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IMM Immupharma Plc

2.14
0.00 (0.00%)
Last Updated: 09:35:12
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Immupharma Plc LSE:IMM London Ordinary Share GB0033711010 ORD 1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 2.14 2.10 2.19 219,181 09:35:12
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Finance Services 0 -3.81M -0.0114 -1.88 7.13M

Immupharma PLC Interim Results (9046B)

26/09/2018 7:00am

UK Regulatory


Immupharma (LSE:IMM)
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TIDMIMM

RNS Number : 9046B

Immupharma PLC

26 September 2018

 
    26 SEPTEMBER 2018 
 

ImmuPharma PLC

("ImmuPharma" or the "Company")

INTERIM RESULTS ANNOUNCEMENT

for the six months ended 30 June 2018

ImmuPharma PLC (LSE:IMM), ("ImmuPharma" or the "Company"), the specialist drug discovery and development company, is pleased to announce its interim results for the six months ended 30 June 2018 (the "Period").

Key Highlights

Lupuzor(TM)

-- Lupuzor(TM) demonstrated a superior response rate over placebo (52.5% vs 44.6% "responders") in the primary analysis on the Full Analysis Set of all 202 patients. However, due to the high response rate in the placebo group, this superior response did not allow statistical significance to be reached (p = 0.2631) and the trial's primary end point was not met.

-- Across the whole study population, in those patients who had anti-dsDNA autoantibodies, Lupuzor(TM) demonstrated a superior response rate over placebo (61.5% vs 47.3%, p = 0.0967). Although these results were not statistically significant, further data analysis demonstrated that in the Europe cohort (130 patients) Lupuzor(TM) plus standard of care showed statistically significant reductions in disease activity compared to placebo plus standard of care in 79 patients who were anti-dsDNA autoantibody positive (71.1% vs 48.8%, p = 0.0218).

-- The study confirmed the outstanding safety profile of Lupuzor(TM) , with no serious adverse events reported.

-- As announced on 7 September 2018, agreement signed with a specialist provider to enter Lupuzor(TM) into a 'Managed Access Programme'.

   --      Open label extension study completes recruitment. 

Other programs

   --     Nucant (cancer) program - Clinical Development Collaboration with Incanthera Limited. 
   --     Peptide platform program / Ureka subsidiary - ImmuPharma to begin divestment process. 

Financial Position

   --     GBP10 million fundraising (before expenses) successfully completed in January 2018. 
   --     Stable financial performance over the Period, in line with market expectations 

o Net assets of GBP9.9 million (31 December 2017: GBP3.6 million)

o Loss for the period of GBP4.1 million (H1 2017: GBP3.0 million)

-- Research and Development expenses of GBP2.5 million (H1 2017: GBP2.3 million)

o Basic and diluted loss per share of 2.94p (H1 2017: 2.34p)

Appointment of new joint brokers

-- Stanford Capital Partners and SI Capital appointed as joint brokers, working in conjunction with current NOMAD and broker, Northland Capital Partners.

Commenting on the Interims and outlook Tim McCarthy, Chairman, said:

"The Board is pleased to announce the interim results for the six months ended 30 June 2018. It has been a busy period for the Board following the announcement of the Phase III trial results for Lupuzor in April 2018. We remain focused on delivering a business strategy which provides the optimum route forward for ImmuPharma and its shareholders, based on its current assets, resources and knowhow. We were obviously disappointed with the outcome of the Phase III trial results but are excited to be progressing the Managed Access Programme with a new strategic partner, which allows lupus patients early access to Lupuzor(TM) . In the medium term, we remain focussed on achieving the full regulatory approval of Lupuzor(TM) which we believe has the potential to be a ground breaking drug for lupus patients with blockbuster potential in commercial terms.

Our Nucant programme and Ureka subsidiary have been part of our portfolio for a number of years. We are equally excited by the potential of both. We believe the strategy we announced earlier this month, together with a robust financial position, will create enhanced value for shareholders going forward."

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014. ("MAR")

For further information please contact:

 
  ImmuPharma PLC                                + 44 (0) 20 7152 4080 
  Tim McCarthy, Chairman 
  Dimitri Dimitriou, Chief Executive 
   Officer 
  Tracy Weimar, Vice President, Operations 
   and Finance 
  Lisa Baderoon, Head of Investor Relations      + 44 (0) 7721 413496 
 
  Northland Capital Partners Limited, 
   Nomad & Joint Broker                          +44 (0) 20 3861 6625 
  David Hignell, Jamie Spotswood, Dugald 
   Carlean, Corporate Finance 
   Rob Rees, Corporate Broking 
  Stanford Capital Partners, Joint Broker 
   Patrick Claridge 
   Chris Coleman                                 +44 (0) 20 3815 8880 
  SI Capital, Joint Broker 
   Nick Emerson                                   +44 (0) 1483 413500 
 

CHAIRMAN'S STATEMENT

INTERIM HIGHLIGHTS

The first half of 2018 saw the completion of our pivotal Phase III trial for Lupuzor(TM) , our candidate for the treatment of lupus. Top-line results were announced on 17 April 2018 with further analysis provided on 29 May 2018. Following these results, ImmuPharma has recently signed an agreement with a specialist provider to distribute Lupuzor(TM) via a Managed Access Programme. This will allow lupus patients early access to Lupuzor(TM) prior to any regulatory filing.

ImmuPharma has, on 6 September 2018, signed a Heads of Terms on a clinical development collaboration for the Nucant cancer programme with Incanthera Limited, a specialist oncology development company. Further, following an extensive review, it has been decided that the Company's Ureka subsidiary which focuses on peptide treatments for metabolic disorders is not part of the ongoing strategy of ImmuPharma which is now fully focused on utilising its resources to develop late stage assets. Consequently, we are beginning the process of divesting Ureka.

In other developments, we were pleased to have completed a successful fund raising of GBP10 million (before expenses) in January 2018. The fund raising was supported by long term shareholders and the addition of new institutional and private investors.

Lupuzor(TM) Phase III results and next steps

The Phase III trial was a double-blind, randomised, placebo-controlled trial. The study involved patients being dosed for one year, receiving 0.2mg once per month subcutaneously. 293 patients were screened illustrating the demand from physicians for a new, safe and effective treatment for lupus. Of these, the required 202 patients were successfully recruited and randomised (dosed). Patients participated in the trial in 7 countries across 28 sites.

The clinical trial was undertaken primarily by Simbec-Orion, an international clinical research organisation, who specialises in rare and orphan conditions and has previous direct experience in lupus trials. This was a pivotal study designed to demonstrate the safety and efficacy of Lupuzor(TM) .

Lupuzor(TM) demonstrated a superior response rate over placebo (52.5% vs 44.6% "responders") in the primary analysis on the Full Analysis Set of all 202 patients. However, due to the high response rate in the placebo group, this superior response did not allow statistical significance to be reached (p = 0.2631) and the trial's primary end point was not met.

Across the whole study population, in those patients who had anti-dsDNA autoantibodies, Lupuzor(TM) demonstrated a superior response rate over placebo (61.5% vs 47.3%, p = 0.0967). Although these results were not statistically significant, further data analysis demonstrated that in the Europe cohort (130 patients) Lupuzor(TM) plus standard of care showed statistically significant reductions in disease activity compared to placebo plus standard of care in 79 patients who were anti-dsDNA autoantibody positive (71.1% vs 48.8%, p = 0.0218).

The study confirmed the outstanding safety profile of Lupuzor(TM) , with no serious adverse events reported.

Scientific literature indicates that approximately 60% - 70% of patients diagnosed for lupus are anti-dsDNA autoantibody positive. These proportions were seen in the Europe cohort (60.8% of patients) and could therefore be considered as representative of the overall lupus population.

In those patients who were anti-dsDNA autoantibody negative, there was almost no difference in disease activity reduction between the active group and the comparator group. Anti-dsDNA autoantibodies are a recognised biomarker for Systemic Lupus Erythematosus.

This finding indicates that the activity of Lupuzor(TM) could be correlated with the presence of anti-dsDNA autoantibodies in lupus patients. ImmuPharma believes that predictive biomarkers, such as anti-dsDNA autoantibodies, could allow identification of patients that are more likely to respond positively to treatment with Lupuzor(TM) .

Lupuzor(TM) next steps - Managed Access Program

ImmuPharma is planning to move forward with a Managed Access Program for Lupuzor(TM) . Recognising that lupus is a disease with significant unmet medical need and given the advanced level of clinical trial investigation completed, ImmuPharma would like to meet demand for access to Lupuzor(TM) by lupus patients who, together with their physicians, request it.

Extension study

The Lupuzor(TM) extension study, which was announced on 18 January 2018, is continuing and recruitment is now complete with a total of 62 patients eligible from the original Phase III trial. We believe that this will provide more valuable information on the potential efficacy and safety of Lupuzor(TM) . The study is anticipated to report results in Q2 2019.

Nucant Platform

A number of options have been under review to develop the Company's Nucant cancer programme, which has demonstrated promising results in two Phase I trials (safety and dose-finding studies).

In order to progress the programme, on 6 September 2018 ImmuPharma signed Heads of Terms on a clinical development collaboration for the Nucant cancer programme, with Incanthera Limited ("Incanthera"), a specialist oncology development company.

Key highlights of the Heads of Terms are summarised below:

-- Incanthera, based on its positive due-diligence on the Company's Nucant technology, will license in and take up the continued clinical development of the Nucant cancer programme as an integral part of its own cancer development portfolio.

-- As an integral part of the collaboration, upon signing the Heads of Terms, ImmuPharma has invested GBP2m into Incanthera by subscribing for 363,637 new ordinary Incanthera shares at a price of GBP5.50 per share. This investment values Incanthera at a pre-money valuation of approximately GBP10m and is consistent with the most recent funding round that Incanthera completed in March 2018. Following this investment, ImmuPharma will have a circa 16% shareholding in Incanthera.

-- ImmuPharma has granted Incanthera a period of exclusivity until 31 December 2018, during which the Company and Incanthera will finalise the terms of a Definitive Licence Agreement for the Nucant technology. These terms are expected to include, but will not be limited to the following:

o Incanthera will pay a licence payment to ImmuPharma of GBP1 million, with this payment to be made via the issuance of new ordinary shares in Incanthera. This payment in shares is separate and will be in addition to the shareholding which Immupharma currently holds as described above;

o Incanthera will be responsible for all of the development costs for the Nucant programme; and,

o All future commercialisation revenues will be shared equally between the two companies.

Ureka - Divestment process

Ureka, ImmuPharma's wholly owned subsidiary, based in Bordeaux, which is carrying out research into treatments for Type II diabetes and NASH (Non-Alcoholic-Steato-Hepatitis) has recently demonstrated success in recognised preclinical studies.

Following an extensive review by ImmuPharma's Board of directors, it has been decided that Ureka, whilst having exciting and innovative technologies, is not part of the ongoing strategy of ImmuPharma, which is now fully focused on utilising its resources to develop late stage assets.

As such, ImmuPharma, with its advisors, will now commence a process of considering all opportunities to divest Ureka. The intention is to allow ImmuPharma to divest Ureka, whilst still retaining an interest in any future commercial success.

Financial Review

ImmuPharma's cash balance at 30 June 2018 was GBP9.02 million (GBP2.73 million at 31 December 2017, GBP3.13 million at 30 June 2017). Basic and diluted loss per share were 2.94p and 2.94p respectively (30 June 2017: 2.34p and 2.34p). In line with the Company's current policy, no interim dividend is proposed.

Operating loss for the Period was GBP4.1 million (GBP3.2 million for the six months ended 30 June 2017). Research and development expenditure in the Period was GBP2.5 million (GBP2.3 million for the six months ended 30 June 2017) reflecting primarily the expenditure related to the Lupuzor(TM) Phase III clinical trial. Administrative expenses were GBP1.0 million during the Period (GBP0.8 million for the six months ended 30 June 2017). The share based expense was GBP775k (GBP131k for the period ended 30 June 2017) which includes a reduction for the National Insurance provision which was nil due to the decrease in share price from 31 December 2017 to 30 June 2018.

Given the stage of ImmuPharma's development, the fact that losses have continued to be made is to be expected since there is minimal revenue and business activity is concerned with significant investment in the form of clinical development expenditure, in addition to maintaining the infrastructure of the Company.

Current Activities and Outlook

The Board has been focused on delivering a business strategy which provides the optimum route forward for ImmuPharma and its shareholders, based on its current assets, resources and knowhow. We are excited to be progressing the Managed Access Programme which allows lupus patients early access to Lupuzor(TM) . In the medium term, we remain focussed on achieving the full regulatory approval of Lupuzor(TM) which we believe has the potential to be a ground breaking drug for lupus patients with blockbuster potential in commercial terms.

Our Nucant programme and Ureka subsidiary have been part of our portfolio for a number of years. We are equally excited by the potential of both. We believe the strategy we are pursuing with the collaboration with Incanthera Limited for the Nucant and for divestment of Ureka will create enhance value for shareholders going forward.

The Board would like to thank its shareholders, both longstanding and those who participated in the January 2018 fundraising, for their support as well as its staff, corporate and scientific advisers including Simbec-Orion and the CNRS (Centre Nationale de la Recherche Scientifique) for their continued collaboration.

Tim McCarthy

Chairman

ImmuPharma PLC

CONSOLIDATED INCOME STATEMENT

FOR THE PERIODED 30 JUNE 2018

 
                                    Note       Unaudited         Audited      Unaudited 
                                                6 months            Year       6 months 
                                                   ended           ended          ended 
                                                 30 June     31 December        30 June 
                                                    2018            2017           2017 
                                                     GBP             GBP            GBP 
  Continuing operations 
  Revenue                            1            73,392         150,462         86,504 
  Research and development 
   expenses                                  (2,455,490)     (5,121,388)    (2,345,815) 
  Administrative expenses                      (992,085)     (1,520,356)      (796,403) 
  Share based expense                          (775,135)       (742,752)      (131,237) 
 
  Operating loss                             (4,149,318)     (7,234,034)    (3,186,951) 
 
  Finance costs                                 (29,425)         (3,858)          (375) 
  Finance income                                   6,077         240,447        153,915 
 
 
  Loss before taxation                       (4,172,666)     (6,997,445)    (3,033,411) 
 
  Tax                                            110,237         774,244          (485) 
 
 
  Loss for the period                        (4,062,429)     (6,223,201)    (3,033,896) 
 
 
  Attributable to: 
  Equity holders of the parent 
   company                                   (4,062,429)     (6,223,201)    (3,033,896) 
 
 
  Loss per ordinary share 
 
  Basic and diluted                  2           (2.94)p         (4.75)p        (2.34)p 
 
 

ImmuPharma PLC

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME

FOR THE PERIODED 30 JUNE 2018

 
                                             Unaudited        Audited      Unaudited 
                                              6 months           Year       6 months 
                                                 ended       ended 31          ended 
                                               30 June       December        30 June 
                                                  2018           2017           2017 
                                                   GBP            GBP            GBP 
 
  Loss for the financial period            (4,062,429)    (6,223,201)    (3,033,896) 
 
 
  Other comprehensive income 
  Items that may be reclassified 
   subsequently to profit or loss: 
  Exchange differences on translation 
   of foreign operations                        29,459       (91,568)       (56,133) 
 
 
  Total items that may be reclassified 
   subsequently to profit or loss               29,459       (91,568)       (56,133) 
 
  Other comprehensive loss for 
   the period                                   29,459       (91,568)       (56,133) 
 
 
  Total comprehensive loss for 
   the period                              (4,032,970)    (6,314,769)    (3,090,029) 
 
 

ImmuPharma PLC

CONSOLIDATED STATEMENT OF FINANCIAL POSITION

AS AT 30 JUNE 2018

 
                                    Note        Unaudited         Audited       Unaudited 
                                                  30 June     31 December         30 June 
                                                     2018            2017            2017 
                                                      GBP             GBP             GBP 
  Non-current assets 
  Intangible assets                               481,667         482,268         497,585 
  Property, plant and equipment                   120,675         161,399         192,573 
 
 
  Total non-current assets                        602,342         643,667         690,158 
 
 
  Current assets 
  Trade and other receivables                   1,174,720       1,644,128       2,439,143 
  Derivative financial asset                            -               -         943,861 
  Cash and cash equivalents                     9,015,630       2,729,468       3,131,595 
 
 
  Total current assets                         10,190,350       4,373,596       6,514,599 
 
 
  Current liabilities 
  Financial liabilities - 
   borrowings                                     138,214         142,393         119,430 
  Trade and other payables                        737,035         929,569         473,867 
  Provisions                                            -          57,517          33,162 
 
 
  Total current liabilities                       875,249       1,129,479         626,459 
 
 
  Net current assets                            9,315,101       3,244,117       5,888,140 
 
 
  Non-current liabilities 
  Financial liabilities - 
   borrowings                                      61,209         117,297         170,232 
  Provisions                                            -         195,989               - 
 
 
  Net assets                                    9,856,234       3,574,498       6,480,066 
 
 
  EQUITY 
  Ordinary shares                              13,946,744      13,252,299      13,252,298 
  Share premium                                27,320,143      18,728,519      18,728,519 
  Merger reserve                                  106,148         106,148         106,148 
  Other reserves                              (1,902,921)     (2,961,017)     (3,316,753) 
  Retained earnings                          (29,613,880)    (25,551,451)    (22,362,146) 
 
 
  Total equity                                  9,856,234       3,574,498       6,408,066 
 
 

ImmuPharma PLC

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

FOR THE PERIODED 30 JUNE 2018

 
                                                                  Other         Other reserves        Other 
                                                  Merger     reserves -                      -     reserves        Retained 
                                                 reserve    Acquisition            Translation            -        Earnings 
                                                                reserve                Reserve       Equity 
                                                                                                     shares 
                      Share            Share                                                          to be                          Total 
                      capital        premium                                                         issued                         equity 
                           GBP           GBP         GBP            GBP                    GBP          GBP             GBP            GBP 
   At 1 January 
    2017            12,463,836    15,678,054     106,148    (3,541,203)            (1,609.673)    1,777,131    (19.328.250)      5,546,043 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (3,033,896)    (3,033,896) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -               (56,133)            -               -       (56,133) 
   New issue of 
    equity 
    capital            788,462     3,311,542           -              -                      -            -               -      4,100,004 
   Cost of new 
    issue of 
    equity 
    capital                  -     (261,077)           -              -                      -            -               -      (261,077) 
   Share based 
    payments                 -             -           -              -                      -      113,125               -        113,125 
                  ------------  ------------  ----------  -------------  ---------------------  -----------  --------------  ------------- 
 
   At 30 June 
    2017            13,252,298    18,728,519     106,148    (3,541,203)            (1,665,806)    1,890,256    (22,362,146)      6,408,066 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
 
   At 1 January 
    2017            12,463,836    15,678,054     106,148    (3,541,203)            (1,609,673)    1,777,131    (19,328,250)      5,546,043 
 
   Loss for the 
    financial 
    year                     -             -           -              -                      -            -     (6,223,201)    (6,223,201) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -               (91,568)            -               -       (91,568) 
   New issue of 
    equity 
    capital            788,463     3,311,542           -              -                      -            -               -      4,100,005 
   Cost of new 
    issue of 
    equity 
    capital                  -     (261,077)           -              -                      -            -               -      (261,077) 
   Share based 
    payments                 -             -           -              -                      -      504,296               -        504,296 
                  ------------  ------------  ----------  -------------  ---------------------  -----------  --------------  ------------- 
 
   At 31 
    December 
    2017 
    & 1 January 
    2018            13,252,299    18,728,519     106,148    (3,541,203)            (1,701,241)    2,281,427    (25,551,451)      3,574,498 
 
   Loss for the 
    financial 
    period                   -             -           -              -                      -            -     (4,062,429)    (4,062,429) 
   Exchange 
    differences 
    on 
    translation 
    of foreign 
    operations               -             -           -              -                 29,459            -               -         29,459 
   New issue of 
    equity 
    capital            694,445     9,305,555           -              -                      -            -               -    10,000,000 
   Cost of new 
    issue of 
    equity 
    capital                  -     (713,931)           -              -                      -            -               -      (713,931) 
   Share based 
    payments                 -             -           -              -                      -    1,028,637               -     1,028,637 
 
   At 30 June 
    2018            13,946,744    27,320,143     106,148    (3,541,203)            (1,671,782)    3,310,064    (29,613,880)      9,856,234 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
   Attributable 
   to:- 
 
   Equity 
    holders of 
    the 
    parent 
    company         13,946,744    27,320,143     106,148    (3,541,203)            (1,671,782)    3,310,064    (29,613,880)      9,856,234 
                  ============  ============  ==========  =============  =====================  ===========  ==============  ============= 
 
 

ImmuPharma PLC

CONSOLIDATED STATEMENT OF CASHFLOWS

FOR THE PERIODED 30 JUNE 2018

 
                                        Note            Unaudited         Audited      Unaudited 
                                                         6 months            Year       6 months 
                                                            ended           ended          ended 
                                                          30 June     31 December        30 June 
                                                             2018            2017           2017 
                                                              GBP             GBP            GBP 
  Cash flows from operating 
   activities 
  Cash used in operations                3            (3,150,500)     (5,439,079)    (3,200,329) 
  Tax                                                     213,724       1,021,915          6,680 
  Interest paid                                           (2,423)         (3,858)          (375) 
 
   Net cash used in operating 
    activities                                        (2,939,199)     (4,421,022)    (3,194,024) 
 
 
  Investing activities 
  Purchase of property, 
   plant and equipment                                    (7,946)        (25,491)        (1,595) 
  Interest received                                         6,077             772            170 
 
 
  Net cash used in investing 
   activities                                             (1,869)        (24,719)        (1,425) 
 
 
  Financing activities 
  (Decrease)/increase in bank 
   overdraft                                                (122)           (290)          (138) 
  Loan repayments                                        (58,615)       (114,386)       (80,447) 
  Gross proceeds from issue 
   of new share capital                                10,000,000       4,100,005      4,100,004 
  Settlements from sharing 
   agreement                                                    -       1,667,380        682,360 
  Share capital issue costs                             (713,931)       (261,077)      (261,077) 
 
 
  Net cash generated from financing 
   activities                                           9,227,332       5,391,632      4,440,702 
 
 
  Net increase in cash and 
   cash equivalents                                     6,286,264         945,891      1,245,253 
  Cash and cash equivalents 
   at start of period                                   2,729,468       1,876,718      1,876,718 
   Effects of exchange rates 
    on cash and 
    cash equivalents                                        (102)        (93,141)          9,624 
 
   Cash and cash equivalents 
    at end of period                                    9,015,630       2,729,468      3,131,595 
 
 
 

ImmuPharma PLC

NOTES TO THE CONSOLIDATED INTERIM ACCOUNTS FOR THE PERIODED 30 JUNE 2018

   1          ACCOUNTING POLICIES 

Basis of preparation

The interim financial information in this report has been prepared using accounting policies consistent with IFRS as adopted by the European Union. IFRS is subject to amendment and interpretation by the International Accounting Standards Board (IASB) and the IFRS Interpretations Committee and there is an ongoing process of review and endorsement by the European Commission. The financial information has been prepared on the basis of IFRS to be adopted by the European Union and applicable as at 31 December 2018. The Group has chosen not to adopt IAS 34 "Interim Financial Statements" in preparing the interim financial information.

The accounting policies applied are consistent with those that were applied to the financial statements for the year ending 31 December 2017, with the exception of IFRS 9 "Financial Instruments" and IFRS 15 "Revenue from Contracts with Customers" which are new standards applicable mandatory for the year ended 31 December 2018. These new standards will not have a material impact on the financial statements.

Non-Statutory accounts

The financial information set out in this interim report does not constitute the Group's statutory accounts, within the meaning of Section 434 of the Companies Act 2006. The statutory accounts for the year ended 31 December 2017 have been filed with Registrar of Companies. The auditors reported on those accounts; their report was unqualified, did not contain a statement under either Section 498 (2) or Section 498 (3) of the Companies Act 2006 and did not include references to any matters to which the auditor drew attention by way of emphasis. The financial information for the 6 months ended 30 June 2018 and 30 June 2017 is unaudited.

Copies of this statement will be available on the Company's website - www.immupharma.com.

   2              LOSS PER SHARE 
 
                                          Unaudited         Audited      Unaudited 
                                           6 months      Year ended       6 months 
                                           ended 30     31 December          ended 
                                          June 2018            2017        30 June 
                                                                              2017 
                                                GBP             GBP            GBP 
 
  Loss 
  Loss for the purposes of basic 
   and diluted loss per share 
   being net loss attributable 
   to equity shareholders               (4,062,429)     (6,223,201)    (3,033,896) 
 
 
  Number of shares 
  Weighted average number of 
   ordinary shares for the purposes 
   of basic loss per share              138,201,316     130,902,857    129,517,245 
 
 
   Basic loss per share                     (2.94)p         (4.75)p        (2.34)p 
 
 
 
  Diluted loss per share                    (2.94)p         (4.75)p        (2.34)p 
 
 
 

There is no difference between basic loss per share and diluted loss per share as the share options and warrants are anti-dilutive.

The ImmuPharma group has granted share options in respect of shares to be issued.

 
  3                                 CASH USED IN OPERATIONS 
                                                Unaudited         Audited       Unaudited 
                                                 6 months      Year ended        6 months 
                                                    ended     31 December           ended 
                                                  30 June            2017         30 June 
                                                     2018                            2017 
                                                      GBP             GBP             GBP 
 
   Operating loss                             (4,149,318)     (7,234,034)     (3,186,951) 
   Depreciation & amortisation                     81,424         138,198          61,954 
   Share based payments                         1,028,637         504,296         113,125 
   Decrease in trade & other 
    receivables                                   358,921         643,466          34,004 
   (Decrease)/increase in trade 
    & other payables                            (189,656)         143,378       (322,963) 
   (Decrease)/increase 
    in provisions                               (253,506)         238,456          18,112 
   Gain/(loss) on foreign 
    exchange                                     (27,002)         127,161          82,390 
 
    Cash used in operations                   (3,150,500)     (5,439,079)     (3,200,329) 
 
 
 
 
  4    SUBSEQUENT EVENTS 
 
       On 7 September 2018, ImmuPharma announced that a Heads of 
        Terms agreement was signed with Incanthera Limited. Under 
        the Heads of Terms agreement, Incanthera Limited will license 
        in and take up the continued clinical development of the 
        Nucant cancer programme as an integral part of its own cancer 
        development portfolio. As part of the Heads of Terms, ImmuPharma 
        has invested GBP2 million into Incanthera Limited by subscribing 
        for 363,637 new ordinary Incanthera shares at a price of 
        GBP5.50 per share. Following this investment, ImmuPharma 
        will have approximately 16% shareholding in Incanthera Limited. 
        Under the Heads of Terms, ImmuPharma has granted Incanthera 
        Limited a period of exclusivity until 31 December 2018, 
        during which the two companies will finalise terms of a 
        Definitive License Agreement for the Nucant technology. 
        These terms are expected to include, but will not be limited 
        to Incanthera Limited paying a license payment to ImmuPharma 
        of GBP1 million, with this payment being made via the issuance 
        of new ordinary shares in Incanthera Limited. It is also 
        planned to include confirmation that Incanthera Limited 
        will be responsible for all of the development costs of 
        the Nucant programme and confirmation that all future commercialisation 
        revenues will be shared equally between the two companies. 
 

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

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