first instance of probable and/or definite clinical vCJD in a 129MV individual, raising concerns that a second wave of vCJD may occur in individuals of this genotype [1].'' ''Retrospective appendix studies have indicated that 1 in 2,000 individuals have evidence of abnormal PrP in the appendix.'' ''One interpretation is that the period of human exposure to BSE was more extended than previously thought. These considerations are important for public health because individuals subclinically infected with vCJD may have the potential to transmit disease to others'' '' It is, however, unknown whether this test can detect prions in the blood or plasma of individuals with other codon 129 genotypes'' IMO there are many other MV genotype at PRNP codon 129 existing for which no testing has been done Hence there are many other forms of vCJD about which we know nothing, other than they can lie dormant for decades. The latest case is DIFFERENT '' It remains uncertain whether this case marks the start of a second wave of variant Creutzfeldt–Jakob disease in persons with the MV genotype at PRNP codon 129 (the most common genotype in the United Kingdom), mirroring the long incubation periods seen in persons with the MV genotype who have other acquired prion diseases, notably kuru.1 This case emphasizes the importance of performing an autopsy and molecular strain typing in cases of prion disease to ascertain the prevalence of human prion disease related to bovine spongiform encephalopathy. MV genotype at PRNP codon 129 is THE MOST COMMON , TWICE as common as the PrP data giving 1 in 2000 published True carrier numbers of various forms of vCJD will be less than 1 in 666 people ''The genotype at codon 129 can be methionine homozygous (MM), valine homozygous (VV), or heterozygous (MV), and in the UK population, the normal codon 129 distribution has been reported as 39% MM, 50% MV, and 11% VV 8. Two biochemically distinct forms of PrP Sc, type 1 and type 2, can be deposited in the brain.'' hTTps:// codon 129 MV genotype is MORE common than MM type which the 1 in 2000 is based upon
PJ1 have you sold out ? Housing market in the UK is now dropping like a brick ... as I said it would over 1 year back Re carriers of CJD and vCJD in the UK , where present guidance is 1 in 2000 This is now in error New data has come out which I will include in a post son which shows there is a new type of CJD variant which was NOT tested for when they did the last checks on cut out appendix from people years back This is now thought to be twice as common New data will show carriers of both types are in fact 1 in 666 people , which is around 3 times as bad as when NICE issued this hTTps:// ''1.3 A separate pool of new neuroendoscopes and reusable surgical instruments for high-risk procedures should be used for children born since 1 January 1997 (who are unlikely to have been exposed to BSE in the food chain or CJD through a blood transfusion) and who have not previously undergone high-risk procedures. These instruments and neuroendoscopes should not be used for patients born before 1 January 1997 or those who underwent high-risk procedures before the implementation of this guidance. '' There now exists TWO sets of surgical instruments in the NHS 1 set for people born after 1997 Another set for people born before 1997 ( ie higher risk CJD ,vCJD carriers ) , folks now aged 21 or older
buywell3-are you in too deep here...??
pj 1
News just in from USA , CWD is spreading Feb 28, 7:46 PM hTTp:// ''New research on CWD also has led the Centers for Disease Control and Prevention to issue new advice on potential human impacts of CWD. On its website, the CDC now warns, "To date, there have been no reported cases of CWD infection in people. However, animal studies suggest CWD poses a risk to some types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain." But it isn't, hunters are still eating the deer and Elk they shoot And have been for years The first USA human cases has IMO already happened many times but has not yet been correctly diagnosed as such Further weakness in USA now looking likely Anyone fancy a venison stateside sausage ? News just in from USA , CWD is spreading Feb 28, 7:46 PM hTTp:// ''New research on CWD also has led the Centers for Disease Control and Prevention to issue new advice on potential human impacts of CWD. On its website, the CDC now warns, "To date, there have been no reported cases of CWD infection in people. However, animal studies suggest CWD poses a risk to some types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain." But it isn't, hunters are still eating the deer and Elk they shoot And have been for years The first USA human cases has IMO already happened many times but has not yet been correctly diagnosed as such Dept. of Health warns against eating deer meat in counties affected ... Mississippi News Now-Feb 13, 2018 Follow guidelines to avoid the spread of Chronic Wasting Disease Picayune Item-Feb 14, 2018 Department of Natural Resources official warns that chronic waste ... In-Depth-Minneapolis Star Tribune-Feb 13, 2018
I note that Matthew Peskett of Proreveal's distributor Peskett Solutions has "liked" this article which suggests that protein deposits in the brain might have been transmitted by contaminated neurosurgical instruments: Http:// "Amyloid Protein Transmission Through Neurosurgery Published: February 15, 2018. Released by University College London Amyloid beta pathology - protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study. For the paper, published today in Acta Neuropathologica, researchers studied the medical records of four people who had brain bleeds caused by amyloid beta build-up in the blood vessels of the brain. They found that all four people had undergone neurosurgery two or three decades earlier as children or teenagers, raising the possibility that amyloid beta deposition may be transmissible through neurosurgical instruments in a similar way to prion proteins which are implicated in prion dementias such as Creutzfeldt-Jakob disease. etc"
When that profit number in the 'fundamental data' section of the data reads over £2M instead of £0.9M ... new investors will start to notice SDI It won't be very long now till that number comes
The Buy and Build makes sense to me , and the numbers prove it , plus the market agrees and the share price chart is now looking very good. We know that we can expect good numbers coming again and turnover and profits up higher once more. We also know another acquisition is planned for later in 2018 No doubt soon after results With the recent small but pertinent USA acquisition that gives ATIK some extra clients and product range , 2018 forwards earnings look like being positive yet again. SDI BOD have found a formula that works Cash is now being thrown off as profits rise Within 12 months SDI can afford to buy smaller companies for £1M to £2M from existing cash but have in place an agreed loan deal with a bank which will enable to go higher to around £4 to £5M if an acquisition of that size is too good to miss. Also I detect some rationale coming through with how some of the acquired companies are starting to compliment each other re both products manufactured and with clients that are likely to buy from the ever widening SDI range Growth of over 10% per year plus ... looks assured following the proved formula Do the maths re earnings and profits ( see my post a few weeks back ) I think SDI can hit £1 in Five years dyor
I had an email (rec) but it's premium now with Champion so you have to pay for the complete article. It was a good site but so many people charge I look for other recs.
Has anyone read the above article? I assume it's reasonably positive given the progress and potential here, but I'm not a premium subscriber myself: Https://
Scientific Digital Imaging – lots of ‘Buying’ but does it all make sense? New research note covers its ‘Buy and Build’ strategy and considers the potential appeal for investors.
For a small company SDI turn out some very impressive/cutting edge products I assume this latest one and the others that have gone before are made to satisfy the clients wishes Natural evolution of 'best selling lines' should ensure that turnover keeps rising Staying ahead of the game/opposition is necessary I look forwards to more orders soon to be placed for ProReveal by the NHS as the July 2018 implementation date imposed by the DoH looms ever closer
We are at a very important moment in the history of medical understanding Are amyloid beta and tau proteins prions ? I think they are which means a whole can of worms get opened that have been hidden since 1997 Alzheimer's Disease and Prion Protein Alzheimer's disease (AD) is a devastating neurodegenerative disease with progressive loss of memory and cognitive function, pathologically hallmarked by aggregates of the amyloid-beta (Aβ) peptide and hyperphosphorylated tau in the brain. Aggregation of Aβ under the form of amyloid fibrils has long been considered central to the pathogenesis of AD. However, recent evidence has indicated that soluble Aβ oligomers, rather than insoluble fibrils, are the main neurotoxic species in AD. The cellular prion protein (PrPC) has newly been identified as a cell surface receptor for Aβ oligomers. PrPC is a cell surface glycoprotein that plays a key role in the propagation of prions, proteinaceous infectious agents that replicate by imposing their abnormal conformation to PrPC molecules. In AD, PrPC acts to transduce the neurotoxic signals arising from Aβ oligomers, leading to synaptic failure and cognitive impairment. Interestingly, accumulating evidence has also shown that aggregated Aβ or tau possesses prion-like activity, a property that would allow them to spread throughout the brain. In this article, we review recent findings regarding the function of PrPC and its role in AD, and discuss potential therapeutic implications of PrPC-based approaches in the treatment of AD.Is
Well I’ve taken advantage of the EIS 3 yr anniversary stock & bought back in today, I should never have sold but I’m grateful to be able to change my mind at a v reasonable cost considering how well the results read. There appears a seller in the 27.7-28 area who I’ve not yet cleared if anyone wants to top up it’s an opportunity to get reasonable size done, my buys are delayed trades btw Thanks for all the excellent commentary here👍
Re latest SDI acquisition of the USA company QSI I like the ATIK website it seems very user friendly QSI is now part of the same group as Atik By STEVE CHAMBERS ON FEBRUARY 2ND, 2018 I am very pleased to report that the purchase of the QSI brand completed on Thursday 1st of February. At Atik, we have a sincere respect and admiration for the QSI camera designs and the people behind them. After the incredibly sad news that the QSI joint founder Neal Barry passed away in 2017, QSI’s board of directors decided to restructure the company. QSI have long been both a market leader in Astro-imaging, and an important part of the astronomical community. By purchasing QSI, we can provide a bright future for this much-loved brand. This is obviously still very early days, but the plan is to continue the production of the QSI cameras and, looking further ahead, develop new models in the range. We feel QSI addresses the market for extremely high quality cameras made without compromise. Indeed, over the last few weeks while learning the details of the camera designs, I fully came to understand that nothing has been spared in the pursuit of that quality. In the past, when astronomers have wanted the best cameras, they have gone to QSI. We are committed to taking on these values and continuing the production of these cameras to the standard expected of QSI. QSI isn’t just about the cameras, but also the owners and employees whose drive and vision over the last 12 years has been inspirational. I would like to say a heartfelt thank you to Mike and Irene Barry, Dave Challis and Kevin Nelson. These people have gone far beyond our expectations to enable a smooth transfer of knowledge. It’s been a real pleasure to work with them. We have plans to restart manufacture in March/April, initially, by utilising unused space in the existing Atik production facility in which to install the required assembly equipment. Please bear with us while we work through the fine details including recruiting and training new staff to continue the procedures specific to QSI. We have been very grateful for the goodwill received from the QSI community and we look forward to a long and bright future for QSI. hTTps:// Sounds like SDI did good
buywell3 - Had not noticed you had posted above on the GSK thread - have just referenced your post there to this thread - Might generate more interest here -
The first case of CWD in humans is likely to come from the USA from eating prion contaminated deer or elk, however it could be from Norway or South Korea where the problem is also located. When it does ... and IMO this is likely within 1 to 2 years from now as things are now moving fast , and CWD testing of shot deer and elk is gaining traction as CWD spreads. hTTp:// The USA is going to have to test their surgical instruments for prion protein residue like the NHS is going to do by this July. RE vCJD and CJD which were caught by UK people eating Prion infected beef , BSE it was termed in cattle. Well now in the USA they have a prion infected problem with deer and Elk , they call it CWD over there ... it is also springing up in other countries too. It is going to be a big problem worldwide when those in the know admit that Prions are causing many brain disorders in humans Diseases that have been named many other names 50 to 100 years previously will get renamed as Prion diseases , with genetic mutations causing the various distorted shapes of prion proteins in the human brain Research: CWD may pose risk to humans FEB 4, 2018 Chronic wasting disease, a fatal brain illness killing area deer, may have the potential to infect humans, according to warnings from North American governments. And while there has not been a case of a human infection, local experts said they have been monitoring the illness with the same concerns. “We’re absolutely discussing things like that,” said Wayne Laroche, the Pennsylvania Game Commission’s special assistant for chronic wasting disease response. Last year, a branch of Health Canada — the Bureau of Microbial Hazards — issued a risk advisory opinion, warning that “the most prudent approach is to consider that CWD has the potential to infect humans.” That warning followed a series of tests performed by Canadian researchers on animals, including human-like macaque monkeys, which became infected with the disease. Officials at the U.S. Centers for Disease Control and Prevention also have referenced the tests, explaining macaques contracted the disease when they were fed muscle or brain tissue from infected deer and elk. Some of that meat, according to the CDC, came from asymptomatic deer — deer infected with chronic wasting disease that appear healthy and have not yet begun to show symptoms. “To date, there have been no cases of (chronic wasting disease) in people and no direct proof that people can get (the disease),” according to a CDC report. “Nevertheless, these experimental studies raise the concern that (the disease) may pose a risk to people and suggest that it is important to prevent human exposures to (it).” Chronic wasting disease is a resilient prion — an infectious protein — which attacks deer brains, eventually leading to a loss of motor functions and death. It is similar to but not the same as mad cow disease. In some cases, a deer doesn’t begin to show symptoms of chronic wasting disease until a year after contraction, according to the Game Commission. Symptoms include drastic weight loss, stumbling, listlessness and other neurologic symptoms. The disease was first detected in Blair and Bedford counties after the 2012 hunting season. A disease management area spanning more than 2,000 square miles has since been created, and it includes parts of Bedford, Blair, Cambria, Clearfield, Franklin, Fulton, Huntingdon and Somerset counties. The area is known as DMA 2. The disease likely got its start sometime in the 1960s at a feed testing facility in Colorado and was transported to other areas through infected deer. “They were trading deer,” Laroche said, hinting at a larger problem of humans spreading negative environmental factors from place to place. “It all boils down to people,” he said. “We’re moving everything around.” Chronic wasting disease has been detected outside of North America, including in Norway and South Korea. Locally, 25 deer tested positive for chronic wasting disease in 2016, Laroche said. All of the deer were in or near DMA 2, “the only area of the state where (the disease) has been detected in the wild,” according to Game Commission data. In 2017, 55 deer tested positive for the disease in Pennsylvania, Laroche said, revealing that the number could increase as 4,000-plus 2017 samples still have not been tested. Chronic wasting disease can be spread through direct physical contact or through bodily fluids, meaning if a deer expels excrement onto a surface and another deer comes in contact with that surface, it can become infected. That makes areas frequently populated by deer — bait piles, salt licks and deer pens — especially concerning, Laroche said. “Those are likely places where we might have a high enough dose for infection,” he said. And once an area is contaminated, it can remain that way for more than a decade, Laroche said. “This stuff can be on the landscape for at least 15 years and be infectious,” he said. To both study and eliminate the spread of chronic wasting disease in Pennsylvania, Game Commission officials have occasionally suggested culling deer. In early 2017, officials addressed a crowd gathered at Central High School, revealing a consideration of using sharpshooters to kill targeted groups of deer in areas where the disease is abundant. And just last month, officials announced a since-halted plan to kill about 40 deer in the Portage area to monitor the spread of chronic wasting disease. In both of those cases, plans to eliminate deer were met with much criticism from local hunters who are concerned the killings could drastically decrease the chances of bagging a buck during the following hunting seasons. “Of course everybody is worried about the deer (they’re) going to get next year,” Laroche said. Laroche said he has spoken with a number of hunters who believe the problem will go away or “burn itself out” without human intervention. “It may burn itself out, but there may be just smoke and ashes left,” Laroche said, explaining the disease has already decimated deer populations in Wyoming, where it is predicted that the animals “could be extinct in 40 to 50 years” if remedial action is not taken. “We absolutely need the support of the public,” Laroche said. “We are doing it for them, for their kids and for the future of hunting.” One thing is for sure: Now that chronic wasting disease is here, Pennsylvania hunting is going to change, said John Kasun — a longtime hunter, outdoors writer and columnist for the Mirror. “I don’t want to take a doomsday approach, but we are going to see a change,” he said. Kasun said he encourages hunters to strive to be part of the solution through engaging with officials, listening and responding with thoughtful feedback. He also said they should report any suspicious deer activity. Kasun also acknowledged a culture of conflicting information and opinions surrounding chronic wasting disease, calling the illness “a cauldron of misunderstanding and misinformation.” “I think we have to increase our communications about the issue,” he said. “We should be focusing on what we can do to help. … Unfortunately nobody has that answer yet.” At least one Blair County deer meat processor, who asked not to be named, made sure to point out that there is no evidence that humans can surely contract the disease and said he is doubtful that they can. It seems it will be some time before that question can be answered, as “scientists expect the study to take many years before they will determine what the risk, if any, of CWD is to people,” according to the CDC. To date CWD infected animals exist in 24 states of the USA The spread to states is increasing hTTp://
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