Cyprotex Share Discussion Threads

[husbod] 02/9/2010 20:46

She doesn't know buywell altho she regularly asks me if the earth moved. I have absolutely no idea of what she's talking about.

[cotton4] 02/9/2010 16:31

As of 18th August 2010, the following held shareholdings in excess of 3%:

- Douglas Bates (27,668,719 - 12.37%)

- Intercapital Private Group Ltd (27,024,465 - 12.08%)

- Katya Tsaioun (24,133,006 - 10.79%)

- R. J. Koch (16,748,868 - 7.49%)

- D. Leahy (10,401,600 - 4.65%)

- G.L.A. Dow (9,065,727 - 4.05%)

- R. Sneller (9,000,000 - 4.02%)

- Octopus Investments Nominees Limited (8,085,000 - 3.61%)

- R. Long (8,000,000 - 3.58%)


As of 18 August 2010, the directorate shareholdings were:

- S. Harris (1,507,142 - 0.67%)

- A. D. Baxter (1,067,685 - 0.48%)

- J. Dootson (589,285 - 0.26%)

- Katya Tsaioun (24,133,006 - 10.79%)

- Douglas Bates (27,668,719 - 12.37%)

[buywell2] 02/9/2010 15:45

Husbod ..... the man that can move the market

What does your misses think of that ?

[husbod] 02/9/2010 13:10

Bought a few more (and moved the market - it is still possible!)but stopping now for the moment to see how the next few months pan out.

Last chance to buy below 6p?

[cotton4] 02/9/2010 12:34

Welcome on board sparty1. If you are prepared to wait, I don't think you will be dissappointed.

[sparty1] 02/9/2010 12:05

Liking the progress here
and have bought in today. Been hovering over the button for some time.Nice addition to my tiny med portfolio.Just the 50K to start with.



Some interesting chat....interesting aquisitions,big market out there particularly in the states.Backing the man not the company............
GL all.

[buywell2] 02/9/2010 10:12

I think this is a good idea ..... a very good PRO-ACTIVE move

I like pro-active moves ..... and just look at the weight of some of those speakers .... but little old Cyprotex are going to make it happen.

I will be very interested to read up on how many attended and what went down in due course.

One would hope that attendees will be impressed by what they see and hear and bring their pens along with them.


your speakers for our 2 events

Day One
Cyprotex Introduction to ADME Training Course September 22nd, 2010. 1.00pm - 5.00pm

Day two
6th North American Drug Discovery Workshop September 23rd, 2010. 8.00am - 5.30pm


Free registration

RSVP before September 10th, 2010




Day One. ADME Training Course

Clive Dilworth
Director of Scientific Operations (UK), Cyprotex Discovery

Michael Griffin
Senior Principal Scientist, Cyprotex Discovery

Day Two. Drug Discovery Workshop

Edward Kerns
Consultant, Discovery ADME
Integrating in vitro and in vivo DMPK studies to guide structure optimization in drug discovery

Konstantine Skordos
Section Manager, DMPK, GSK
Reducing late stage attrition: Predicting hepatotoxicity in the clinic from early preclinical screening data

Rod Cole
Associate Director, Drug Metabolism and Pharmacokinetics, Abbott Bioresearch Center
Bioanalytical technologies for early DMPK discovery support: Practical considerations and applications


Norman Huebert
Team Leader & Research Fellow ADME, Johnson & Johnson
Research strategies in LG and LO: Combining in vitro and in vivo ADME approaches

Bernard Murray
Senior Research Scientist I, Gilead
Targeted solutions to DMPK problems: Avoiding unnecessary screening

Peng Hsiao
Research Assistant, Jashvant D Unadkat Lab, University of Washington
P-gp based drug interactions at the blood- brain barrier: Fact or fantasy?

Simon Thomas
Head of Scientific Computing, Cyprotex Discovery
Physiologically based pharmacokinetic/pharmacodynamic modelling for lead optimisation of CNS-Active therapeutics

Katya Tsaioun
Chief Scientific Officer, Cyprotex Discovery
New technologies for mechanistic toxicology in lead de-risking: Cellumen's Cellular Systems Biology (CBS™) approach

[buywell2] 02/9/2010 09:57

I wonder if this was an idea from our new head of marketing ?


Cyprotex offers researchers free online access to data




01 September 2010 @ 08:07 am BSTNext Markets Article
Cyprotex is giving researchers free online access to its database of the ADME and pharmacokinetic properties of marketed drugs via its online Cloe Knowledge data visualisation and interpretation tool.


Free access is available via Cyprotex's Cloe Gateway online portal: www.cloegateway.com.

Chief executive Dr Anthony Baxter said: "Cyprotex believes in sharing its knowledge with the scientific community.

"Our CloeKnowledge database of marketed drugs has been compiled and continuously updated based on extensive literature values and data generated in our own laboratories.

"Although some of the data are already available in the public domain, often they have not been conveniently compiled, and certainly not accessible through a powerful visualisation and interpretation tool such as the one Cloe Knowledge provides.

"We believe that free access to these data via Cloe Knowledge will help advance drug discovery, especially within the resource-constrained academic community."

[husbod] 01/9/2010 09:05

Cheers buywell - forgive me but I think I was only stating the blindingly obvious!

[tolrem2] 01/9/2010 08:51

News

September 1, 2010 - Cyprotex provides free online access to Cloe® Knowledge

Cyprotex PLC ("Cyprotex" or "the Company")

Cyprotex Announces Free Access to Physicochemical, ADME, and Pharmacokinetic Data of Marketed Drugs Through Its Visualisation Tool, Cloe® Knowledge

Cyprotex PLC (LSE:CRX), the preclinical ADME Tox services company, today announces that it is making available to researchers free online access to Cyprotex's database of the ADME and pharmacokinetic properties of marketed drugs via its online Cloe® Knowledge data visualisation and interpretation tool.

Free access is available via Cyprotex's Cloe® Gateway online portal: www.cloegateway.com.

Cloe® Knowledge categorises marketed drugs according to the 2009 WHO ATC/DDD drug index, allowing the database to be searchable by therapeutic area. Cloe® Knowledge's compound property visualisation tools allow relationships between different ADME and phys-chem properties to be viewed on either 2D or 3D scatter plots.

Commenting on the announcement, Dr Anthony D Baxter, Cyprotex's Chief Executive Officer, said:

"Cyprotex believes in sharing its knowledge with the scientific community. Our Cloe® Knowledge database of marketed drugs has been compiled and continuously updated based on extensive literature values and data generated in our own laboratories. Although some of the data are already available in the public domain, often they have not been conveniently compiled, and certainly not accessible through a powerful visualisation and interpretation tool such as the one Cloe® Knowledge provides. We believe that free access to these data via Cloe® Knowledge will help advance drug discovery, especially within the resource-constrained academic community."

Enquiries:

Cyprotex PLC
Dr Anthony Baxter, Chief Executive Officer
John Dootson, Chief Financial Officer
Mark Warburton, Chief Operating Officer and Legal Counsel
Tel: [phone]
[e-mail]
www.cyprotex.com

Singer Capital Markets Limited (broker to Cyprotex)
Tel: [phone]
Shaun Dobson
[e-mail]
Claes Spang
[e-mail]
www.singerscm.com

Financial Dynamics
Ben Brewerton
Ben Atwell
Mo Noonan
Tel: [phone]
[e-mail]
www.fd.com

[buywell2] 01/9/2010 08:20

Some USA investors might be buying CRX shares

However I think if there were 'investors' button/links added to both the cellumen and apredica websites then with circa 100's of visitors to those sites per day , I think more USA investors would be buying Cyprotex shares.

The 'investors' button , could be just like that on the Cyprotex website , in fact it could hold the same data cache.

Just a thought ...

[buywell2] 01/9/2010 08:15

Good call Husbod ........ 8.5/10 for you


Husbod - 18 Aug'10 - 09:02 - 1728 of 1809


Just the news I wanted. Was going to post yesterday that it was time we had some director's buys given the "transformational" nature of the deal. Have topped up on the strength of these two factors and think it might be difficult to buy under 5p pretty soon.

[moosh2] 31/8/2010 08:24

8p here we comes! la la la la...

[spekky] 30/8/2010 18:31

On a bit of a road trip next few days (Leeds to Lyon) so unable to keep an eye on the action,however,on my return I fully expect the share price to be a little ahead of where it is at present........fingers crossed.

[cotton4] 29/8/2010 09:28

IMO this is the start of something quite exciting at CRX.
We have a company which has just issued shares at 3.5p which are now trading at 5.5p in just a short period of time. Profits for the half year came in at some £50k and the company it has acquired, Apredica has profits of £100k for the whole year. So an a simple PE basis the company is over valued, but that is too crude a picture of what is happening here.

This is about future earnings, market sentinment and the amount of shares available for small investors.

Future earnings is probably going to be the biggest driver of the share price here and I have written at length re this matter. Given that both companies (CRX and Apredica, and not to mention any earnings from Cellumen IP) have now effectively doubled their customer base the potential for cross selling of products is huge. Obviously only the last quarter of 2010 will benefit in part to this, but 2011 will be very interesting. Dearlt love to get a copy of the brokers note, which is immentent.

Market sentiment has also changed over the last few weeks. The amount of trades being done on a daily basis has increased significantly indicating more interest in this stock than there has been for some years. Coupled with the scale of director buys, this is now very much on the radar of a lot more investors. The "problem" for new investors is that htere are not a lot of short term shares available,IMO. If you strip out institutional holdings and director holdings you are left with less than 40% of the share capital available for shareholders with a < than 3% holding or 80Million shares or there about. We already have several posters here who own at least a million and others with several hundred thousand (self included)so it will not take many to gather up these 80m shares.

With regard to this BB, what I also find conforting is that there are no apparent rampers, perhaps from Buywell and myself, who have always probably been over optimistic. However there has been no real evidence of the "ramp" brigades that are seen on other BB's.

Press coverage will only add to more potential investors and a copy of the Daily Mail article would be welcome. But this will only add to even more interest in the company and probably more people wanting a stake its in future.

IMO I think you will find that the share price has only started to move and as new products and developments unfold over the coming months, any announcements will only add to the upward momemtum. Where the share price will be in 12 months is anybodies guess but I have never been so positive re the outcome of any other stock.

This is not meant as a ramp as with any stocks there are risks and with a gross profit in the region of 85% any drop in sales will have a material effect on the bottom line. I would dearly like to see the share price fall, where I can top up but I may have to patient until some day traders take profits, but the feeling is that this is not going to happen in the near future.

I also believe that the directors move in buying shares makes the possibility of a take-over approach less likely. Well I hope so, but any predator will now have to pay substially more for these now. Just Sunday morning thoughts. GLA.

[redprince] 28/8/2010 19:30

Spekky - saw that and twas a fairly big space too.Nice chart and the director buys splashed all over it.

[spekky] 27/8/2010 17:04

I was thinking the same or maybe its been tipped somewhere (again).It also occurs to me that there may now be additional interest from across the pond from some admirers of Apredicas work.It will be interesting to see if all future RNSs will have a PRNUS (as per the last one).

[cotton4] 27/8/2010 16:20

The only thing I can think of that is due is the brokers report for thoses who have access to it.

[cotton4] 27/8/2010 16:14

Tried to buy another 20k online - to no avail - deal now done.

[6tangler9] 27/8/2010 16:04

And a few Trades on plus..

[moosh2] 27/8/2010 15:39

then someone paid less and it went up lol.