Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * FROST PHILLIP MD ET AL	2. Issuer Name and Ticker or Trading Symbol OPKO HEALTH, INC. [ OPK ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director                    __X__ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) CEO & Chairman
(Last)          (First)          (Middle) OPKO HEALTH, INC., 4400 BISCAYNE BLVD.	3. Date of Earliest Transaction (MM/DD/YYYY) 8/5/2022
(Street) MIAMI, FL 33137 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) ___ Form filed by One Reporting Person _ X _ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock								3068951	D
Common Stock	8/5/2022		P		300	A	$2.245	196606994	I	See Footnote (1)
Common Stock	8/5/2022		P		7350	A	$2.25	196614344	I	See Footnote (1)
Common Stock	8/5/2022		P		400	A	$2.255	196614744	I	See Footnote (1)
Common Stock	8/5/2022		P		1600	A	$2.259	196616344	I	See Footnote (1)
Common Stock	8/5/2022		P		9869	A	$2.26	196626213	I	See Footnote (1)
Common Stock	8/5/2022		P		700	A	$2.265	196626913	I	See Footnote (1)
Common Stock	8/5/2022		P		400	A	$2.27	196627313	I	See Footnote (1)
Common Stock	8/5/2022		P		300	A	$2.2701	196627613	I	See Footnote (1)
Common Stock	8/5/2022		P		500	A	$2.2725	196628113	I	See Footnote (1)
Common Stock	8/5/2022		P		49249	A	$2.275	196677362	I	See Footnote (1)
Common Stock	8/5/2022		P		27700	A	$2.28	196705062	I	See Footnote (1)
Common Stock	8/5/2022		P		35734	A	$2.285	196740796	I	See Footnote (1)
Common Stock	8/5/2022		P		24400	A	$2.29	196765196	I	See Footnote (1)
Common Stock	8/5/2022		P		52210	A	$2.295	196817406	I	See Footnote (1)
Common Stock	8/5/2022		P		600	A	$2.2975	196818006	I	See Footnote (1)
Common Stock	8/5/2022		P		2364	A	$2.2984	196820370	I	See Footnote (1)
Common Stock	8/5/2022		P		3500	A	$2.299	196823870	I	See Footnote (1)
Common Stock	8/5/2022		P		69986	A	$2.30	196893856	I	See Footnote (1)
Common Stock	8/5/2022		P		11375	A	$2.305	196905231	I	See Footnote (1)
Common Stock	8/5/2022		P		804	A	$2.31	196906035	I	See Footnote (1)
Common Stock	8/5/2022		P		43656	A	$2.315	196949691	I	See Footnote (1)
Common Stock	8/5/2022		P		7003	A	$2.32	196956694	I	See Footnote (1)
Common Stock								30127177	I	See Footnote (2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:
(1)	The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
(2)	These securities are held by Frost Nevada Investments Trust, of which the Reporting Person is the trustee and Frost-Nevada, L.P. is the sole and exclusive beneficiary. The Reporting Person is one of seven limited partners of Frost-Nevada, L.P. and the sole shareholder of Frost-Nevada Corporation, the sole general partner of Frost-Nevada, L.P. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
FROST PHILLIP MD ET AL OPKO HEALTH, INC. 4400 BISCAYNE BLVD. MIAMI, FL 33137	X	X	CEO & Chairman
Frost Gamma Investments Trust 4400 BISCAYNE BLVD. MIAMI, FL 33137		X

Signatures
Phillip Frost, M.D., Individually and as Trustee		8/8/2022
**Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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