Skinbiotherapeutics Share Discussion Threads

[jammyjim] 08/11/2018 18:44

Hydrocortisone is used once-a-day and can be expected to show improvements within 3 to 7 days and then you should continue to use the cream. This does not mean people do not have to wash for the seven days. E45 as well as many other creams can relieve symptoms but does it have the science behind it to make a considerable difference .

[manc10] 08/11/2018 18:42

avanti have got more problems than skin 65 million market cap and 450 million of debt avanti a stonking sell at 3p micheal

[danatkins] 08/11/2018 18:15

hxxps://www.newbeauty.com/hottopic/blogpost/9219-ingredients-that-get-under-your-skin/

[danatkins] 08/11/2018 18:13

It's a fair point. I'm not a skin expert but found this article somewhat intetesting. For what I can tell its all about the active ingredient penitrateing the skin. This can be difficult however amino acids and parts of proteins can effectively penetrate the skin. The lysate would fall into this category and would/should penetrate the skin. Still very interestingand valid point. st/9219-ingredients-that-get-under-your-skin/

[michaelmouse] 08/11/2018 17:12

Actually note that the industry standard is UP TO 12 hours for the reasons outlined above.

[michaelmouse] 08/11/2018 17:10

I've just listened to the presentation from the CEO - DR Cath O'Neill which is prominently displayed on their website. I was curious to see if I'm missing something since this is a pre-revenue company with a heady valuation of around £20m.

There is a BIG concern here, and it relates to yesterday's RNS.

Why would anybody be interested in a moisturising effect that takes 24 hours to kick in?

Here's the problem. When you apply any moisturising cream there is an assumption by the user that the effects are almost instantaneous. Therefore you apply the cream after washing your face or hands or after showering on a fairly regular basis.

In 24 hours you'll have washed your hands numerous times and showered at least twice (hopefully?). You'll have reapplied the cream several times since every time you wash you've considerably diluted any effect it might have had.

So what's the point in a technology that doesn't start to kick in until 24 hours later unless you only have a bath once a week say? (It'll work for you slarty ;))

Now bear that in mind and read this paragraph again from yesterday, and common sense will tell you why 12 hours is the industry standard. The moisturising effects are next to zilch in this time period, and it's the crucial time period:-

"The moisturisation effect of the SkinBiotix(R) technology was tested in a 12 hour study - an industry standard test - using 21 healthy subjects. In this study, the cream containing SkinBiotix(R) was applied to an area of skin and the moisture content of the skin was measured for up to 12 hours. The moisturising effect of the cream without the technology was also measured as a control for comparison. As in-house laboratory tests have indicated that SkinBiotix(R) requires at least 24 hours to produce its effects, no difference was anticipated when compared against the control."

"The cream containing SkinBiotix(R) provided good moisturisation which was generally higher than that provided by the control cream but the difference was not significant."

Food for thought isn't it?

[riskybusiness1] 08/11/2018 16:10

The 12 hour study is industry standard and has no relevance whatsoever to SBTX technology and its effectiveness. Any partner will reformulate the cream base. The only news really is that it's passed safety and irritancy which is very good news. How they've made it look bad again is beyond me.

[rafboy] 08/11/2018 16:10

May be the wording was poor but Cath was quite clear that these results were important on the safety front etc and the cream passed these tests. Anyway, I am quite sure that this will all be forgotten in 6 months time when the cream has been shown to work well in the third test.

[danatkins] 08/11/2018 16:09

Agree the RNS is clear just that humans like to read between lines which from from a scientific perspective is not very imperical. The RNS gave the facts

[judijudi] 08/11/2018 16:05

As I said, there was a disappointing sentence, poorly worded
imho

"The cream containing SkinBiotix(R) provided good moisturisation which was generally higher than that provided by the control cream but the difference was not significant"

[rafboy] 08/11/2018 16:01

It was spelt out in the RNS that the cream is effective after 24 hours and not 12 hours as per the test. People need to read the RNS again as there were no negatives from these results.

[judijudi] 08/11/2018 15:56

I agree with luminoso
The results/wording were imho slightly disappointing. Hense the drop in the SP

This was the sentence from the RNS that was the weak link
"The cream containing SkinBiotix(R) provided good moisturisation which was generally higher than that provided by the control cream but the difference was not significant"

But its the effectiveness over longer term tials that really count

[riskybusiness1] 08/11/2018 15:52

Moisturising benefits were as good as expected for the time frame. Even better that they found no dry skin from the effects. Facts are the safety and irritant studies passed excellently.Unfortunately they have worded another rns poorly. I'm not sure why they'd be releasing the results of a moisture test testing the moisture ability of the cream with SBTX in comparison to a control over 12 hours. I know this is an industry standard but they've even stated in the RNS SBTX technology produces effects from 24hrs. This industry test therefore is simply a test on the cream (which will be irrelevant to SBTX as the cream will be reformulated by different partners).Huge great news overlooked by wording and too much unnecessary detail. The main results are that it has passed safety and irritant studies with flying colours. Huge risk averted. Instead of this great news it could be looked upon as not great like they did with the RNS on stability testing, which ended up not delaying studies at all.

[danatkins] 08/11/2018 15:50

Not sure why folks bang on with the moisturiser element. I know not the same but I've had minor skin inventions where I've applied cream and it took on average 4 days to see a marked improvement. I don't know why they done a 12 hour test, maybe because they had an opportunity to get this done. 12 hours is really a small amount of time.

[rafboy] 08/11/2018 15:43

Luminoso, it was in line with expectations. They clearly stated that the cream works after 24 hrs and not the 12 tested. The tests were about safety and the cream passed that. I think you may be trying to mislead people. Read the RNS.

[luminoso] 08/11/2018 15:09

Moisturizing benefit results were disappointing quite frankly.
Maybe the larger trial will improve on that.

[danatkins] 08/11/2018 13:28

No interview. Dr cath may do interview once 3rd trial is announced to start. Hopefully sooner than later

[anderson3] 08/11/2018 13:20

Any proactive interview?

[matt123d] 08/11/2018 11:53

Looking weak here, managed to short a few, 15/16p area next support area

[2350220] 08/11/2018 10:53

Ha ha, you sure wouldn't think so, if you just checked the share price!
John

[jammyjim] 07/11/2018 17:53

Tailormaiden. I can’t see how Costax Helped in any way by ranmping and then leaving. I hold a large quantity in both shares and have done for quite some time. Informative posts do a lot more good Than people Who try and think they can push the price up by saying £30 by the end of October. I still take note of certain peoples hard work and effort that can be shared on these sites. Thank you

[manc10] 07/11/2018 16:26

SkinBiotix will move on the third and main element of the human study, which will involve 120 volunteers with self-assessed dry skin, to analyse the longer term moisturisation effects and impact on skin barrier function of the SkinBiotix technology.

[danatkins] 07/11/2018 15:49

Some folks thought easy money on these results but it's the final result that will lift the stock. May drift a little if folks get bored or results may support the share price until next news. Although only a small initial trail planned for 3rd (I think 10 people) if positive then folks may take an early position for the remainder due 2019

[taylormaiden] 07/11/2018 15:44

jammyjim - 12 Sep 2018 - 21:00:11 - 41290 of 42853 OptiBiotix - Better Science, Better Health. Better buy some! - OPTI
There were some very informative people on this site that have given the confidence and information to others to help with making decisions. I saw a few of those names from the past crop up yesterday. All i see now are a few idiots Who Probably haven’t got a clue what 220 percent profit feels like. If you donâ€482;t own shares here please go and sit in the park with your bottle of Cider.
===================================================================================

He soon changed his tune. Presumably the same informative people are now the rampers.

[rafboy] 07/11/2018 15:39

The results were in line with expectations and show it is safe to use. What more did you expect from these initial results.