Statement of Changes in Beneficial Ownership (4)

FORM 4

[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

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3235-0287

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * McVey Richard M	2. Issuer Name and Ticker or Trading Symbol MARKETAXESS HOLDINGS INC [ MKTX ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director                    _____ 10% Owner __X__ Officer (give title below)    _____ Other (specify below) Chairman & CEO
(Last)          (First)          (Middle) C/O MARKETAXESS HOLDINGS INC., 55 HUDSON YARDS, 15TH FLOOR	3. Date of Earliest Transaction (MM/DD/YYYY) 2/10/2020
(Street) NEW YORK, NY 10001 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock, par value $0.003 per share	2/10/2020		S(1)		1210	D	$335.67 (2)	974734	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		3677	D	$336.68 (3)	971057	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		2103	D	$337.66 (4)	968954	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		5395	D	$338.85 (5)	963559	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		3151	D	$339.76 (6)	960408	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		5649	D	$340.65 (7)	954759	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		3713	D	$341.80 (8)	951046	D
Common Stock, par value $0.003 per share	2/10/2020		S(1)		102	D	$342.24 (9)	950944	D
Common Stock, par value $0.003 per share								2000	I	By Immediate Family Members

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:
(1)	This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
(2)	The transactions were executed in multiple trades at prices ranging from $335.12 to $336.10. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(3)	The transactions were executed in multiple trades at prices ranging from $336.18 to $337.16. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(4)	The transactions were executed in multiple trades at prices ranging from $337.22 to $338.19. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(5)	The transactions were executed in multiple trades at prices ranging from $338.24 to $339.15. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(6)	The transactions were executed in multiple trades at prices ranging from $339.23 to $340.18. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(7)	The transactions were executed in multiple trades at prices ranging from $340.22 to $341.19. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(8)	The transactions were executed in multiple trades at prices ranging from $341.21 to $342.19. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.
(9)	The transactions were executed in multiple trades at prices ranging from $342.23 to $342.50. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
McVey Richard M C/O MARKETAXESS HOLDINGS INC. 55 HUDSON YARDS, 15TH FLOOR NEW YORK, NY 10001	X		Chairman & CEO

Signatures
/s/ Jason Edelstein, as Attorney-in-Fact for Richard M. McVey		2/12/2020
**Signature of Reporting Person		Date