Angle Share Discussion Threads

[bagpuss67] 06/3/2024 07:39

This year will we finally see the huge investment in the FDA giving some material payback.

[radderssandy] 06/3/2024 07:37

A couple of other mentions of Parsortix as well at the AACR.

[bones699] 06/3/2024 07:34

Can someone pls remind me of the date for the next cash placement?

[bermudashorts] 06/3/2024 07:33

It seems that progress has been made with the Angle/BioView collaboration on the HER2 assay. They are presenting a joint poster at AACR in April which details prgress. Title as follows:-

'3705 / 17 - Development and analytical validation of a novel assay for HER2 assessment on circulating tumor cells using Parsortix® isolation and BioView imaging technologies'

From the conclusion:-

' An assay integrating HER2 identification by IF and FISH to characterize CTCs in metastatic BC patients was successfully developed. The assay enables the identification of both HER2 protein and gene copy information from each target cell with minimal cell loss, with the potential for minimally invasive patient monitoring during treatment and better classification of patients who may qualify and benefit from HER2-targeted therapies. An added value of the assay is the practicality of utilizing preserved blood samples, allowing streamline batch shipping of clinical samples'

[bagpuss67] 05/3/2024 16:18

Phew. What a relief...

[atmysignal] 05/3/2024 11:51

Rns soon. I can feel it in my bones.

[bones699] 04/3/2024 19:27

I entirely agree with the following comments!

bones699

4 Mar '24 - 16:23 - 23360 of 23361

"Bones698 is just bitter and twisted because he got shafted on nano and then missed the spike here even though he was told. You can't educate stupid and now spends hours every week trying to make himself look important even though he has no clue what he's doing. Sad little troll I find hilarious I got under his skin so much he now wastes so much time. Must have a very sad and lonely life"

[muffster] 04/3/2024 16:40

You mean Bones699?

[bones698] 04/3/2024 16:23

Bones699 is just bitter and twisted because he got shafted on nano and then missed the spike here even though he was told. You can't educate stupid and now spends hours every week trying to make himself look important even though he has no clue what he's doing. Sad little troll I find hilarious I got under his skin so much he now wastes so much time. Must have a very sad and lonely life

[bones699] 04/3/2024 12:04

Down already over 5% as expected!

[adw198] 04/3/2024 08:14

Hey Bones699, if you’re so smart perhaps you explain what you’re doing here (and LSE)? Are you still pretending to be an investor and if so please explain why given you think fair value is 4p. Might be a good time to sell!

[bones699] 04/3/2024 07:20

Good Morning Loser do you have your red flags at hand?

[zeus19] 04/3/2024 06:15

Another Friday night spent on the bulletin boards you sad git

[bones699] 03/3/2024 12:37

The only thing going feral is that solitary brain cell in your fat head adw198!..😉

[adw198] 03/3/2024 08:32

And to think you post on both boards pretending to be a long term investor, whilst those poor kids of yours go feral. Just because you were sacked :)

[bones699] 01/3/2024 23:01

If the LSE BB is the echoe chamber this one must be the delusional psychosis ward!

[bagpuss67] 01/3/2024 13:03

I think next up its an update on Bioview and next steps - hopefully a partner coming on board..

[fhmktg] 01/3/2024 12:48

The team will be saying goodbye to San Diego as we sleep tonight...let's hope they have good news to bring home!
Time for the updates on Ovarian and Prostate projects....

[boris cobaka] 01/3/2024 11:21

Perhaps a buyout with a Royalty agreement. In addition is there a partial sale element with other avenues for agl to research and develop??

[gooosed] 01/3/2024 10:00

PDT - unfortunately history is on your side but that is merely my own preference. It'll take one or maybe a couple of "household name" contracts to significantly elevate Angles profile.
What happens from there will be determined by the ongoing advances in CTC harvesting etc (T cell analysis which was briefly touched upon, in the AJ Bell presentation) but I agree Angle are in a race to develop content.
They do though have a number of runners in the race - Solaris Healthcare/MidLantic with 900,000 patients is just one.
I suspect we have a Unicorn in the making but let's see what happens.

[pdt] 01/3/2024 09:47

gooosed - agreed. However, the liquid biopsy space is growing very quickly now. There are large multinationals with billions invested and billions in revenue from cancer drugs that can treat the variants Parsortix is picking up. There are billion cap diagnostic companies already competing for business and will need a solution quickly in the the ctcDNA space.

Angle will not have time to grow into a large company which means it will very likely be swallowed up.

[gooosed] 01/3/2024 09:28

PDT - Newland has said previously that Angle will either become a large company or will be acquired by a large company. Obviously no hints from him at timeframes but it is my sincere hope that Angle are able to remain independent & grow. Too many UK companies are bought out & we need (imho - now more than ever) to develop our successful tech companies.

[pdt] 01/3/2024 09:17

Thanks for highlighting the Sciencedirect paper which was written before the release of Angle's latest news in January.

There doesn't seem to be a preferred method for CTC capture and all those mentioned seem to have disadvantages of one form or another. CellSearch and Parsortix appear to be leaders. The former was mentioned in an Angle authored paper to miss a range of CTCs and this paper says that Parsortix may not pick up small CTCs such as can occur in Prostate cancer. However, both have a nod from the FDA.

CellSearch is owned by Menarini (17,000 employee company). The market size for ctDNA analysis is expected to rise from $2 billion to $8 billion in the next few years and ctcDNA analysis looks likely to capture a good share of that based on recent news.

My feeling is that Angle will not be independent 2 years from now.

[muffster] 29/2/2024 23:21

More waffle....hello chief waffler.Brain lacking bones speaks again.

[bones699] 29/2/2024 22:19

More waffle here no substance just more demos leading nowhere and as yet no commercial deals..Not really surprising for a product like Parsortix that nobody actually wants or uses!