Ananda Developments PLC Research Roundup

TIDMANA

Ananda Developments PLC

05 January 2023

ANANDA DEVELOPMENTS PLC

("Ananda" or the "Company")

Ananda is an AQSE-listed medical cannabis company creating UK-based operations to grow and provide carbon zero, consistent, medical cannabis for the UK and international markets.

Medical Cannabis Research Roundup

Issue Fifteen

Summary:

Happy New Year! The last couple of months of 2022 produced several significant papers on the evidence for medical cannabis. The list included a number of papers on cannabis and its constituents (i.e. cannabinoids, terpenes, flavonoids etc) and the mechanisms by which they act illustrating the greater understanding that is being generated in the scientific community with regard to medical cannabis and its mechanisms of action. However, below, we cover a few interesting papers that deal with patient experience with medical cannabis. You will note that while there is a lot of potential shown the call is for more trials with more consistent forms of medical cannabis.

   -- Study finds medical cannabis is beneficial in women with treatment resistant Fibromyalgia . 
 
   -- One of the first studies in Japan on intractable epilepsy and CBD shows effectiveness of CBD for reducing 
      seizures . 
 
   -- Study using Low Doses of CBD plus anti-convulsant shows efficacy. 
 
   -- A US survey of medical cannabis use during perimenopause and post-menopause shows beneficial effects . 

STUDY FINDS MEDICAL CANNABIS IS BENEFICIAL IN WOMEN WITH TREATMENT RESISTANT FIBROMYALGIA

   -- Fibromyalgia is a pain-focused syndrome involving diffuse chronic muscle pain, sleep disturbances, and cognitive 
      and functional impairments. 
 
   -- Fibromyalgia affects approximately 3% of the general population. Women are affected two times more than men. 
 
   -- 30 women diagnosed with fibromyalgia and having exhausted pharmacological treatment were assessed for Quality of 
      Life scores, out of 5, prior to medical cannabis treatment and again after one month. 
 
   -- The General quality of life scores went from an average of 1.47/5.00 to 3.43/5.00, a significant improvement! 
 
   -- Given the small number of participants and the short-term treatment further longer term wider cohort studies are 
      recommended. 

ONE OF THE FIRST STUDIES IN JAPAN ON INTRACTABLE EPILEPSY AND CBD SHOWS EFFECTIVENESS OF CBD FOR REDUCING SEIZURES

   -- Despite very strict cannabis regulations in Japan, some cannabidiol (CBD) products have been legally distributed 
      since 2013 and taken by some patients with epilepsy. 
 
   -- A self-administered questionnaire was sent to 38 patients with intractable epilepsy who were taking CBD 
 
   -- The median CBD intake was 12.0 mg/kg/day NB: Product was CBD isolate. 
 
   -- Fifteen patients (53.6%) reported a decrease in seizure frequency. Moreover, two patients (7.1%) showed complete 
      resolution of seizures. 
 
   -- No significant correlation was found between the patient's diagnosis and seizure type or treatment efficacy. 
 
   -- Conclusions: This is the first cross-sectional study of CBD users in Japan suggesting that CBD may be an 
      effective option for Asian patients with refractory epilepsy, regardless of diagnosis or seizure type. 

STUDY USING LOW DOSES OF CBD PLUS ANTI-CONVULSANT SHOWS EFFICACY

   -- Thirty-four patients were included in the study over 12 months. 
 
   -- A high proportion of patients, 16, concluded the study with a total control of the seizures reaching a 100% 
      improvement, 12 reported >= 75% improvement, 3 >= 50%, and 2 >= 25%; only 1 patient had an improvement of less 
      than 25%. 
 
   -- This is the first Latin American study that demonstrates that long-term CBD added to the usual drugs 
      significantly reduces the frequency, duration, and type of seizures in the different aetiologies of epilepsy, 
      being especially effective on the seizures that are the most incapacitating, improving the quality of life of the 
      individual and their family. 
 
   -- The CBD used by the population in our study was sublingual PhytoCBD Oil at two different doses: (i) 3% CBD oil 
      with 0.02% THC and (ii) 15% CBD oil with 0.02% THC, administered twice a day with an average dose of 1 mg/kg/day, 
      ranging from 0.32 to 2.4 mg/kg/day. 

A US SURVEY OF MEDICAL CANNABIS USE DURING PERIMENOPAUSE AND POST-MENOPAUSE SHOWS BENEFICIAL EFFECTS.

   -- Most participants reported current cannabis use (86.1%) and endorsed using medical cannabis for menopause-related 
      symptoms (78.7%). 
 
   -- The top menopause-related symptoms for medical cannabis use were sleep disturbance (67.4%) and mood/anxiety 
      (46.1%). 
 
   -- Results suggest that many individuals are currently using medical cannabis as an adjunctive treatment for 
      menopause-related symptoms, particularly sleep disturbance and mood/anxiety. 
 
   -- Future research should examine the impact of different MC use characteristics (e.g., cannabinoid profiles) on the 
      efficacy of MC use for menopause-related symptoms. Increased severity and prevalence of mood and anxiety symptoms 
      in perimenopausal participants suggest promising targets for clinical trials of cannabinoid-based therapies. 

-Ends-

The Directors of the Company accept responsibility for the contents of this announcement.

ANANDA DEVELOPMENTS PLC [phone]

Chief Executive Officer

Melissa Sturgess

Investor Relations

Jeremy Sturgess-Smith

PETERHOUSE CAPITAL LIMITED [phone]

Corporate Finance

Mark Anwyl

Corporate Broking

Lucy Williams

Duncan Vasey

About Ananda Developments

Ananda is an AQSE-listed medical cannabis company creating UK-based operations to grow and provide carbon zero, consistent, medical cannabis for the UK and international markets.

For more information, please visit: https://anandadevelopments.com/

This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact [e-mail] or visit www.rns.com.

Reach is a non-regulatory news service. By using this service an issuer is confirming that the information contained within this announcement is of a non-regulatory nature. Reach announcements are identified with an orange label and the word "Reach" in the source column of the News Explorer pages of London Stock Exchange's website so that they are distinguished from the RNS UK regulatory service. Other vendors subscribing for Reach press releases may use a different method to distinguish Reach announcements from UK regulatory news.

RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy.

END

NRABUGDBDDGDGXS

(END) Dow Jones Newswires

January 05, 2023 02:15 ET (07:15 GMT)