Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Sachdev Amit	2. Issuer Name and Ticker or Trading Symbol VERTEX PHARMACEUTICALS INC / MA [ VRTX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                      _____ 10% Owner __ X __ Officer (give title below)      _____ Other (specify below) EVP, CRO
(Last)          (First)          (Middle) C/O VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE	3. Date of Earliest Transaction (MM/DD/YYYY) 2/5/2018
(Street) BOSTON, MA 02210 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	2/5/2018		M		1942	A	$86.52	41105	D
Common Stock	2/5/2018		M		2578	A	$77.31	43683	D
Common Stock	2/5/2018		S (1)		378	D	$158.55   (2) (3)	43305	D
Common Stock	2/5/2018		S (1)		700	D	$159.93   (3) (4)	42605	D
Common Stock	2/5/2018		S (1)		300	D	$160.97   (3) (5)	42305	D
Common Stock	2/5/2018		S (1)		300	D	$161.93   (3) (6)	42005	D
Common Stock	2/5/2018		S (1)		600	D	$163.79   (3) (7)	41405	D
Common Stock	2/5/2018		S (1)		2242	D	$164.93   (3) (8)	39163	D
Common Stock								882	I	401(k)
Common Stock								12215	I	Held in Trust

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$86.52	2/5/2018		M			1942	(9)	2/2/2027	Common Stock	1942	$0.00	23299	D
Stock Option (Right to Buy)	$77.31	2/5/2018		M			2578	(10)	2/4/2024	Common Stock	2578	$0.00	0	D

Explanation of Responses:
(1)	Transaction made pursuant to Mr. Sachdev's company-approved trading plan under Rule 10b5-1.
(2)	Open market sales reported on this line occurred at a weighted average price of $158.55 (range $158.24 to $159.09).
(3)	Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price.
(4)	Open market sales reported on this line occurred at a weighted average price of $159.93 (range $159.46 to $160.47).
(5)	Open market sales reported on this line occurred at a weighted average price of $160.97 (range $160.51 to $161.26).
(6)	Open market sales reported on this line occurred at a weighted average price of $161.93 (range $161.70 to $162.39).
(7)	Open market sales reported on this line occurred at a weighted average price of $163.79 (range $163.23 to $164.22).
(8)	Open market sales reported on this line occurred at a weighted average price of $164.93 (range $164.31 to $165.06).
(9)	The option vests in 16 quarterly installments from 2/3/2017.
(10)	Fully vested.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Sachdev Amit C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON, MA 02210			EVP, CRO

Signatures
/s/ Omar White, Attorney-in-Fact		2/7/2018
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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