Bruker BioSpin 1.7mm MicroCryoProbe(TM) Wins R&D 100 Award for Delivering a Tenfold Jump in NMR Sensitivity for Small Sample Amo

  
    
  
  
    
      A 2008 R&D 100 Award has been presented to Bruker BioSpin for its 1.7mm 
      triple resonance NMR MicroCryoProbe™ with 
      breakthrough sensitivity on an active volume of only 30 microliters. The 
      1.7mm MicroCryoProbe™ together with the MRI 
      CryoProbe™ are two innovations from Bruker 
      BioSpin selected by the independent judging panel and editors of R&D 
      Magazine in 2008 for this prestigious award.
    
    
      This novel MicroCryoProbe™ offers an increase 
      in mass sensitivity of more than an order of magnitude, which makes the 
      1.7 mm MicroCryoProbe™ an ideal tool for any 
      Nuclear Magnetic Resonance (NMR) analysis with limited sample amounts, 
      e.g. natural products, drug metabolites, isolated low abundance 
      proteins, peptides or small molecules, or difficult-to-express proteins.
    
    
      Conventional room-temperature NMR microprobes with 5 and 30 micro liter 
      volumes have become popular in areas such as natural products chemistry, 
      drug metabolism, protein NMR and drug screening applications. The 
      introduction of a cryogenically cooled MicroCryoProbe™ 
      is of significant importance for researchers working with very limited 
      sample quantities, e.g. natural products isolated in minute quantities 
      from a variety of organisms, or protein samples that have been prepared 
      in small scale expression systems.
    
    
      The significant increase in sensitivity is achieved by cryogenically 
      cooling both detection coil and preamplifier together with proprietary 
      high-sensitivity electronics design. For a given sample amount, a 6-fold 
      gain over a conventional 1.7 mm microprobe and about a 10-14-fold gain 
      over a conventional 5 mm probe are obtained. This can lead to a 200-fold 
      reduction in experiment time, or alternatively it fundamentally enables 
      NMR research with very low sample quantities that previously would 
      simply not have been possible or practical.
    
    
      “Bruker’s 
      MicroCryoProbe™ offers incredible mass 
      sensitivity, and enables us to obtain data on natural product sample 
      obtained from a single sea mollusc that we collected 15 years ago but 
      were unable to acquire NMR data on because of insufficient sample 
      amount. Now with the 1.7mm MicroCryoProbe™ 
      we've solved the structures of these molecules,” 
      said Ted Molinski, Professor at the Skaggs School of Pharmacy and 
      Pharmaceutical Sciences at University of California San Diego.
    
    
      “Many of our customers have urged us to 
      develop a MicroCryoProbe™,” 
      said Mr. Oskar Schett, a Managing Director of Bruker BioSpin. “It 
      was clear that after the successes of both our 5mm CryoProbes and our 
      conventional microprobes a combination of the two technologies was the 
      next logical step to further lower the detection limits of NMR for the 
      characterization of many samples that were considered not measurable by 
      NMR”.
    
    
      ABOUT BRUKER BIOSPIN: For more information about Bruker BioSpin 
      and Bruker Corporation (NASDAQ: BRKR), please visit www.bruker-biospin.com 
      and www.bruker.com.