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Share Name | Share Symbol | Market | Type |
---|---|---|---|
Prelude Therapeutics Inc | NASDAQ:PRLD | NASDAQ | Common Stock |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.14 | 3.93% | 3.70 | 3.65 | 3.74 | 3.88 | 3.51 | 3.61 | 9,052 | 19:44:57 |
“This additional data from our solid tumor trial investigating our potent and selective CDK9 inhibitor, PRT2527, continues to support a best-in-class safety and target engagement profile for the molecule. A second Phase 1 clinical trial in patients with hematological cancers is also underway, with initial data expected in 1H 2024,” stated Jane Huang, MD, President and Chief Medical Officer, Prelude Therapeutics.
Dr. Huang added, “We also presented our initial clinical data with our differentiated brain and tissue penetrant next generation CDK4/6 inhibitor, PRT3645, demonstrating a generally well-tolerated safety profile and high target inhibition reaching levels needed for efficacy in preclinical studies.”
Clinical Poster Presentations:
Title: A Phase 1 Dose-Escalation Study of PRT2527, a Cyclin-Dependent Kinase 9 (CDK9) Inhibitor, in Adult Patients with Advanced Solid Tumors: An Updated Analysis
Summary:
Title: A Phase 1 Open-Label, Dose-Escalation Study of Central Nervous System–Penetrant Cyclin-Dependent Kinase (CDK)4/6 Inhibitor PRT3645 in Patients with Select Advanced or Metastatic Solid Tumors
Summary
Preclinical Poster Presentations:
“In addition to the preclinical efficacy we have seen with our potent and selective SMARCA2 degrader, PRT3789, as monotherapy, we see added potential in combination with immunotherapies as well as with chemotherapy and targeted therapies, such as KRAS inhibitors. The sensitive and quantitative assays we have developed to measure SMARCA2 degradation in preclinical models will also enable us to assess target engagement in the clinic. We look forward to the translation of these preclinical results in clinical readouts planned for 2024,” said Peggy Sherle, Ph.D., Chief Scientific Officer of Prelude Therapeutics.
Title: Discovery of PRT3789, a First-in-Class Potent and Selective SMARCA2 Degrader in Clinical Trials for the Treatment of Patients with SMARCA4 Mutated Cancers
Summary:
Title: Clinical Biomarkers Based on PK/PD Modeling to Guide the Development for a First-in-Class, Highly Selective SMARCA2 (BRM) Degrader, PRT3789
Summary:
About Prelude Therapeutics
Prelude Therapeutics is a clinical-stage precision oncology company developing innovative drug candidates targeting critical cancer cell pathways. The Company’s diverse pipeline is comprised of highly differentiated, potentially best-in-class proprietary small molecule compounds aimed at addressing clinically validated pathways for cancers with selectable underserved patients. Prelude’s pipeline includes four candidates currently in clinical development: PRT1419, a potent, selective inhibitor of MCL1, PRT2527, a potent and highly selective CDK9 inhibitor, PRT3645 a next generation CDK4/6 inhibitor, and PRT3789 an IV administered, potent and highly selective SMARCA2 degrader, and a preclinical oral candidate targeting SMARCA2.
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Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, anticipated discovery, preclinical and clinical development activities for Prelude’s product candidates and the potential benefits of Prelude’s product candidates. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. Although Prelude believes that the expectations reflected in such forward-looking statements are reasonable, Prelude cannot guarantee future events, results, actions, levels of activity, performance or achievements, and the timing and results of biotechnology development and potential regulatory approval is inherently uncertain. Forward-looking statements are subject to risks and uncertainties that may cause Prelude's actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to Prelude's ability to advance its product candidates, the receipt and timing of potential regulatory designations, approvals and commercialization of product candidates, clinical trial sites and our ability to enroll eligible patients, supply chain and manufacturing facilities, Prelude’s ability to maintain and recognize the benefits of certain designations received by product candidates, the timing and results of preclinical and clinical trials, Prelude's ability to fund development activities and achieve development goals, Prelude's ability to protect intellectual property, and other risks and uncertainties described under the heading "Risk Factors" in documents Prelude files from time to time with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release, and Prelude undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date hereof.
Investor Contact:Lindsey TrickettVice President, Investor Relations240.543.7970ltrickett@preludetx.com
Media Contact:Helen ShikShik Communications 617.510.4373Helen@ShikCommunications.com
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