Poolbeg Pharma Share Discussion Threads

[muchodinero] 04/7/2023 08:21

Well in that case you'd think they would go down the rout that the Flu-V vaccine had been developed by Hvivo and is stage 3 ready.

[supernumerary] 03/7/2023 22:12

Still lots of space for effective flu vaccines...



First-gen mRNA flu vaccines 'will not win,' Sanofi execs admit as they retool strategy

First-generation mRNA vaccines for flu “will not win,” Sanofi executives have admitted as they set out plans to develop more advanced candidates they believe will overcome the technology’s existing shortfalls.

The biggest names in messenger RNA like Moderna, Pfizer and CureVac are all working on their own influenza candidates, but Sanofi used a vaccines investor event yesterday to spell out bluntly why those initial attempts to target the technology on flu just won’t work.

At the event, the French Big Pharma unveiled trial data putting its hemagglutinin-based mRNA vaccine up against the company’s approved quadrivalent flu vaccine Fluzone. In an echo of the underwhelming data posted by Moderna earlier this year for its own candidate, Sanofi’s mRNA shot performed well against influenza strain A but struggled against strain B.

“The immune response we observed with our platform is very similar to that observed with other mRNA vaccines,” Sanofi’s head of translational medicine Saranya Sridhar, M.D., Ph.D., told attendees at the London event. “And what that tells us is that improving on the standard of care, the minimum bar against which all mRNA vaccines need to be compared, is difficult.”

The fact that Sanofi’s competitors are also struggling to tackle B strains “suggests to us that low flu B responses are probably a class effect across mRNA platforms,” Sridhar explained.

[ ... ]

[muchodinero] 03/7/2023 19:53

I think Enrique Elrico should stick to singing, as his share tipping leaves a lot to be desired.

[chica1] 03/7/2023 14:31

Oh undoubtedly he's being chatting to his buddy 'the Unmentionable One'.
Remember Elrico interviewed him on a number of occasions when he was talking claptrap to the detriment of many of The Orphan Army.

One wonders if Cytoreason 'rediscovered' FLU-V as a one of its multiple novel drug targets.
Perhaps in the near future they'll guide us on how they define 'multiple'

I am aware getting drug candidates to market is a slow tedious process and I haven't lost faith in Jeremy

[muchodinero] 03/7/2023 13:35

Chico, Senor Elrico appears to knows no more than the rest of us. I wonder if just another company mouthpiece?

[chica1] 03/7/2023 12:51

So Elrico re your comment..

'If you do not understand the significant nature of yesterday's RNS, then I would argue POLB is too complicated for you. It was a highly significant RNS that opened many out-license doors with one or multiple big pharma.'

Why aren't Investors piling in if the news is so significant?

[chica1] 29/6/2023 19:33

Yep one just arrived at 5:24.

Credibility is the key.There are hundreds of Biotech's working on projects in the infectious disease space.
Even Trout said it could be years to get to market if at all.
You need to stand out from the crowd to be noticed.

Moniman,legaleagle.muchodineo (whatever you want to call him)even though we have our differences and me want to be cheerleaders here but you have to call a spade a spade.

[muchodinero] 29/6/2023 17:08

Lol, you're right again...I wonder how long JS and the team can drag this Capital Light nonsense on for?

[chica1] 29/6/2023 16:29

And there you have it.

Jeremy shud know the market wants more meat!

[muchodinero] 29/6/2023 12:09

Chica, that's the first sensible thing you've said in ages...lol..Where's the Polb-001 miracle drug disappeared to?

[chica1] 29/6/2023 10:11

Trout if the news was significant we'd have bounced alot higher

Unfortunately I see alot of fluff in the rns.

[troutisout] 29/6/2023 10:01

I know it's raining but why is everyone on a downer?
News is good, the future looks better and yet again the Company have kept to their timeline and aims....

[1gw] 29/6/2023 09:53

If we're talking cynical, or perhaps the word is sceptical, why do companies use the word "multiple" when they could just give a number. Do they really mean 2? The cynic/sceptic in me says "multiple" means a very small number, albeit greater than 1.

[chica1] 29/6/2023 09:11

Speaking of being cynical.
Poolbeg's parent company has a 49% stake in a Phase 3 ready Universal Flu Vaccine and can't get funding.
I thought this rns would have more meat to it.
It's a case of show me the money I'm afraid.

[troutisout] 29/6/2023 09:07

Logical rather than cynical, if there was a 660k sell on the opening you might have a point, the logic says it was hard this week to get any offer in size, the Company had well signposted this event before end of H2, the price was much cheaper last month and the news although positive, was sort of known, as they were hardly going to keep us waiting on the outcome is it wasn't positive. They would have canned it and told us earlier.
Insider trading, Why? This news is great but the results from it won't be seen for months, if not years.

[shrewdmole] 29/6/2023 08:50

Great article Elric!

Well that’s the sell on news brigade done so expect it to climb back during the day now.

[judijudi] 29/6/2023 07:47

Nice one Elric

[lfdkmp] 29/6/2023 07:47

Not so cynical as myself then trout. :-)

[troutisout] 29/6/2023 07:44

I think that was being worked all week, I have bought several times this week and on trying could not get offers in any size and when I did buy the offer ticked up every time.
We all knew these results were due by end of month, I think we have had a large buyer for the last few weeks, the MMs moving the price up and down to fill their orders...

[adorling] 29/6/2023 07:42

Hugely significant RNS given the speed that AI is developing across the world and also in Global Drug discovery.

[lfdkmp] 29/6/2023 07:28

"Yep 660k odd someone’s confident."


Yes, very confident that there would be a positive RNS in the morning.

Well, glad they weren't disappointed.

[1gw] 29/6/2023 07:11

Reads well. "Multiple" new targets should keep the IP team busy and provide plenty of scope for out-licensing in due course.

[mrmarmalade] 29/6/2023 07:07

Great RNS....

[shrewdmole] 28/6/2023 17:46

Yep 660k odd someone’s confident.