AstraZeneca, Merck Say Lynparza Trial Shows Long-Term Survival Increase

By Dean Seal

AstraZeneca PLC and Merck & Co. said Friday that long-term follow-up results for trials of its Lynparza treatment showed improved long-term survival for patients with advanced ovarian cancer.

The companies, which jointly developed and commercialized the medication, said a five-year follow-up of one trial showed 65.5% survival in patients treated with Lynparza combined with bevacizumab compared with 48.4% survival in a group given bevacizumab and a placebo.

A seven-year follow-up of another trial showed 67% survival in advanced ovarian cancer patients with BRCA mutations who received Lynparza, compared with 47% in a placebo group.

Susan Galbraith, AstraZeneca's executive vice president of oncology research and development, said the five-year survival rate of newly diagnosed patients with advanced ovarian cancer is 30% to 50%.

"In that context, it is phenomenal to share the long-term overall survival data from both PAOLA-1 and SOLO-1, with two out of three patients still alive in these trials," she said.

Write to Dean Seal at [e-mail]

(END) Dow Jones Newswires

September 09, 2022 08:56 ET (12:56 GMT)

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