Angle Share Discussion Threads

[bones699] 23/3/2024 22:51

Adw198

Go on impress me how many Parsortix machines have been sold to date?

[bones699] 23/3/2024 17:40

My nemesis fake Bones698 claimed he sold half his holding when the share price topped 40p on 4th January recently having been invested for a very long time yet didn't do similar when the share price touched 140p on 22nd May 2022...which tells me he never sold a single share, what a total liar, hence fake Bones698 spreading more lies!

[bones699] 23/3/2024 17:35

Yup let's delude ourselves and keep posting test trials, assays, demos, trade shows and never discuss why no one is actually buying any Parsortix machines?

Funny at the recent Investor Meeting there were no slides on the product pipeline and expected sales volumes of Parsortix this year, wonder why?

How do we justify £6.6m revenues this year in order to support the Q2 2025 cash runway if we have no idea where they are likely to come from!

[gooosed] 23/3/2024 16:00

Bermudashorts - an excellent post & a sobering reminder of what is really at stake in the field of oncology & with this innovative British MedTech Company.

Messrs. Ciccioli & Young will also present their posters at the American Association of Cancer Research (AACR) in a little over two weeks time.

The floor map shows the close proximity of Pfizer Oncology, Merck, Eli Lilly & Novartis. The other "household names" such as Astrazeneca, Johnson & Johnson, Bristol Myers Squibb, Genentech, Amgen, Daiichi Sankyo & Moderna etc. are all attending.

[adw198] 23/3/2024 15:01

I agree they’ll try not to raise. Just like they’ll try to get £6.6m of revenue this year. In business you don’t always get what you want - as the last 2 trading updates showed. Doesn’t mean there’s not a business here - I really think there is, I just wish we had another 12months up our sleeves

[adw198] 23/3/2024 13:39

@bonesy the answer he gave was actually directly in response to whether a further raise would be needed. 23m 40s in. I personally think one will be. I can be honest here because I wasn’t sacked from the company for being an obsessive bitter c@unt.



With a z on the end

[pj84] 23/3/2024 13:16

Adw198 best to filter as bones699 is just continuing his never ending spat with bones698 from Nanoco.

[bones699] 23/3/2024 13:00

Havinthelasttoast

Think your right I smell fear rising here!

Newland did infer at the January investor meet that one strategic option was a cash placing as they had done it before yet none of the gerbils asked if that was unlikely, gullible novices ready for the chop!

[havinthelasttoast] 23/3/2024 10:27

Yes bonés there was some leak here last week.

Some posted tried to say an email from AN denied it lol but we can take that with a pinch of salt. Rampers say anything.

[bones699] 23/3/2024 10:00

Did someone say placing probably sub 12p must be round the corner?

How much cash is left 🤔 in the kitty?

[pj84] 22/3/2024 23:19

This is the direct link to the HER2 presentation

and this is the direct link to the presentation on comprehensive Circulating Tumour Cell Analysis

Both courtesy of Bermudashorts link above.

[pj84] 22/3/2024 21:23

Bermudashorts thanks as ever, as I suspect like a lot of holders I would have missed those publications on the Angle website and for your helpful interpretation of the significance of the change of HER2 status in that small group who sadly passed away within 4 months of that latest blood draw. Whilst the information is clearly there in the presentation, it could easily be missed in amongst all the other information in the presentation without you highlighting it above.

Like a lot of holders I had thought the the FDA approval in MBC would quickly lead to sales and that we would be bought out by the likes of Abbot or another big player before we got to see the full potential of Parsortix and whilst it has been a slow and painful journey for holders, it finally feels that the initial promise is getting closer. I hope that someone will soon be testing if giving some of the treatments for HER2 positive patients to patients who weren't initially HER2 positive yields positive results.

[bobbie121] 22/3/2024 21:11

Bermuda, if I wasn’t so busy in my own business, I would love to become a salesperson for angle, if you have any time on your hands, perhaps you could apply for a part-time job and sell the business worldwide. seriously.

[bermudashorts] 22/3/2024 17:49

gooosed thanks for that. The posters are now on Angle's website and worth a read for any longs here. The HER2 poster was interesting and this line sums up the potential of CTC liquid biopsies:-

'Notably, five donors from Group 2 (tissue HER2-negative) passed away within 4 months of presenting clusters of Epithelial CTCs in a blood draw. Of these five donors, three presented clusters of Epithelial HER2+ CTCs'

So these were patients who had a traditional tissue biopsy at outset which showed their primary tumour was HER2 negative and they were treated accordingly. However somewhere along the line they started shedding HER2 positive circuating tumour cells which demonstrates how cancer can evolve. We'll never know whether those patients may have benefited from a switch to one of the HER2 therapies or how many other women are in the same position right now. It highlights perfectly the limitations of relying on tissue biopsy taken months or years previouisly and the value of a liquid biopsy that can monitor HER2 expression in real time and flag patients who may be suitable for HER2 targeted treatment.

[havinthelasttoast] 22/3/2024 17:11

How did you see it if I was filtered hahahahah

That old filter chestnut. Got to larf at you plebs

[havinthelasttoast] 22/3/2024 16:28

Sorry to hear about the news boys and that RNS late on

[adw198] 22/3/2024 16:25

Nobody has seen an email saying there’s not going to be a raise. People have seen a reply from AN to a question that wasn’t shared, so we don’t know exactly what was asked / the context of his answer.

[havinthelasttoast] 22/3/2024 15:53

Very suspicious then.

Can you post the email.