Diurnal Share Discussion Threads

[mw8156] 13/2/2022 23:02

Bradders

can imagine the chronocort treatment is designed to capture more closely the circadian rhythm of cortisol secretion particularly to start increasing cortisol levels in the early morning before the subject awakens which the present bolus hydrocortisone on waking fails to do: so from that point of view it may be more physiological, so patients may report greater early morning alertness and may reduce the secondary side effects of bolus cortisol including on glucose intolerance, Bolus cortisol in the evening, the present therapy, is not physiological and can cause problems with getting to sleep if taken too late in the day and possibly with glucose metabolism.

certainly, I feel sleepy in the morning for an hour or two on waking, especially at this time of year, but don't we all!
chronocort, if it works as intended, might improve this symptom.

Whether all this will be regarded as transformational and remedy areas of high unmet need is debatable in my view. However, it may in the long run cut down the incidence of type 2 diabetes mellitus secondary to longstanding bolus cortisol therapy. there is also a much higher incidence of type 1 diabetes, not sure whether it would have an effect on that also. Average age at death of Addison's in the Norwegian study from years ago was 64....

[bradders51] 11/2/2022 14:44

mw.... Are you saying that the needs ARE being met? Are you happy with your present treatment may I ask?
Good luck to you either way mate.

[mw8156] 11/2/2022 10:39

would have thought the drug trials, which have no doubt been delayed by covid, will come through in the end and be a success,
trying to find out about the champain trial, only 50 participants, said to counter an area of high unmet medical need in adult AI/Addison's.
As a patient with the condition for the last 43 years, I rather doubt the high unmet medical need bit...

[glasswala] 11/2/2022 08:43

Where is the R & D update. Its over 1 week delay already and not a bean has been said about it

[abbynat] 09/2/2022 11:39

seems to be fashionable currently among aim stocks. particularly the ones who have had a bashing or are languishing even lower.
novacyt is one, who issued a similar rns recently, and a few oil/mining stocks.
that's the risk we all take when we invest, sorry, that's the wrong word, i mean buy on this aimless mkt!

[daveboy19] 09/2/2022 08:10

I'd rather see the £1.25 first, before they remind us of how much more cash they will be personally parking !!

[best1467] 09/2/2022 07:58

CAH) Efmody(R) cumulative sales up to 31 December 2024 in line with Company forecasts
So sales have to meet the company forecasts which I presume will be based on the the house broker figures which do look reasonable going forward

[best1467] 09/2/2022 07:53

Well at leat we should all be reasonably happy if the stock price reaches 125p

[daveboy19] 09/2/2022 07:42

Totally agree with you there. Is this not just rubbing salt in our wounds? Ffs, no profit or info or anything. No performance in 4 years, but hey here's news of all the extra free shares we have awarded ourselves! Might see if they have any job vacancies available. Truly audacious.

[glasswala] 09/2/2022 07:30

Where are the sales figures. Forget profits....

[glasswala] 09/2/2022 07:28

They have achieved no performance for sharehilders but want rewards all the same. Talk about greedy bast@$d

[best1467] 01/2/2022 07:45

A decent research note and like the mention of competition which looks positive for both

[simon_64] 31/1/2022 18:03

Once this covid crisis is done and dusted is when we will see the real growth and potential and that is why the share price is languishing.

Things can turn on a sixpence on the stock market and i am happy to hold here, this one does what it says on the tin.

[weatherman] 26/1/2022 14:44

Thanks for link. Calvine are forecasting turnover of £10.5m this year (to end of June), £33.8m FY23 - current DCF NPV they suggest 241p (from last year Edison had 149p, Hardman 141p).

Annualised sales figures suggest Alkindi is doing £3.5m, while Efmody is £1.6m; in 3 months Efmody had £0.4m turnover. Without growth that is £5.1m, but with growth it is not hard to see Edison forecast turnover £7.9m met for this FY - all looks on target.

[bradders51] 26/1/2022 14:22

Calvine Partners update note.
hxxps://www.calvinepartners.com/post/diurnal-group-trading-update-ahead-of-r-d-day?utm_campaign=9b044854-773e-42c6-96c5-0354145c5983&utm_source=so&utm_medium=mail&cid=19ac48a6-4478-4665-a825-118f26f77efd

Diurnal Group is a client of Calvine Partners, and as such, this publication is not independent and should be considered a marketing communication under FCA Rules, blah, blah

[mufprat] 26/1/2022 14:22

Whilst progress is for sure being made, albeit at a snail pace, six monthly sales of £2M is hardly what you'd expect from a £100M mkt cap company. For sure DNL is a slow burner. Ho hum.

[simon_64] 26/1/2022 11:12

daveboy

I know how you feel, not about this one but many i have held & still hold a few of the m over the years.

Most of them worked out in the end and multi-bagged a few didn't.

This is a good un. ATB.

[daveboy19] 26/1/2022 08:26

Lol, yesterday's 1p back ! Hilarious. Only another 2p to go and I will be back to what I paid, 4 years ago!
Love minnie x

[bradders51] 26/1/2022 08:18

The results might even please some of the moaning minnies on here.
Some hope of that I guess :-)

[best1467] 26/1/2022 08:05

Royalty income from Alton looks to be around 5000k so not sure on the percentage without looking back but low teens from memory so possibly looking at around 10/12 million and they stated 100million market size above brokers comment of 80million with the increasing of the sales team of Alton through the co promotion sales initiative things looking ok stateside.
Alkindi sales growing nicely in key region’s with other territories coming on line so a decent update with continued acceleration of growth moving forward