Advanced Oncotherapy Share Discussion Threads

[paul_98] 07/11/2017 20:55

Then we can look forwards to completion etc.

[andy] 07/11/2017 20:35

I expect to hear that they have raised money via a placing or other source of funds, before Christmas.

[paul_98] 07/11/2017 19:34

Do you think we'll hear anything this side of Christmas?

[paul_98] 06/11/2017 12:45

No reason to not believe. IMO. It's been holding steady for a while now so a steady ship awaiting the sail!!

[andy] 06/11/2017 00:35

shlky,

I suspect a placing is going on now, the sideways movement at 20% above looks like it, IMO.

[shakyhands] 05/11/2017 22:22

With the share price where it is now,my guess is they'd only get investors who believe in the story interested in a placing at 25p.There wouldn't be enough in it for flippers.

[daijavu] 05/11/2017 20:10

There will be no competition between Harley Street and UCHL. UCLH will cater mainly for NHS patients whereas Harley Street will cater mainly for private patients many of whom will come from abroad, although it is possible that the NHS will be able to buy time in the Harley Street Clinic. AVO have said that Harley Street will also devote a number of hours a week to the free treatment of children and have said that all their contracts will require the operators of LIGHT to devote time each week for the free treatment of children regardless of whether the clinics or hospitals concerned are in the private or public sector.

[paul_98] 05/11/2017 19:45

No idea but I wish we would find out soon!

[andy] 05/11/2017 18:47

paul,

Do you think they are undertaking a placing or other financing at the moment?

[paul_98] 05/11/2017 16:46

I see no harm in more proton beam therapy. Good for people and makes it a hot topic.

[andy] 05/11/2017 11:28

I see the price tracking sideways at 20% above the minimum placing price.


I wonder if a 25p book build is gong on?

[wi1l] 05/11/2017 11:22

Any proton treatment has to be performed abroad atm, hence the need and interest in AVO. This will be competition right on their doorstep and may be first point of call for treatment with AVO taking up the remainder. Rather than have all the market share they will only have a % of it.

[paul_98] 05/11/2017 10:44

Has there not always been NHS/Private sectors running successfully at the same time? Dentists, doctors etc. It's no issue or competition, totally different market.

[wi1l] 05/11/2017 10:38

seems it will be right on your doorstep.
The UCLH service will be delivered from the Trust’s campus in the heart of the capital where it enjoys a close collaboration with UCL on groundbreaking research projects. The site has direct access to the Trust’s existing radiotherapy department and will be a stone’s throw from the new University College Hospital Macmilan Cancer Centre which opened only this week (April 2). The proposal was developed with the support of the UCLH Charity.

[paul_98] 04/11/2017 23:20

htTTs://www.st-arch.co.uk/project/harley-street-proton-beam-therapy

[paul_98] 04/11/2017 17:47

Room for more than one company I believe. We have Harley Street for a start!! No worries.

[marvin66] 04/11/2017 17:34

Not this again..

[sweet karolina] 04/11/2017 17:06

Wi1l,

Who are UCLH buying their machine from? Not AVO clearly. What capability will the machine have? How much is it costing?

Clearly AVO have a direct competitor who have at least 1 confirmed order.

[wi1l] 04/11/2017 16:28

They seem to be really up against it. The UCLH are building a new proton beam therapy unit close by and anticipated to commence 2020. How will that affect this project ?? Looks like it is now a bit of a race to get going first - competition with the NHS, who will win that one??!!

[paul_98] 03/11/2017 10:42

I've emailed the company asking for any sort of clarification or news but no reply.

[paul_98] 02/11/2017 08:41

Very well put. Another thing that will generate interest will be news coverage of the Harley Street installation. It's such a flagship centre and will be a big deal for potential investors.

[glibgibon] 02/11/2017 00:49

There was a quiet spell on the LSE board just over a month ago so I posted an overview of my opinion on the company. Sorry for the copy-pasta but it may be of interest. With regards the testing, they are pretty much at the beginning of the combined component test with the beam going through the SCDTL - their presentation should have a timeline of what is expected.

I'm no longer invested here but keeping an eye on this share. As no one else is speaking to Ian, I'll give my tuppence worth. Fixing the long term financing will be important, but that will not make them a viable business. There are plenty of businesses going nowhere that have financial support. For me, it will be all about the product and when they get regulatory approval. We have been told that the individual components have been tested but we need confirmation that the finished product will deliver.

I believe that the transformational news will be the confirmation that the accelerators can create a beam energy of 230MeV. We have been informed that the RFQ has successfully accelerated the proton beam from 4keV to 5MeV. Also all the CCL modules have been delivered to Geneva for testing now. The SCDTL has been tested at high power but it is not clear exactly what level was used - I do not think we have had confirmation that the beam can be accelerated to 20-25MeV yet.

The beam will go from the proton source, through the RFQ and then through the SCDTL. We are close to that stage I believe but the beam is expected to be fired through the first CCL at the end of Q2 2018. As the system is modular then sales may begin at this stage but I believe multiple CCL modules must be shown to work to provide proof that companies can buy the system and upgrade as funding becomes available - otherwise only superficial tumors can be treated and other products may be seen as either more desirable or they meet the demand for stronger therapies. It is also unclear if a machine will be available for clinical tests and regulatory compliance checks. If not then it may be that orders are made in the same way Sinophi did, but any money would not be available for use and would need to be ring fenced.

After 3 CCL modules the beam should be 70MeV. After 6 it will be 150MeV and with all 10 the beam strength should be the 230MeV target. The various confirmations of the CCL modules meeting the expected speeds should make the product more appealing and sales will undoubtedly be generated from this as more units and additional CCL modules can be sold based on individual requirements.

I think after the 50-70MeV level is reached then the company may be secure if it is generating enough income to fund the further testing and research required. If all goes well then perhaps by 2021 if the regulatory bodies give the all clear. Money will remain a long term issue if they do not intend to seek regulatory approval for the weaker units. Waiting until the 230MeV target is met will probably mean at least another full year without income which could seriously jeopardise cashflow, finance and sentiment.

[glibgibon] 02/11/2017 00:39

Individual components have been tested before. They have never been put together which is why testing is ongoing.

Part of the monetisation will be from selling the machines (approx £15m each + maintenance) but they will also be part owners of the treatment facility. You'd need to read through some of the RNS' and financial reports for specifics.

I am no longer invested as they do not have long term financing in place, but as existing machines are based on CERN technology and this is new CERN technology that is getting developed, it is definitely one to watch if they get it right.

[andrewsr] 01/11/2017 18:50

It looks very promising, I'll keep a close watch on it. Good luck.

[paul_98] 01/11/2017 12:39

IMO it's an exciting share to hold. Nobody quite knows the full picture, saying that it's obvious there were stumbling blocks early on in the project that we've been assured are now on track. I'm very happy to sit on what I have in AVO and patiently wait. Some do knock it but plenty support it too.