Miscellaneous

     
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( BW)(ELI-LILLY-&-CO)(BC43) Miscellaneous

   Business Editors 
   UK REGULATORY NEWS

   INDIANAPOLIS--(BUSINESS WIRE)--Aug. 26, 2002

              New Data Suggest Painful Physical Symptoms
 are Common in Depression; Results Highlight Need for More Effective
                      Recognition and Treatment

More than eighty percent of people with depression also experience
painful physical symptoms as part of their illness, according to an
18-month study of more than 18,000 patients in six countries. These
data were shared with physicians and researchers attending the World
Psychiatric Association 12th World Congress of Psychiatry in Yokohama,
Japan.

"This is one of the largest studies of its kind to date," said
Prof. Donald Patrick, Ph.D, MSPH, University of Washington, Seattle.
"The study clearly shows a link between emotional and painful physical
symptoms since patients with these physical symptoms were nearly three
times more likely to also have high depressive symptoms."

The study highlights include:

--  80 percent of depressed patients experienced pain.

--  Patients with painful physical symptoms were 2.25 to 3.29
    times as likely to experience high depressive symptoms.

--  Nearly 40 percent of patients visiting a primary care
    physician had symptoms of depression. Of those, 80 percent
    also experienced pain.

--  An increase in pain symptoms was associated with an increase
    in depressive symptoms.

--  The findings were consistent in all countries.

"This study has confirmed that physical symptoms are very common
in depressive disorders. General practitioners and other doctors often
don't recognize these disorders, particularly when physical symptoms
are prominent in the clinical picture," said Norman Sartorius, M.D.,
Ph.D., past president of the World Psychiatric Association. "This was
a large study carried out in different countries and continents that
provided important data about depressive disorders and their outcome.
This data could be very valuable in developing training and service
programs to address the needs of many patients with physical symptoms
who are not currently receiving the treatments they need."

Recent medical literature suggests that relief of certain
depressive symptoms, including aches and pains, require the
combination of two neurotransmitters in the brain - both serotonin and
norepinephrine. An imbalance of these neurotransmitters may explain
the presence of painful physical symptoms in patients with depression.
The descending serotonin and norepinephrine pathways, in the brain and
spinal cord, regulate the painful physical symptoms of depression.(1)

Methodology

The data arise from the Longitudinal Investigation of Depression
Outcomes (LIDO) study administered at six international primary care
centers in Australia, Brazil, Israel, Spain, the Russian Federation
and the United States. In the 18-month study, 18,456 patients were
screened for depression using the Center for Epidemiological Studies
Depression Scale. The CES-D is a 20-item scale with a range from 0 to
60. Higher scores indicate a greater severity of depression. Scores
greater than or equal to 16 constituted highly depressive symptoms.
Pain was reported by patients using a Likert-type item on the
interference of pain. Patients were asked to report how much their
pain interfered with their normal work and functioning.

Patients were excluded if they were currently receiving medication
for depression or had received treatment for depression within the
last three months. Furthermore, patients were also excluded if they
had been previously diagnosed with a major psychiatric disorder or
psychoses or diagnosed with a disorder such as Alzheimer's disease
that would interfere with the study objectives.

Study Information

Eli Lilly and Company sponsored the LIDO study and Health Research
Associates, Inc. served as the study administrator. LIDO's primary
objective was to assess the quality of life and economic correlates of
major clinical depression in primary care settings.

Current medical literature shows that only one third of the
patients taking today's most widely prescribed antidepressants achieve
complete remission of their symptoms. Lilly continues its search to
pursue answers for the unmet medical needs that still exist in
depression.

Lilly Information

Lilly, a leading innovation-driven corporation, is developing a
growing portfolio of best-in-class pharmaceutical products by applying
the latest research from its own worldwide laboratories and from
collaborations with eminent scientific organizations. Headquartered in
Indianapolis, Ind., Lilly provides answers - through medicines and
information - for some of the world's most urgent medical needs.
Additional information about Lilly is available at www.lilly.com.

(1) Stahl SM, Journal of Clinical Psychiatry; 2002

   Short Name: Lilly (Eli) & Co
   Category Code: MSC
   Sequence Number: 00000675
   Time of Receipt (offset from UTC): 20020826T145414+0100

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    CONTACT:  Eli Lilly and Company
              Anne Griffin, 317/276-3254

    KEYWORD: INDIANA UNITED KINGDOM INTERNATIONAL EUROPE
    INDUSTRY KEYWORD: MEDICAL PHARMACEUTICAL BANKING
    SOURCE: Lilly (Eli) & Co

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