Integumen Share Discussion Threads

[monkey puzzle] 01/10/2020 11:30

hxxp://www.global-engage.com/event/labskin-virtual-lab-tour/

Combining the Labskin lab-grown 3D skin models and Labskin’s ability to harvest and replicate the skin microbiome of a human volunteer, the Remote Clinical Trial platform is an innovative, problem-solving platform which guarantees accurate, socially-distanced product-testing capabilities for cosmetics and skin care brands. During the webinar Paul Ryan and Alex Chapman will take you through the Labskin laboratory facility in the UK with a virtual tour, followed by an in-depth presentation of the Remote Clinical Trial platform and a case study that will guide you through the Remote Clinical Trial journey from a client perspective.

A live and moderated Q&A session will close out the webinar, and questions can be directed here.

Date: 20 October 2020

Time: New York – 11:00 | London – 16:00 | Paris – 17:00 | Singapore – 23:00 |Tokyo – 00: 00 (21 October) |Sydney – 01:00 (21 October)
Duration: 75 minutes
Event structure: Virtual lab tour, 2 presentations and Q&A

Registration fee: Complimentary access

Webinar on-demand: Available to view until midnight 4 November 2020 (registration is required)

Labskin’s pioneering approach to testing skin care products by cloning a patient’s skin microbiome and transplanting it on to Labskin human skin equivalent allows a wide range of testing that no longer requires invasive procedures on patients. Data from next generation sequencing of the Labskin and skin biome is coupled with AI processes to interpret and direct further development of skincare products in a controlled and efficient manner, reducing development time and costs.

[monkey puzzle] 01/10/2020 09:48

Thanks John, at least us real investors here can appreciate what SKIN and MWG are doing. The constant naysayers are irritating but irrelevant in the end.

[grosstonnage] 01/10/2020 09:42

new info having a positive effect on share price

[2350220] 01/10/2020 09:35

Yeah, that's my point ArgyleRich.
More and more, I can't help thinking that the £4m Y/E forecast GB has stated several times, will be beat.
At least I certainly hope so 😊
John

[argylerich] 01/10/2020 09:28

John this has been referred to by GB before but never revealed. First time I've heard that it's another 'university' lab too.

[cocker] 01/10/2020 09:03

Seems like the resident Chimp who is suppose to have moved over to the LSE bb is rather rattled again. The negativity that some of us have shown towards GC is more than fair given the success of "operation Helium" last week. It wouldn't hurt to remember to watch out for "who's snouts are feeding out of the same trough", would it.

[2350220] 01/10/2020 08:51

From Monkey Puzzle's excellent post above (which only received 2 likes??)
I noticed this sentence:
"We are now working with two leading universities with Containment Level 3 labs".
We've all known about the Aberdeen University lab, but when did they add the use of a 2nd university CL3 lab?
For them to need a 2nd, highly saught-after lab must mean that they are expanding the Covid side of things I imagine.
John

[smraynot] 01/10/2020 08:51

Keep smiling 🚀🚀🚀🚀8640;

[46maxon] 01/10/2020 08:38

Need to put you into hibernation for a while. It was 1p a few months back.

[homeboy] 01/10/2020 08:36

well, the market still aint behind this even after the mum's net usa MoU, next they'll announce the uk neighbourhood watch - surrey branch - will look at installing a device to make sure mrs whoever is flushing her en-suite correctly.

[homeboy] 01/10/2020 08:32

best to filter these rampant cut and paste merchants like freshfart
they really do think that the amount of column inches they can clog a bb up with somehow equates to a successful business

it's rather sad

[monkey puzzle] 01/10/2020 08:22

GT, you might not like the answer if I recall JJ's views on GB.

[grosstonnage] 01/10/2020 08:21

Judiwhat do you mean?

[judijudi] 01/10/2020 08:12

The fall out caused by our very unprofessional (imho) CEO continues

[yump] 01/10/2020 08:11

Well done with that post. Filling up the thread with a cut and paste says it all when you could just summarise and post a link.

Don’t you know how to use a discussion board ?

[monkey puzzle] 01/10/2020 07:21

RE: A re-imagined look at skin model testing – Q&A with LabskinWed 23:17
2/2

China still mandates that cosmetics safety has to be tested in animals although recent announcements have lifted restrictions on importing cosmetic products with alternative methods for safety assessment. The Chinese regulator is looking to establish alternatives in vitro standards to animal testing. Labskin is in an excellent position to become a key part of the new regulatory environment emerging in the Chinese cosmetics market.

In January 2020 Labskin signed a Memorandum of Understanding with the Innocare Group to promote innovation and cooperation on regulatory compliance without animal testing. To make our skin models more relevant to Asian markets, Labskin is collaborating with the University of Bradford to develop a model containing melanocytes so that next-generation skin models can be created using cells from donors with different ethnic backgrounds. Melanin is a natural sink of chemical compounds so different level of pigmentation could become an important factor not only for safety testing and efficacy.

Looking ahead 10 or 20 years from now, what does the future hold for the lab–grown human skin model? How far can you go?

At this point, there is no limit to what we can do with skin models. The most urgent matter to address is adding extra complexity. This includes the need for melanocytes and Langerhans cells, sourced to improve the immune response of the models. Research demonstrates that this is possible; it just needs to be commercially produced. The next step will be to add complex macrostructures, such as hair follicles, sweat and sebaceous glands, possibly by reprogramming stem cells. Blood vessels could be developed inside a 3D model like Labskin as we know that seeding endothelial cells into a skin model produces a self-organized microvasculature.

A combination of these techniques and 3D bioprinting will give rise to a new generation of skin models with blood/lymphatic vessels that could be connected to a microfluidic system, similar to our circulatory system, wired to keep the skin alive. All of this improvement combined with further developments in acute, chronic toxicology and efficacy will result in improved models.

hxxps://connect.in-cosmetics.com/news-category/testing-regulations/a-reimagined-look-at-skin-model-testing-qa-with-labskin/

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A re-imagined look at skin model testing – Q&A with LabskinWed 23:16
1SEPTEMBER 29, 2020

1/2

* An interview with David Caballero-Lima, R&D Manager, Labskin

Labskin has been around for twelve years – can you tell us about the history of the company as well as your field of expertise?

The Labskin model was created by a group of microbiologists at the University of Leeds to study the skin human microbiota and the microbial/host interaction in a controlled environment. Labskin has unique features, including its improved barrier function, dry surface and the expression of antimicrobial peptides which allow the colonization of the model with skin microbiome. We use these defining characteristics to develop methods for testing ingredients and formulations on the microbial community on Labskin.

We colonise Labskin with different microbial consortia containing mixes of skin bacteria and fungi. We can also isolate the whole microbiome from volunteers and transplant this microbiome onto Labskin. We can even challenge those consortia or microbiomes with pathogens. Then, combining a range of techniques such as colony counting, RT-qPCR, immunohistochemistry, ELISA or sequencing; we are able to look at the effect of those products on both the host and the microbiota at the same time.

We can’t avoid the obligatory question about Covid-19 and testing sanitizers… you collaborate with various universities and academics…any exciting initiatives you can share with us?

We regularly carry out tests on skin sanitisers, soaps and cleansers using our commensal skin consortia and specific pathogens. In the lab, our standard methods for testing sanitisers against the virus implement the most robust safety measures. We are now working with two leading universities with Containment Level 3 biosafety levels for specific laboratory work on SARS–CoV2.

Most data on the efficacy of hand sanitisers against the Covid-19 virus do not correlate to a real-life situation. We use our Labskin model to get data in an environment that closely resembles real human skin. Additionally, we isolate microbiome from volunteers and have developed methods to isolate those microbiomes without contact with the subject. In effect, we run remote clinical trials that use an internet portal to recruit and send swabs to the volunteers and recover the whole microbiomes from those volunteers to safely transplant them onto our skin models in our facilities.

[monkey puzzle] 01/10/2020 07:19

hxxps://connect.in-cosmetics.com/news-category/testing-regulations/a-reimagined-look-at-skin-model-testing-qa-with-labskin/

[monkey puzzle] 01/10/2020 07:16

The Chinese regulator is looking to establish alternatives in vitro standards to animal testing. Labskin is in an excellent position to become a key part of the new regulatory environment emerging in the Chinese cosmetics market.’

[yump] 30/9/2020 23:49

i036327

Snap ! I knew a lot about it as in the affiliate world and their stuff was flying off 3rd party sites well before they floated. Right products, online taking off, celebrityness just taking off.

Banked a big profit thinking the best was over. Then it went on to 10 bag+ again. You just don't know and anyone that pretends they do is a fat fibber. imo buy and hold does not work overall and has not for a lot of years. Just because it would have worked with a few stocks if you happen to have held them, doesn't mean its a great strategy.

It also means you would have to buy and hold every stock you held, as you don't know which ones are going to make it really big.

[abbynat] 30/9/2020 23:35

last two posts honest assesments of this stock mkt merry go round!