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Share Name | Share Symbol | Market | Type |
---|---|---|---|
Shattuck Labs Inc | NASDAQ:STTK | NASDAQ | Common Stock |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.06 | 1.35% | 4.49 | 4.45 | 4.51 | 4.59 | 4.49 | 4.54 | 8,870 | 15:07:43 |
“The data presented from these two compounds demonstrate the broad utility of the GADLEN platform to direct gamma delta T cells to kill target cells expressing an antigen (or antigens) of our choosing,” said Taylor Schreiber, M.D., Ph.D., Chief Executive Officer of Shattuck. “B7-H3 is an antigen that is broadly expressed by many solid tumors, with limited expression in normal tissues. In our preclinical models, our B7-H3 GADLEN directed human gamma delta T cells to selectively kill B7-H3 expressing human tumor cells, including those that expressed very low density of the B7-H3 antigen. Similarly, in our preclinical models, our CD20 GADLEN directed human gamma delta T cells to selectively kill both CD20 expressing tumor cells, and also CD20 expressing healthy B cells. The latter activity with the CD20 GADLEN may have distinct value in antibody-mediated autoimmunity, where non-Ig, non-CD3 based cell depletion strategies could have a unique therapeutic window.”
Details of the presentation are as follows:
Abstract title: Antigen targeted butyrophilin heterodimer-based bispecific engagers induce T cell-mediated anti-tumor activity
Shattuck presented preclinical data highlighting the potential of GADLENs to direct Vγ9δ2+ T cells to kill tumor cells. The bispecific GADLENs, which contain heterodimeric BTN2A1 and BTN3A1 extracellular domains fused via inert Fc linkers to scFv domains, targeting CD20 or B7-H3 antigens, demonstrated cytotoxic ability in coculture with Vγ9δ2+ T cells. CD20-directed GADLENs enhanced the specific killing of lymphoma cells and healthy B cells that express the antigen, while B7H3-directed GADLEN increased the killing of B7-H3 expressing tumor cells. These studies shed light on the modularity of the GADLEN platform and the tumor cell markers which are important for the therapeutic activity of gamma delta T cell-based engager therapies.
Further information about the Society for Immunotherapy of Cancer Meeting can be found at: https://www.sitcancer.org/2022/home. The poster will be available on the Posters section of the Company’s website shortly after the event.
About Shattuck Labs, Inc.Shattuck Labs, Inc. (NASDAQ: STTK) is a clinical-stage biotechnology company pioneering the development of bi-functional fusion proteins as a new class of biologic medicine for the treatment of patients with cancer and autoimmune disease. Compounds derived from Shattuck’s proprietary Agonist Redirected Checkpoint, ARC®, platform simultaneously inhibit checkpoint molecules and activate costimulatory molecules with a single therapeutic. The company’s SL-172154 (SIRPα-Fc-CD40L) program, which is designed to block the CD47 immune checkpoint and simultaneously agonize the CD40 pathway, is being evaluated in multiple Phase 1 trials. A second product candidate, SL-279252 (PD1-Fc-OX40L), is being evaluated in a Phase 1 trial in solid tumors or lymphomas. Additionally, the company is advancing a proprietary Gamma Delta T Cell Engager, GADLEN™, platform, which is designed to bridge gamma delta T cells to tumor antigens for the treatment of patients with cancer. Shattuck has offices in both Austin, Texas and Durham, North Carolina. For more information, please visit: www.ShattuckLabs.com.
The Company intends to use the investor relations portion of its website as a means of disclosing material non-public information and for complying with disclosure obligations under Regulation FD.
Investor Contact:Conor RichardsonSenior Director, Finance & Investor RelationsShattuck Labs, Inc.InvestorRelations@shattucklabs.com
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