Schrödinger Provides Update on Progress Across the Business and Outlines 2025 Strategic Priorities

Announces Expanded Research Collaboration Agreement with Otsuka Pharmaceutical Co., Ltd.

On Track to Report Initial Phase 1 Data from Three Proprietary Programs in 2025

Focus on Delivering Continued Software Growth and Increased Drug Discovery Revenue

Schr�dinger, Inc. (Nasdaq: SDGR) today provided an update on its progress across the business in 2024 and announced its strategic priorities for 2025.

“We are very proud of our accomplishments in 2024. We advanced the capabilities of our computational platform and leveraged the synergies in our business, which included signing a multi-target research collaboration and expanded software licensing agreement with Novartis. We are pleased another innovative pharmaceutical company is engaged with us through both large-scale utilization of our software and through drug discovery collaborations,” stated Ramy Farid, Ph.D., chief executive officer at Schr�dinger. “We have a very important year ahead of us and are committed to driving growth in our software business, advancing our collaborative pipeline and reporting initial Phase 1 data from our three lead proprietary therapeutic programs.”

Additionally, today Schr�dinger announced that it has expanded its research collaboration with Otsuka Pharmaceutical Co., Ltd., to add another undisclosed target to the collaboration. The terms of the expanded collaboration are consistent with the previously announced agreement.

Schr�dinger also announced that its research collaboration with Novartis has received regulatory clearance, and Schr�dinger expects to receive the upfront payment of $150 million from Novartis in the first quarter of 2025.

2024 Achievements Today Schr�dinger highlighted several 2024 achievements, including the following:

Platform

• Launched its initiative to expand the company’s computational platform to predict toxicology risk early in drug discovery, which is being funded by $19.5 million in grants from the Bill & Melinda Gates Foundation
• Launched LiveDesign Biologics, an informatics solution for drug discovery teams designing biologics, which builds upon the company’s existing, small molecule-focused, LiveDesign offering
• Published 29 peer-reviewed articles in life sciences and materials science journals

Proprietary Pipeline

• Continued to advance its Phase 1 clinical study of SGR-1505, its MALT1 inhibitor, in patients with relapsed/refractory B-cell lymphomas and its Phase 1 clinical study of SGR-2921, its CDC7 inhibitor, in patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndrome
• Initiated a Phase 1 clinical study of SGR-3515, its Wee1/Myt1 inhibitor, in patients with advanced solid tumors
• Received FDA Fast Track Designation for SGR-2921 for the treatment of relapsed/refractory acute myeloid leukemia
• Presented preclinical data on SGR-3515, its Wee1/Myt1 inhibitor, at the EORTC-NCI-AACR Symposium

Collaborators, Partners, and Co-Founded Companies

• Announced a multi-target research collaboration and license agreement with Novartis, including a $150 million upfront payment and up to $2.3 billion in milestone payments plus royalties, as well as an expanded software licensing agreement, which substantially increases Novartis’ access to Schr�dinger’s computational platform to industry-leading scale
• Ajax Therapeutics, a company co-founded by Schr�dinger, initiated a Phase 1 clinical trial for its lead program, AJ1-11095 and completed a Series C financing, in which Schr�dinger participated as a continuing investor
• Morphic Holding, Inc., a company co-founded by Schr�dinger, was acquired by Lilly for approximately $3.2 billion, resulting in approximately $48 million in cash for Schr�dinger, with Schr�dinger remaining entitled to low single-digit royalties on selected pipeline programs, including MORF-057, its orally administered α4β7 inhibitor
• Nimbus, a company co-founded by Schr�dinger, presented updated Phase 1/2 data for NDI-101150, its HPK1 inhibitor, at the Society for Immunotherapy of Cancer Annual Meeting
• Structure Therapeutics, a company co-founded by Schr�dinger, presented Phase 1b/2a data for GSBR-1290, its oral GLP-1 agonist, in obesity and diabetes at the Annual Meeting of the America Diabetes Association
• Structure Therapeutics also announced the selection of ACC-2671, its novel oral small molecule amylin receptor agonist for further development in obesity
• Copernic Catalysts, a Schr�dinger research partner in materials science, raised an oversubscribed financing round, in which Schr�dinger participated as a continuing investor

2025 Strategic Priorities Today Schr�dinger outlined the following strategic priorities for 2025:

• Drive increased customer adoption of its computational technology and enterprise informatics platform
• Advance the science underlying the platform, including progressing the predictive toxicology initiative
• Present initial data from the Phase 1 study of SGR-1505 in patients with relapsed/refractory B-cell lymphomas in the first half of 2025
• Present initial data from the Phase 1 study of SGR-2921 in patients with relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndrome in the second half of 2025
• Present initial data from the Phase 1 study of SGR-3515 in patients with advanced solid tumors in the second half of 2025
• Advance proprietary and collaborative discovery portfolio

Schr�dinger will report its fourth quarter and full-year financial results and provide 2025 financial guidance on Wednesday, February 26, 2025, after the financial markets close. The company will host a conference call and webcast at 4:30 p.m. ET.

About Schr�dinger Schr�dinger is transforming molecular discovery with its computational platform, which enables the discovery of novel, highly optimized molecules for drug development and materials design. Schr�dinger’s software platform is built on more than 30 years of R&D investment and is licensed by biotechnology, pharmaceutical and industrial companies, and academic institutions around the world. Schr�dinger also leverages the platform to advance a portfolio of collaborative and proprietary programs and is advancing three clinical-stage oncology programs. Founded in 1990, Schr�dinger has approximately 900 employees operating from 15 locations globally. To learn more, visit www.schrodinger.com, follow us on LinkedIn and Instagram, or visit our blog, Extrapolations.com.

Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including but not limited to those regarding the potential advantages of our computational platform, our research and development efforts for our proprietary drug discovery programs and our platform, the initiation, timing, progress, and results of our proprietary drug discovery programs and the drug discovery programs of our collaborators, the clinical potential and favorable properties of our MALT1, CDC7, and Wee1/Myt1 inhibitors, including SGR-1505, SGR-2921, SGR-3515, and other compounds discovered with our platform, our ability to discover, identify and advance development candidates under our collaboration with Novartis, our ability to realize potential milestones, royalties or other payments under our collaboration with Novartis, the risk that we may not realize the expected benefits of our collaboration with Novartis, the clinical potential and favorable properties of our collaborators’ product candidates, including Ajax Therapeutics, Nimbus Therapeutics and Structure Therapeutics, and our ability to realize milestones, royalties, and other payments from our collaborative and proprietary programs, our plans to discover and develop product candidates and to maximize their commercial potential by advancing such product candidates ourselves or in collaboration with others, our plans to leverage the synergies between our businesses, our strategic priorities and plans, and our progress towards achieving our strategic priorities are forward-looking statements. Statements including words such as “aim,” "anticipate," "believe," "contemplate," "continue," "could," "estimate," "expect," “goal,” "intend," "may," "might," "plan," "potential," "predict," "project," "should," "target," "will," "would" and statements in the future tense are forward-looking statements. These forward-looking statements reflect our current views about our plans, intentions, expectations, strategies and prospects, which are based on the information currently available to us and on assumptions we have made. Actual results may differ materially from those described in the forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and factors that are beyond our control, including the demand for our software solutions, our ability to further develop our computational platform, our reliance upon our third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and our ability to initiate and complete preclinical studies and clinical trials, uncertainties associated with the regulatory review of clinical trials and applications for marketing approvals, the ability to retain and hire key personnel and other risks detailed under the caption "Risk Factors" and elsewhere in our Securities and Exchange Commission filings and reports, including our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2024, as well as future filings and reports by us. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, we undertake no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.

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