Revolution Medicines to Deliver Multiple Presentations at the Upcoming American Association for Cancer Research Annual Meeting 2024

Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage oncology company developing targeted therapies for patients with RAS-addicted cancers, today announced the company will deliver multiple presentations at the upcoming American Association for Cancer Research (AACR) Annual Meeting 2024 being held April 5-10, 2024, in San Diego, California.

Details of the planned presentations are listed below:

Revolution Medicines Oral Presentations:

Title:	Discovery of RMC-9805, an Oral, RAS(ON) G12D-Selective Covalent Tri-Complex Inhibitor
Presenter:	John Knox, Ph.D.
Abstract Number:	ND03
Session:	New Drugs on the Horizon: Part 1
Date/Time:	1:45 – 2:00 p.m. PT on April 7, 2024
Title:	RMC-6236, a RAS(ON) Multi-Selective Tri-Complex Inhibitor
Presenter:	Elena Koltun, Ph.D., Wei Lin, M.D.
Session:	KRAS: Broadening the Attack Beyond G12C with Small Molecules and Immuno-Oncology
Date/Time:	1:00 – 1:20 p.m. PT on April 9, 2024
Title:	Combination of RAS(ON) G12C-Selective and Multi-Selective Tri-Complex Inhibitors Overcomes Resistance and Prolongs Durability in Preclinical Models of KRASG12C NSCLC
Presenter:	Xing Wei, Ph.D.
Abstract Number:	6585
Session:	Novel Antitumor Agents 5
Date/Time:	2:35 – 2:50 p.m. PT on April 9, 2024

Revolution Medicines Poster Presentations:

Title:	Potential Biomarkers of Response to the Combination of the RAS(ON) Multi-Selective Inhibitor RMC-6236 Plus Anti-PD-1 Antibody in Preclinical PDAC Models
Presenter:	Lillian Seu, Ph.D.
Abstract Number:	581/4
Session:	Immunotherapy
Date/Time:	1:30 – 5:00 p.m. PT on April 7, 2024
Title:	RMC-5127, a First-in-Class, Orally Bioavailable RAS(ON) G12V-Selective Tri-Complex Inhibitor, is CNS-Penetrant and Drives Regressions in Intracranially Implanted KRASG12V Xenograft Tumors
Presenter:	Zhe Chen, M.B.B.S., Ph.D.
Abstract Number:	3340/28
Session:	Novel Antitumor Agents 3
Date/Time:	1:30 – 5:00 p.m. PT on April 8, 2024
Title:	The RAS(ON) Multi-Selective Inhibitor RMC-7977 Blocks Downstream MAPK and PI3K Pathway Activation in KRASG12X-Mutant Cancers
Presenter:	Priyanka Bapat, Ph.D.
Abstract Number:	4709/2
Session:	Other Cellular Mechanisms for Anticancer Drug Action
Date/Time:	9:00 a.m. – 12:30 p.m. PT on April 9, 2024

Collaborator Poster Presentations:

Title:	RTK Signaling and WT RAS Activity as Vulnerabilities in Tumors with Acquired Resistance to GDP-State Selective KRASG12C Inhibitors in Preclinical Models
Lead RevMed Co-Author:	Harshit Shah, Ph.D.
Abstract Number:	1924/2
Session:	Drug Resistance 2: RAS GTPase
Date/Time:	9:00 a.m. – 12:30 p.m. PT on April 8, 2024
Title:	Resistance to RAS-GTP Inhibition in Models of Pancreatic Ductal Adenocarcinoma Arises Downstream of RAS Effectors
Lead RevMed Co-Author:	Jingjing Jiang, Ph.D.
Abstract Number:	1927/5
Session:	Drug Resistance 2: RAS GTPase
Date/Time:	9:00 a.m. – 12:30 p.m. PT on April 8, 2024

Additional information on the AACR Annual Meeting 2024 is available through the AACR website at: https://www.aacr.org/meeting/aacr-annual-meeting-2024/

About Revolution Medicines, Inc.Revolution Medicines is a clinical-stage oncology company developing novel targeted therapies for RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS companion inhibitors for use in combination treatment strategies. The company’s RAS(ON) inhibitors RMC-6236, a RAS(ON) multi-selective inhibitor, RMC-6291, a RAS(ON) G12C-selective inhibitor, and RMC-9805, a RAS(ON) G12D-selective inhibitor, are currently in clinical development. Additional RAS(ON) mutant-selective inhibitors in the company’s development pipeline include RMC-5127 (G12V), RMC-0708 (Q61H) and RMC-8839 (G13C).

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