Holding(s) in Company

RNS Number:1629Q
BioFocus PLC
25 September 2003

BIOFOCUS PLC

25 SEPTEMBER 2003



BioFocus plc ("the Company"))



The Company has received notifications:



*               Following a recent sale, Dr Valerie Rose no longer holds a
notifiable interest in the Company.



*               Notification was received from ISIS Asset Management Plc, dated
19 September 2003, that as a result of a purchase of 175,000 ordinary shares,
the Friends Provident Group and its Fund Management Companies are interested in
the shares below through client holdings:



ISIS Asset Management Plc is interested in the following shares:


No. of Shares                                                                      %


2,281,802                                                                          14.32



This includes the following client of Friends Provident Unit Managers referred
to below who has a material interest.


Name of Client                        No. of Shares %          Name of Registered Holder


Stewardship Growth Fund               536,059       3.36       Chase Nominees



This also includes the following client of Friends Provident Corporate Pensions
Limited referred to below who has a material interest:


Name of Client                        No. of Shares %          Name of Registered Holder


FPCP Stewardship Fund                 544,059       3.41       HSBC GS Nominees Ltd



In addition, ISIS Asset Management plc, as the holding company of the companies
referred to above is also interested in those shares.  Furthermore, Friends
Provident Life Office, as the holding company of Friends Ivory & Sime plc is
also interested in the shares referred to above.



*               Notification was received from ISIS Asset Management Plc, dated
23 September 2003, that as a result of a purchase of 50,000 ordinary shares,
Active Capital Trust, a client of ISIS Asset Management Plc, holds 516,748
ordinary shares representing 3.24%.  These shares are registered in the name of
Chase Nominee.







END




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