Holding(s) in Company

RNS Number:1794U
Alizyme PLC
13 January 2004


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

Alizyme plc


2. Name of shareholder having a major interest

(i) FMR Corp.
    82 Devonshire Street
    Boston, MA 02109

Parent holding company of Fidelity Management & Research Company (FMRCO),
investment manager for US mutual funds.

(ii) Fidelity International Limited (FIL)
     P.O. Box HM 670
     Hamilton HMCX, Bermuda

Parent holding company for various direct and indirect subsidiaries, including
Fidelity Investment Services Ltd. (FISL) investment manager for various non-US
investment companies and institutional clients.

(iii) The notifiable interests also comprise the notifiable interest of:

Mr Edward C. Johnson 3d
82 Devonshire Street
Boston, MA 02109

A principal shareholder of FMR Corp. and Fidelity International Limited.



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Shareholders named in 2 above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Shares Held   Management Company                       Nominee/Registered Name

  1,715,900   Fidelity Management & Research Company   HSBC

  1,783,289   Fidelity Investment Services Ltd.        Chase Manhattan Bank 
                                                       London

  4,915,096   Fidelity International Limited           HSBC Client Holdings 
                                                       Nominee (UK) Limited

    260,800   Fidelity International Limited           Chase Manhattan Bank 
                                                       London

     45,119   Fidelity International Limited           State Street Bank & Trust



5. Number of shares / amount of stock acquired

1,322,434


6. Percentage of issued class

0.92%


7. Number of shares / amount of stock disposed

N/A


8. Percentage of issued class

N/A


9. Class of security

Ordinary Shares of 2p each


10. Date of transaction

Unknown


11. Date company informed

12 January 2004


12. Total holding following this notification

8,720,204


13. Total percentage holding of issued class following this notification

6.04%


14. Any additional information

These notifications of disclosable interests constitute separate notifications
of interest in the shares and are combined solely for the purposes of clarity
and efficiency. Nothing herein should be taken to indicate that FMR Corp. and
its direct and indirect subsidiaries, Fidelity International Limited and its
direct and indirect subsidiaries or Mr Edward C. Johnson 3d act as a group or in
concert in respect of the disclosed interests, or that they are required to
submit these notifications on a joint basis.


15. Name of contact and telephone number for queries

Tim McCarthy

Tel. No. [phone]



16. Name and signature of authorised company official responsible for making
this notification

Tim McCarthy


Date of notification

13 January 2004


The FSA does not give any express or implied warranty as to the accuracy of this
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The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.



                      This information is provided by RNS
            The company news service from the London Stock Exchange

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