Merck: Hepatitis C Drug Shows 98% Cure Rate in Mid-Stage Trial

By Michael Calia 

Merck & Co. said Thursday that a pair of its hepatitis C virus treatments showed a cure rate of 98% in a mid-stage trial, supporting advancement of the study.

The drug maker said it has initiated a Phase 3 trial after analyzing the study results of the 12-week regimen using the treatments, MK-5172 and MK-8742. The company said the study also showed a 94% cure rate for patients receiving those treatments, plus ribavirin.

The company said there were no early discontinuations of the treatment due to adverse effects, nor were any significant abnormalities detected. The most common side effects were fatigue, headache, nausea, diarrhea and insomnia, Merck said.

Merck has taken some hits lately as it contends with patent expirations on lucrative drugs, as well as issues with bringing new products to the marketplace. Last year, the company said it would cut its workforce by 20% over two years, including cutting positions in its research and development operations. The company has also said it would consider shedding some products and businesses.

The company in February said it agreed to collaborate with other drug makers to study its investigational cancer treatment.

Shares of Merck rose 1.8% to $58.10 in recent premarket trading. Through Wednesday's close, the stock was up 14% so far this year.

Write to Michael Calia at [e-mail]

Subscribe to WSJ: http://online.wsj.com?mod=djnwires