Good news today re. successful Phase lll Linerixibat results.
There's another 23 Phase lll candidates in the pipeline, many of which are very important medicines, with indications:
Urogenital gonorrhoea (GC)
Chronic hepatitis B virus infection
COPD
2L Non-small cell lung cancer combination with Jemperli (dostarlimab) and docetaxel
Prevention of invasive disease caused by N. meninigitidis serogroup B in individuals 2 months of age and older (US)
Frontotemporal dementia (FTD) due to heterozygous mutations in the progranulin gene
Asthma
Complicated urinary tract infection (cUTI)
Invasive candidiasis
.... and others.
The 'market' has to acknowledge these breakthroughs soon .... ;0) |
Gecko
I will qualify the remark just for you
'two short'
Satisfied |
Are you trying to initiate a war here Gecko ??
Plank! |
Yawn, your TDS is boring Jubber. |
The general market has got a new strain of Trump/Kennedy induced diarrhoea
I have stocked up on immodium and Tenna Pants and a m looking to adding a few bargains
Good luck |
Yes good news followed by bad news, daily. |
Linerixibat shows positive Phase III results in cholestatic pruritus (relentless itch) in primary biliary cholangitis (PBC)
· Primary endpoint met with a statistically significant improvement in itch over 24 weeks compared with placebo
· Linerixibat has the potential to be the first global therapy indicated to treat itch in PBC
· Cholestatic pruritus is one of the most common symptoms of PBC, an autoimmune disease that can lead to liver failure
GSK plc (LSE/NYSE: GSK) today announced positive headline results of GLISTEN, the ongoing global phase III clinical trial evaluating linerixibat, an investigational targeted inhibitor of the ileal bile acid transporter (IBAT), in adults with cholestatic pruritus (relentless itch) associated with primary biliary cholangitis (PBC), a rare autoimmune liver disease. |
 I'll add my two pennyworth
Way back at the beginning of Covid I had the Astra Zenaca Jab(I have a compromised immune system from an earlier bout with CML)
Anyway about a week later went for my regular blood test and was phoned same afternoon and told to get to my nearest hospital.
The same day was then taken by ambulance to UCH London where I spent just over a week before being considered well enough to go home. (still have to have regular blood tests)
My platelet count had fallen to 6 (I was struggling to walk the dog round the block, was short of breath)
I had contracted TTP and consider myself very fortunate to still be here.
I don't blame anyone or any body.
The vaccine was rushed out at very short notice without the customary checks which would have picked up the side effects only apparent afterwards.
I have complete trust in the medical expertise currently available and continue to have my regular covid jabs.
As I said I consider Trump and co to be grandstanding chumps but will continue to avoid Astra Zeneca as I believe this panic has been initiated by the furore they are currently embroiled in in China ,
Anyway that is my personal perspective and why I look upon this current situation as a potential buying opportunity.
Its all about levels.
Good luck everyone |
Interesting points made here. I'm assuming by individuals who hold significant amounts.?..the fact it has become more noteably political is intriguing.
I read the news today and even the msm outlets are struggling when certain investment companies have sold 100s of millions here ...but they add certain financial companies have added...literally shares worth 10 to 15k!! This is going South big time.
I think it was rather political with certain world leaders who pushed the new type 'treatments'.
Every action has a reaction.
Any individual or institution is selling here because its going to make zantac look like a blip. This is big imo.
GSK needs real novel ipr...such as autoimmune and chk1...the very same ones merck are after...oh and j snd j with the talc issue...
Just saying my point. Called this 6 months ago.
Makes you wonder why gsk did the haleon split...... |
#743. What has that post got to do with GSK?
Not one of your best. |
Dr Biotech
Post 33734
First UK case was jan 2020. Part of the problem with Covid whilst obviously a serious virus, was the misinformation given by the likes of Zero Hedge and reposted by useful idiots on other forums. Doing Russia's bidding, but too thick to realise. Would have helped of course if the Chinese had been more honest and open
First OFFICIALLY Recorded case you'll find.
I had ALL the recognisable symptoms that were often parroted out in mid 2020 onwards.
It has also shown up in Spanish "sewage samples" earlier than Jan 2020 - circa September/October fyi so whilst not officially recognised, that doesn't mean it was not circulating.
And people like Dr Pierre Kory, Dr Peter McCullough, Dr Chris Martenson, and co are not "useful idiots"
I'll take their advice over yours any day.
If you want to see how much damage was done by vaccines compared to Covid then you need to look at populations that had the vaccine first (ie New Zealand). What also gets me is that there were of course several different vaccines that had different modes of action - according to the antivaxxers the all seem to cause the same issues, thats highly unlikely from a physiology point of view.
Yawn,the usual trope that if you didnt take your Covid vaccine you're an anti vaxxer.
What a load of cobblers.
The Worst vaccines were Moderna (Highest dosage mRNA side) then Pfizer.
AZN's Adenovirus caused blood clots.
If you review Dr John Campbells videos on such you'll see just how his opinion changed over the years. He provides decent sources in all videos.
Of course for the best protection you need to have a vaccine with a similar antigen to the prevalent strain. A vaccine will do that, or of course a recent covid infection. Testing for the latest antibodies isn't a quick or easy process.
For a virus with a fatality rate of sub 1% for those aged 0-60 why is there the need for a vaccine?
And once again NO I am not an anti vaxxer.
Had all my vaccines over the years - BCG, Yellow Fever etc.
So you don't dispute my:
GeckotheGlorious15 Nov '24 - 17:44 - 33707 of 33733
FYI. Each time a vaccine came out it was for a strain that was dominant 6 to 9 months prior!!!!! That's why so many who get a Covid 19 vaccine still get Covid!! Because theyre vaccinated against the wrong strain.
Additionally, if you've had Covid and recovered your immune system is well set - you dont need a forced Covid19 vaccine. |
That's ok - they'll raise it again after the shareprice reaches 1500p, 1700p etc.
Perhaps, in this age of AI, they could automate the process to save a bit of money ? |
Wow, I know analysts are useless but that's a big cut. |
These brokers are good for nothing at all. |
These brokers are so clever cutting price targets after the event...10yrs old could that... |
Deutsche Bank cuts target price to 1350p from 1700p |
Further falls as Tariffs hit.
Too Risky as lower levels tested.
How Low How Soon as Drug Uptake looking to Collapse....as USA lead the negative sentiment!! |
is RFK jnr's appointment likely to be acceptable to and confirmed by congress? It seems even some Republican members are extremely sceptical of the anti-vax and FDA rhetoric, believing that vaccination is probably the biggest medical advance of all time after clean drinking water. |
I had this sell off attributed to the legal difficulties currently being experienced by AZN big wigs in China,this was then followed by the appointment of a Health Secretly in the USA who is as deluded as trump.
I will just bide my time conserve my funds and top up when I feel it is appropriate but not at this present moment in time.
'This too shall pass'. But my holdings might take a beating in the meantime.
Grow some fellow investors. |
First UK case was jan 2020. Part of the problem with Covid whilst obviously a serious virus, was the misinformation given by the likes of Zero Hedge and reposted by useful idiots on other forums. Doing Russia's bidding, but too thick to realise. Would have helped of course if the Chinese had been more honest and open.
If you want to see how much damage was done by vaccines compared to Covid then you need to look at populations that had the vaccine first (ie New Zealand). What also gets me is that there were of course several different vaccines that had different modes of action - according to the antivaxxers the all seem to cause the same issues, thats highly unlikely from a physiology point of view.
Of course for the best protection you need to have a vaccine with a similar antigen to the prevalent strain. A vaccine will do that, or of course a recent covid infection. Testing for the latest antibodies isn't a quick or easy process.
GeckotheGlorious15 Nov '24 - 17:44 - 33707 of 33733
I had Covid in December 2019, recovered.
Why do I need a vaccine oh intelligent one?
FYI. Each time a vaccine came out it was for a strain that was dominant 6 to 9 months prior!!!!! That's why so many who get a Covid 19 vaccine still get Covid!! Because theyre vaccinated against the wrong strain.
Additionally, if you've had Covid and recovered your immune system is well set - you dont need a forced Covid19 vaccine.
After things changed. Sadly you have no such actual knowledge |
Washingmachine 16 Nov '24 - 07:08 - 33722
" I can see GSK getting slammed from here
Wouldn’t surprise me
3 to 500 pence
And I’m serious "
Just entered the rinse cycle? |
And he’s still had a far better life than 99 percent .. |
Oh and Taylor swift for the teenys |
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