I have no idea why I bought this, continue to hold since 2007, even after the Haleon split there seems little direction. |
Hesham Abdullah, Senior Vice President, Global Head Oncology,R&D,GSK is a busy man signing off on RNS 's covering 3 different products within a week. |
I've been steadily increasing my position here based on that theory. Nevertheless frustrating when bad news sends shares plummeting but good news doesn't result in any uplift. At some point there will be a reversal, due to M&A activity or whatever. In the meantime we just have to grin and bear it. |
It takes a long time for mkts to work out they are wrong, and that is where the opportunity lies |
Two bits of good news but the share price continues to fall. Seems to be a bit of a disconnect. Longer term this could be a blockbuster for these indications. It’s a longer term hold for me. |
GSK plc (LSE/NYSE: GSK) announced today that the US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for Jemperli (dostarlimab) for the treatment of patients with locally advanced mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) rectal cancer. The Breakthrough Therapy Designation aims to expedite the development and review of drugs with the potential to treat a serious condition and where preliminary clinical evidence may indicate substantial improvement over currently available therapy. This is the second regulatory designation for dostarlimab in locally advanced dMMR/MSI-H rectal cancer, following Fast Track designation for the same patient population in January 2023 |
Seven analysts have rated GSK with a hold rating and four have assigned a strong buy rating to the stock. |
She's doing fine |
Yep 1300 on the cards again |
Every chart for this horrific, prob a buy to trade again around 12.80, rinse and repeat. U.K. shares known as “ the bug zapper trade “ for a reason. |
 Two stocks to buy in a cheap sector
There are a couple of companies in this sector that have been oversold and are being tipped to do well. Another remains one to avoid, writes Graeme Evans.
AstraZeneca and Novo Nordisk are the leading picks and GSK is still one to avoid after a City bank revealed its 2025 forecasts for an “inexpensive” European pharma sector.
Bank of America said the industry’s fundamentals remain strong, with the European majors set to deliver another year of market-beating earnings growth in the region of 14%.
However, this has been offset by stock-specific issues and the potential for uncertainty over healthcare policy in the sector’s single largest and most profitable market of the US.
As a result, European pharma trades on 12 times forecast 2026 earnings. That’s a slim 3% premium to the wider market, whereas the long-term average is 12%.
The bank believes the weakness since September has been overdone and that valuations are too focused on risks rather than growth and the potential of pipelines. Its target multiple of 16 times implies a 30% total return potential if overhangs are removed.
Despite its multiple of seven times 2026 earnings making GSK
GSK
0.34%
one of the lowest-rated stocks in the sector, the bank continues to have an Underperform recommendation.
This reflects headwinds for vaccines Arexvy and Shingrix, as well as GSK having the worst post-2026 growth outlook in the sector due to the loss of exclusivity on key products.
The shares are down 9% this year, despite the company recently ending two years of uncertainty by setting aside $2.2 billion to settle 93% of Zantac litigation claims.
Third-quarter results in late October showed vaccine sales fell 15%, impacted by a tough comparative and the prioritisation of Covid vaccinations in the United States.
Shingles product Shingrix dropped 7% as lower demand in the US more than offset stronger international uptake. And the respiratory syncytial virus vaccine Arexvy also missed City targets by some distance, with a 72% decline to £188 million.
The pressure on GSK shares and other European pharma stocks continued at the end of November after president-elect Donald Trump nominated vaccine-sceptic Robert F. Kennedy Jr as health secretary.
While this brings the prospect of four years of uncertainty over healthcare policy, Bank of America believes this is already reflected in the sector's discounted P/E multiple. |
Five shares to watch for 2025
GSK
GSK logo
Quality and value
Pharmaceutical company GSK is becoming a dependable name for raising and meeting guidance. That may not continue forever, but even after coming up against some headwinds in the vaccines franchise, it’s on track to meet its twice upgraded guidance for 2024.
The financial progress is underpinned by excellence in research and development that’s seen 11 positive late stage clinical updates from recent results, and is expected to yield five major product approvals next year. Beyond vaccines, the group also has a strong presence in HIV treatments, which make up about 20% of total revenues. Its newer treatments are a key part of GSK's future, as generic competitors eat away at pricing power for some of the group's legacy treatments, and sales growth in the category remains healthy. The smaller oncology division is growing very rapidly, with promising growth drivers in both existing treatments and the development pipeline.
However, the pharmaceutical industry comes with high exposure to changes in the political landscape as well as the inherent risk of failed clinical trials so investors should be prepared for disappointments.
More recently, the valuation’s been held back by litigation relating to the heartburn drug Zantac. We believe developments on that front have materially reduced a key risk. But that’s not been enough to offset investor concerns around the US performance of two key products, Arexvy and Shingrix.
Given the impact on next year’s forecasts have been fairly limited, the continued pressure on the valuation looks to be overdone, which could offer an attractive entry point to an impressive business. And on the plus side, valuation weakness has helped push the forward prospective dividend yield to 4.9%. As ever, no returns are guaranteed. |
cumnor as a new buyer of GSK stock the past is irrelevant to me. All that matters is the price today and the potential going forward. |
Meant the latter.. |
But the problem was that 80p was based on unsustainable borrowing and the plan was to a) cheekily offload a lot of debt on Haleon and b) grow the pipeline and sales (and by extension the dividend) by focusing on vaccines and a few therapeutic pharma areas. But, of course, it's hard to take a divi reduction when valuation has also collapsed. But how much of the former is actually poor sentinent rather than a true reflection of how the company is faring at this point? |
No longer acceptable 60p divi-should be 80p 2025-to attract any institutional interest in present environment. Emma messed up and no mention of progressive dividend policy recent update. Investors have no confidence in her ability, and so they just unload shares at every opportunity. |
Share price back down and almost 2% in USA |
5 shares for 2025
Quality and value
Pharmaceutical company GSK is becoming a dependable name for raising and meeting guidance. That may not continue forever, but even after coming up against some headwinds in the vaccines franchise, it’s on track to meet its twice upgraded guidance for 2024.
The financial progress is underpinned by excellence in research and development that’s seen 11 positive late stage clinical updates from recent results, and is expected to yield five major product approvals next year. Beyond vaccines, the group also has a strong presence in HIV treatments, which make up about 20% of total revenues. Its newer treatments are a key part of GSK's future, as generic competitors eat away at pricing power for some of the group's legacy treatments, and sales growth in the category remains healthy. The smaller oncology division is growing very rapidly, with promising growth drivers in both existing treatments and the development pipeline.
However, the pharmaceutical industry comes with high exposure to changes in the political landscape as well as the inherent risk of failed clinical trials so investors should be prepared for disappointments.
More recently, the valuation’s been held back by litigation relating to the heartburn drug Zantac. We believe developments on that front have materially reduced a key risk. But that’s not been enough to offset investor concerns around the US performance of two key products, Arexvy and Shingrix.
Given the impact on next year’s forecasts have been fairly limited, the continued pressure on the valuation looks to be overdone, which could offer an attractive entry point to an impressive business. And on the plus side, valuation weakness has helped push the forward prospective dividend yield to 4.9%. As ever, no returns are guaranteed. |
Look at the way share price goes down a total disgrace . |
I doubt it means anything but anyone else notice the last year's chart looks like a massive head and shoulders? :0 |
1300 to nearly 1400 pence did not take too long here on the upward leg, hopefully we are back on the every 2 year cycle of rising towards 1800 again now.. :o) |
GSK plc announced that the FDA has accepted its regulatory filing, seeking the approval of a new indication for Nucala (mepolizumab) in chronic obstructive pulmonary disease (COPD) treatment for review. A decision from the regulatory body is expected on May 7, 2025. |
Blenrep could be worth more than £3billion in annual sales for GSK if it comes to market. |
 LONDON - GSK plc announced significant overall survival (OS) results from the DREAMM-7 trial, which showed a 42% reduction in the risk of death for patients treated with Blenrep (belantamab mafodotin) in combination with bortezomib and dexamethasone (BVd), compared to a daratumumab-based regimen. The data, presented at the 66th American Society of Hematology (ASH) Annual Meeting, could potentially reshape the standard of care for multiple myeloma patients at or after first relapse.
The trial, which included 494 participants, revealed that the three-year OS rate was 74% in the BVd arm versus 60% in the daratumumab combination arm, with the survival benefit observed as early as four months. Although the median overall survival was not reached in either study arm, projections suggest a median OS of 84 months for BVd, compared to 51 months for the daratumumab combination.
In addition to the OS benefit, the Blenrep combination demonstrated a greater than 2.5-fold improvement in minimal residual disease (MRD) negativity rate, indicating no detectable cancer cells, compared to the daratumumab combination. The results also included improvements in other key secondary efficacy endpoints, such as duration of response (DOR) and progression-free survival 2 (PFS 2), suggesting deeper and more durable responses with BVd.
The safety profile of the Blenrep combination was consistent with previous analyses, with manageable and resolvable eye-related side effects, leading to a low treatment discontinuation rate. The trial's findings build upon earlier results from the DREAMM-7 and DREAMM-8 trials, which demonstrated improvements in progression-free survival.
Regulatory reviews of Blenrep combinations based on the DREAMM-7 and DREAMM-8 trials are underway in several major markets, including the US, European Union, Japan, China, United Kingdom (TADAWUL:4280), Canada, and Switzerland. The DREAMM clinical development program continues to assess the potential of belantamab mafodotin in various treatment combinations and settings. |
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