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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Farallon Capital Management, L.L.C. | Institution | 1,227,590 | 6.19% | US$ 32.83M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 1,020,410 | 5.15% | US$ 27.29M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 1,020,410 | 5.15% | US$ 27.29M | 2025-08-11 |
| Commodore Capital Master LP | Institution | 1,000,000 | 5.05% | US$ 26.74M | 2025-08-08 |
| Commodore Capital LP | Institution | 1,000,000 | 5.05% | US$ 26.74M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 865,251 | 4.37% | US$ 23.14M | 2026-05-04 |
| Janus Henderson Group plc | Institution | 849,309 | 4.29% | US$ 22.71M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 758,963 | 3.83% | US$ 20.29M | 2026-05-04 |
| Farallon Capital Offshore Investors II, L.P | Institution | 497,192 | 2.51% | US$ 13.29M | 2025-12-31 |
| Parkman Healthcare Partners LLC | Institution | 411,227 | 2.08% | US$ 11.00M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 344,105 | 1.74% | US$ 9.20M | 2026-03-31 |
| Armistice Capital Master Fund Ltd. | Institution | 316,084 | 1.59% | US$ 8.45M | 2024-12-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 296,855 | 1.50% | US$ 7.94M | 2026-03-31 |
| Farallon Capital Partners, L.P. | Institution | 239,462 | 1.21% | US$ 6.40M | 2025-12-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 224,245 | 1.13% | US$ 6.00M | 2025-12-31 |
| BlackRock, Inc. | Institution | 202,743 | 1.02% | US$ 5.42M | 2026-03-31 |
| StemPoint Capital LP | Institution | 185,435 | 0.94% | US$ 4.96M | 2026-03-31 |
| The B Group, Inc. | Institution | 175,706 | 0.89% | US$ 4.70M | 2026-03-31 |
| Marshall Wace LLP | Institution | 163,400 | 0.82% | US$ 4.37M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 136,315 | 0.69% | US$ 3.65M | 2026-03-31 |
| Schonfeld Strategic Advisors LLC | Institution | 120,500 | 0.61% | US$ 3.22M | 2026-03-31 |
| Caption Management, LLC | Institution | 81,841 | 0.41% | US$ 2.19M | 2026-03-31 |
| Farallon Capital Institutional Partners II, L.P. | Institution | 75,077 | 0.38% | US$ 2.01M | 2025-12-31 |
| HighVista Strategies LLC | Institution | 74,735 | 0.38% | US$ 2.00M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 69,256 | 0.35% | US$ 1.85M | 2026-03-31 |
| Four Crossings Institutional Partners V, L.P. | Institution | 58,135 | 0.29% | US$ 1.55M | 2025-12-31 |
| Seven Fleet Capital Management LP | Institution | 56,147 | 0.28% | US$ 1.50M | 2026-03-31 |
| Farallon Capital F5 Master I, L.P. | Institution | 51,998 | 0.26% | US$ 1.39M | 2025-12-31 |
| Farallon Capital Institutional Partners III, L.P. | Institution | 48,548 | 0.24% | US$ 1.30M | 2025-12-31 |
| Monimus Capital Management, LP | Institution | 48,390 | 0.24% | US$ 1.29M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 47,049 | 0.24% | US$ 1.26M | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 45,049 | 0.23% | US$ 1.20M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 40,889 | 0.21% | US$ 1.09M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 34,499 | 0.17% | US$ 922.50k | 2026-03-31 |
| Morgan Stanley | Institution | 33,055 | 0.17% | US$ 883.89k | 2026-03-31 |
| Farallon Capital (AM) Investors, L.P. | Institution | 32,933 | 0.17% | US$ 880.63k | 2025-12-31 |
| 683 Capital Management, LLC | Institution | 27,863 | 0.14% | US$ 745.06k | 2026-03-31 |
| Wellington Management Group LLP | Institution | 26,496 | 0.13% | US$ 708.50k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 25,437 | 0.13% | US$ 680.19k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 23,804 | 0.12% | US$ 636.52k | 2026-03-31 |
| Trexquant Investment LP | Institution | 22,741 | 0.11% | US$ 608.09k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 20,550 | 0.10% | US$ 549.51k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 19,947 | 0.10% | US$ 533.38k | 2026-03-31 |
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