Holding(s) in Company

RNS Number:6747U
3i Bioscience Investment Trust PLC
27 January 2004

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

3i Bioscience Investment Trust plc

2. Name of shareholder having a major interest

Deutsche Bank AG

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Deutsche Bank AG and its subsidiary companies

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Registered holder                                            Number of shares
Deutsche Bank AG London                                      4,556,016
Deutsche Bank AG International                               10,250

Total                                                        4,566,266

5. Number of shares / amount of stock acquired

not known

6. Percentage of issued class

not known

7. Number of shares / amount of stock disposed

not known

8. Percentage of issued class

not known

9. Class of security

Ordinary shares of 25p each

10. Date of transaction

not known

11. Date company informed

27 January 2004

12. Total holding following this notification

4,566,266

13. Total percentage holding of issued class following this notification

10.21%

14. Any additional information

1.   Part of this holding may relate to hedging arrangements for Deutsche Bank AG customer transactions.

2.   Companies within the Deutsche Bank AG group acting as Fund Managers hold some of the shares on behalf
of a number of clients whose portfolios are managed on a discretionary basis.

15. Name of contact and telephone number for queries
Pandora Sharp - 020 7975 3228

16. Name and signature of authorised company official responsible for making
this notification

For and on behalf of 3i plc, Secretaries to 3i Bioscience Investment Trust plc

Date of notification
27 January 2004






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