Holding(s) in Company

RNS Number:9809V
Cambridge Antibody Tech Group PLC
20 December 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company



Cambridge Antibody Technology Group plc



2. Name of shareholder having a major interest



Franklin Resources Inc.



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18



Bank of New York                            non beneficial

JP Morgan Chase Bank                        non beneficial

Citibank Nominees Limited                   non beneficial

State Street Bank                           non beneficial



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them



Bank of New York                            24,570

JP Morgan Chase Bank                     1,311,223

Citibank Nominees Limited                   14,780

State Street Bank                          840,207



5. Number of shares / amount of stock acquired



not disclosed



6. Percentage of issued class



not known



7. Number of shares / amount of stock disposed



None



8. Percentage of issued class



N/A



9. Class of security



Ordinary 10 pence shares



10. Date of transaction



Not disclosed



11. Date company informed



20 December 2005



12. Total holding following this notification



2,190,780



13. Total percentage holding of issued class following this notification



4.136%



14. Any additional information



The disclosure has been made on behalf of Franklin Resources, Inc and its
affiliates which includes Franklin Mutual Advisers, LLC and Templeton Worldwide,
Inc. Franklin Resources, Inc and its affiliates perform investment management
advisory and related services for clients on a global basis.



15. Name of contact and telephone number for queries



Justin Hoskins 01223 898589



16. Name and signature of authorised company official responsible for making
this notification



Justin Hoskins, Company Secretary



Date of notification



20 December 2005



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for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
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