Vertex to Announce First Quarter 2014 Financial Results on May 1

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) will report its first quarter 2014 financial results on Thursday, May 1, 2014 after the financial markets close. The company will host a conference call and webcast at 5:00 p.m. ET. To access the call, please dial [phone] (U.S.) or [phone] (International).

The conference call will be webcast live and a link to the webcast may be accessed through Vertex's website at www.vrtx.com in the "Investors" section under "Events and Presentations.” To ensure a timely connection, it is recommended that users register at least 15 minutes prior to the scheduled webcast. An archived webcast will be available on the company's website until June 30, 2014.

About Vertex

Vertex is a global biotechnology company that aims to discover, develop and commercialize innovative medicines so people with serious diseases can lead better lives. Vertex scientists and our collaborators are working on new medicines to cure or significantly advance the treatment of cystic fibrosis, hepatitis C, rheumatoid arthritis and other life-threatening diseases. In addition to our clinical development programs, Vertex has more than a dozen ongoing preclinical programs aimed at other serious and life-threatening diseases.

Founded in 1989 in Cambridge, Mass., Vertex today has research and development sites and commercial offices in the United States, Europe, Canada and Australia. For four years in a row, Science magazine has named Vertex one of its Top Employers in the life sciences. For additional information and the latest updates from the company, please visit www.vrtx.com.

(VRTX-WEB)

Vertex Pharmaceuticals IncorporatedInvestors:Michael Partridge, 617-341-6108orKelly Lewis, 617-961-7530