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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| RTW Investments, LP | Institution | 6,574,032 | 5.85% | US$ 108.34M | 2026-03-31 |
| FMR LLC | Institution | 6,371,550 | 5.67% | US$ 105.00M | 2026-05-27 |
| Baillie Gifford & Co. | Institution | 5,916,167 | 5.27% | US$ 97.50M | 2025-12-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 5,740,762 | 5.11% | US$ 94.61M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 5,707,262 | 5.08% | US$ 94.06M | 2026-03-31 |
| Qiming Weichuang Venture Capital Management (Shanghai) Company Limited | Institution | 4,888,364 | 4.35% | US$ 80.56M | 2025-12-31 |
| Qiming Venture Partners Iv, L.P. | Institution | 4,738,741 | 4.22% | US$ 78.09M | 2025-12-31 |
| Norges Bank Investment Management | Institution | 3,868,017 | 3.44% | US$ 63.74M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 3,247,595 | 2.89% | US$ 53.52M | 2026-04-30 |
| Wellington Management Group LLP | Institution | 3,092,804 | 2.75% | US$ 50.97M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2,802,881 | 2.49% | US$ 46.19M | 2026-04-30 |
| The Goldman Sachs Group, Inc. | Institution | 2,547,121 | 2.27% | US$ 41.98M | 2026-05-21 |
| Frazier Life Sciences Management, LP | Institution | 1,902,320 | 1.69% | US$ 31.35M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1,688,632 | 1.50% | US$ 27.83M | 2026-03-31 |
| Baron Capital Group, Inc. | Institution | 1,658,318 | 1.48% | US$ 27.33M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1,425,367 | 1.27% | US$ 23.49M | 2026-03-31 |
| Dr. Ying Du | Insider | 1,158,583 | 1.03% | US$ 19.09M | 2026-05-27 |
| China Universal Asset Management Company Ltd. | Institution | 1,045,395 | 0.93% | US$ 17.23M | 2026-03-31 |
| UBS Asset Management AG | Institution | 963,647 | 0.86% | US$ 15.88M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 880,173 | 0.78% | US$ 14.51M | 2026-04-30 |
| Bosera Asset Management Co., Ltd. | Institution | 853,520 | 0.76% | US$ 14.07M | 2025-06-30 |
| Rock Springs Capital Management LP | Institution | 814,707 | 0.73% | US$ 13.43M | 2026-03-31 |
| China Asset Management Co. Ltd. | Institution | 798,781 | 0.71% | US$ 13.16M | 2026-04-30 |
| GF Fund Management Co., Ltd. | Institution | 696,193 | 0.62% | US$ 11.47M | 2026-03-31 |
| Invesco Great Wall Fund Management Co. Ltd | Institution | 625,440 | 0.56% | US$ 10.31M | 2025-12-31 |
| Schroder Investment Management Limited | Institution | 575,080 | 0.51% | US$ 9.48M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 531,479 | 0.47% | US$ 8.76M | 2026-04-30 |
| ICBC Credit Suisse Fund Management Co., Ltd | Institution | 519,970 | 0.46% | US$ 8.57M | 2025-06-30 |
| C WorldWide Asset Management Fondsmaeglerselskab A/S | Institution | 510,000 | 0.45% | US$ 8.40M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 468,250 | 0.42% | US$ 7.72M | 2025-09-30 |
| Dimensional Fund Advisors LP | Institution | 458,360 | 0.41% | US$ 7.55M | 2026-04-30 |
| The B Group, Inc. | Institution | 450,646 | 0.40% | US$ 7.43M | 2026-03-31 |
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