Holding(s) in Company

RNS Number:1496H
Cambridge Antibody Tech Group PLC
06 February 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1) Name of company

Cambridge Antibody Technology

2) Name of shareholder having a major interest

Wellington Management Company, LLP

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18

Non Beneficial

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

Interests held in various accounts (the "Accounts") for which Wellington
Management Company acts as a discretionary investment manager - names of the
Accounts not disclosed.


5) Number of shares/amount of stock acquired

Not disclosed

6) Percentage of issued class

Not disclosed

7) Number of shares/amount of stock disposed

N/A

8) Percentage of issued class

N/A

9) Class of security

Ordinary 10 pence shares

10) Date of transaction

Not disclosed

11) Date company informed

5 February 2003

12) Total holding following this notification

1,150,053


13) Total percentage holding of issued class following this notification

3.16%

14) Any additional information

None

15) Name of contact and telephone number for queries

Justin Hoskins, 01223 471471

16) Name and signature of authorised company official responsible for
making this notification

Diane Mellett, Company Secretary


Date of notification 6 February 2003


SCHEDULE 10

NOTIFICATION OF MAJOR INTERESTS IN SHARES

1) Name of company

Cambridge Antibody Technology

2) Name of shareholder having a major interest

FMR Corp, Fidelity International Limited and Edward Johnson 3d

3) Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a
non-beneficial interest or in the case of an individual holder if it is a
holding of that person's spouse or children under the age of 18

Non Beneficial

4) Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

Chase Nominees Limited (906,876), HSBC (1,012,375), Chase Manhattan Bank London
(5,382), Chase Nominees Ltd (260,299),Bankers Trust (277,628) MSS Nomiees Ltd
(22,700), Nortrust Nominees Ltd (89,500), RBS Trust Bank (121,937), Northern
Trust (40,600), BT Globenet Nominees Ltd (47,900), Bank of New York - London
(36,400), JP Morgan (17,253), Bank of New York Brussels (23,400), State Street
Bank & Trust (8,900)

5) Number of shares/amount of stock acquired

Nil

6) Percentage of issued class

Not Applicable

7) Number of shares/amount of stock disposed

283,936

8) Percentage of issued class

0.78%

9) Class of security

Ordinary 10 pence

10) Date of transaction

Not disclosed

11) Date company informed

5 February 2003

12) Total holding following this notification

2,871,150


13) Total percentage holding of issued class following this notification

7.9%

14) Any additional information

The interests notified do not act as a group or in concert in respect of the
interest notified.

15) Name of contact and telephone number for queries

Justin Hoskins

16) Name and signature of authorised company official responsible for
making this notification

Diane Mellett, Company Secretary


Date of notification 6 February 2003




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