N4 Pharma Share Discussion Threads

[parob] 04/3/2018 17:54

From Nick2412's post from Thursday:On sildenafil & Nuvec and the ongoing differentiation work. NT reply re Nuvec:- "we will update on latest results and plans shortly, all currently on plan for q2 results on sildenafil."Will be interesting to see if the latest results and plans for Nuvec will appear in the same RNS or two separate RNS.

[hughwilson] 04/3/2018 14:01

I am very positive about N4. That is my honest opinion and not a ramp. I stand by what I say and am willing to discuss any concerns.

[jpuff] 02/3/2018 21:29

Beaufort allegedly up to their necks in it.. hTTps://www.justice.gov/usao-edny/pr/six-individuals-and-four-corporate-defendants-indicted-50-million-international extract.. In furtherance of the scheme, the Beaufort Defendants opened brokerage accounts for their clients in the names of off-shore shell companies with nominee shareholders and directors, and then conducted manipulative trading of stocks of U.S. publicly traded companies listed on U.S. over-the-counter exchanges. Beaufort Securities facilitated at least ten “pump and dumpâ€? schemes involving U.S. publicly traded stocks, generating over $50 million in proceeds for its clients. Notably, Beaufort Securities had affirmed to the Financial Conduct Authority (“FCAâ€?) in the United Kingdom in July 2016 that it had taken remedial measures to correct deficiencies in the firm’s financial crime controls and anti-money laundering processes. Additionally, between January 2011 and February 2018, the Beaufort Defendants; Loyal Bank; Loyal Agency; Baron, the Chief Business Officer of Loyal Bank and a Director of Loyal Agency; and Bullock, the Chief Executive Officer of Loyal Bank and a Director of Loyal Agency, together with their co-conspirators, devised and engaged in a scheme to launder securities fraud proceeds for their clients.

[ch1rp] 02/3/2018 12:19

They must have read our minds:)))

[parob] 02/3/2018 12:11

Space Robot? @Space_Robot1Can I assume it's going to take a long time for any Beaufort clients to place trades? So it could see a bit of a squeeze in certain shares as no Beaufort client can sell?AIM Chaos? @AIM_ChaosReplying to @Space_Robot1Yes, think this could be the case. Perversely, it could actually bode well for #N4P, if a gamechanger RNS were to land.Space Robot? @Space_Robot1Replying to @AIM_ChaosYes that's my thoughts too, and we're very much due some news. I wonder what the situation is now with the warrants?AIM Chaos? @AIM_ChaosRe the warrants - they'll be locked in also I believe. Which could potentially also be a benefit for N4 as the warrant churning will be put on hold.

[ch1rp] 02/3/2018 11:45

Nigel runs a tight lipped ship. You will know when the time is right:)))

[jimmmy] 02/3/2018 10:57

Anyone any ideas on how their trip to Japan went, thought we might of had some sort of feedback

[ch1rp] 02/3/2018 09:27

Courtesy of Chartist lseToday 09:21Next bull signal as soon as 30.40 and 30.95p are climbed. Then rise to 35-37p and finally 52p.(Nice to see blue on a global red day.)

[urigem] 02/3/2018 08:39

a midday friday snowy rns would be nice

[qs99] 02/3/2018 08:17

nice opening

[urigem] 02/3/2018 08:12

MORNING ALL

All would be good to be back over 30 for the weeks close, which does not seen an issue, as lows volume moves up/or down should be mostly ignored, however it does show a how patient buying /selling can benefit on AIM you really only ever want to trade when conditions suit - on this size cap could cost/make you 20% without much effort at all.

[parob] 02/3/2018 08:04

Would be good to see us back over 30p today.

[waterloo01] 02/3/2018 07:53

Note Beaufort has been put into admin.

[hughwilson] 01/3/2018 21:58

Nick2412,
What the latest Nuvec results will hopefully demonstrate is that it is effective when used across a broad range of the most common cell structures. If successful then the significance of that will be that it will become the natural successor to the current Lipid system making it the new industry standard.
If that were to be the case then the effect on N4`s share price would be hard to imagine at the present time but would be very substantial.

[nick2412] 01/3/2018 21:14

Yes, Parob, I'm assuming an update on the points of difference work and, who knows, perhaps a general update from the Japan visit. Inital results suggest Nuvec is a proverbial no-brainer given the impressive results so far and the 90% 'falling off' from the existing lipid approach and the resultant unwanted immunotherapy effect.

Early days but if the early results for Nuvec are reinforced with more data then it might make sense for a large pharma to buy the product outright rather than spend on numerous milestones and ultimately, if their clinical development products are successful, royalties.

[parob] 01/3/2018 20:59

That's great Nick, thanks for sharing NT's responses. So an update on latest Nuvec results (I assume point of difference) and plans soon.Fits in with Myles' last N4P tweet:AIM Chaos@AIM_ChaosHi Hugh - yes I think we'll be getting an update on Nuvec in the very near term. Ideally it'll cover strategy going forward for development, promotion and monetisation. AIM Chaos@AIM_ChaosI've held off on my own update as want to hear definitively what's going on with Nuvec and Sildenafil trials. Expecting comprehensive, separate updates on both. Needless to say, current fair value should be way above my current FV of 63p.

[nick2412] 01/3/2018 20:43

Just a reminder from the November '17 Share Soc presentation of the CEO's comments specifically on Nuvec. :-


Have had “ fantastic results”

Non in-vito toxicity (tested in animals & humans), no unwanted inflammatoru responses, provides high DNA loading capacity, protection of DNA from enzymes, delivery of large nucleic acids in-vivo studies. : not so for any of that list current lipid / nanoparticle system

Pharmas are currently using lipid / nanoparticles but “many problems”

Nuvec :- Uniquely designed to work with the shape & structure of DNA / RNA : not so for current lipid / nanoparticle system

Nuvec :- Can get a lot more DNA / RNA loaded. A really high level of DNA loaded and bound on its way to the cell. An incredibly high amount.

Nuvec :- “Don't get much falling off with around 95% reaching it's target - with lipid / nanoparticle system as little as 10% can reach the target.

Falling off with lipid / nanoparticle system ends up with unwanted Immunotherapy effect.

“You want the DNA to do its thing in the cell you don't want it floating around the rest of the body ending up in the wrong place.”

“clever design”

“Not difficult to make. Not a hugely expensive manufacturing process. Very,very well placed when we start taking it to market”

“Can probably deliver 4 or 5 DNA / RNA strings at the same time. Another key benefit in the delivery.”

“Reason we are so excited – massive opportunity. Market set to increase. DNA drug delivery and nanottechnology market is forecast to increase to about $12 billion by 2023.”

“Deals in this space are massive.”

Examples “Crescendo Biologics 2016 multi target application using special antibodies for cancer – they got $36m up front payment, further milestones and royalties up to $754m”

“There are a huge amount of bio /pharma companies in this space looking for solutions.”

“If you are spending 200m to 300m to take a DNA vaccine through to market why would you not spend £20m to £30m on a system that is going to give you greater potential to get there?”

“ At the bio forums about one third of the market are looking at cancer vaccines and therapies.” Nuvec:- “wider potential than just cancer vaccines :- e.g. cancer therapeutics. Immunotherapy, reduction in antibiotic resistance etc.

N4 Pharma – not taking any drug through to market and spending 200m to 300m but providing the pharmas / biotechs who are doing this with the system to assist them. Early potentially lucrative deals and no cost outlay for drug development. N4P will still get milestones as a drug is developed and royalties if it eventually reaches market.

[nick2412] 01/3/2018 20:29

Yes take it into private messaging guys. Hugh adds real value with his on-topic informative posts but, with respect, taking the bait from those who are blatantly trying to wind-up is exactly what they want. Just ignore him Hugh or put him on filter.

Back on topic :-

As others have posted we should get further news on Nuvec soon. Nigel T kindly answered a couple of queries to me.

I asked if there would be another presentation as the November one was excellent and highly informative. NT reply :- " will definitely do an update presentation when we can."

On sildenafil & Nuvec and the ongoing differentiation work. NT reply re Nuvec:- "we will update on latest results and plans shortly, all currently on plan for q2 results on sildenafil."

I understand Myles McNulty (Aim Chaos) is awaiting this update before revising his detailed note where he hasn't, as yet, included a valuation for Nuvec. He'll revise after the anticipated update. Currently his conservative valuation for the four reformulation products is 63p.

[jimbobaroony] 01/3/2018 18:32

You are free to post as you wish obviously.

[flashheart] 01/3/2018 18:16

Filter it hugh. It is amazing though how the uneducated seem to wish to advertise the fact!

[jimbobaroony] 01/3/2018 18:10

I credited QS99 as being able to read the latest RNS which states how many shares are in circulation.

YOU are getting personal and are coming over like the bully I suspect you are.

[hughwilson] 01/3/2018 18:03

And you are showing just how stupid you are.