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Share Name | Share Symbol | Market | Type |
---|---|---|---|
Altimmune Inc | NASDAQ:ALT | NASDAQ | Common Stock |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.1099 | 1.72% | 6.4949 | 6.49 | 6.50 | 6.67 | 6.30 | 6.39 | 1,070,467 | 16:10:06 |
“These data, coupled with MOMENTUM Phase 2 obesity trial results that showed class-leading lean mass preservation in body composition, further reinforce the opportunity for pemvidutide to distinguish itself broadly from approved therapies and other clinical candidates targeting MASH and obesity,” said Vipin K. Garg, Ph.D., President and Chief Executive Officer of Altimmune. “The balanced GLP-1 and glucagon dual agonism of pemvidutide represents a potentially differentiated approach to achieving clinically meaningful reductions in body weight, liver fat, and lipids to ameliorate MASH and address the many MASH-associated co-morbidities.”
The data presented are summarized below:
WED-212 (Abstract #3002): Pemvidutide treatment is associated with improvement in non-invasive tests indicating greater likelihood of histologic response in subjects with metabolic dysfunction-associated steatotic liver disease: a 24-week, randomized, double-blind, placebo-controlled trial
WED-219 (Abstract #2881): Pemvidutide, a glucagon-like peptide 1/glucagon dual receptor agonist, improves metabolic dysfunction-associated steatohepatitis activity and fibrosis in a clinical quantitative systems pharmacology model
WED-251 (Abstract #2985): Plasma lipidomic profiling of subjects with overweight or obesity following treatment with the glucagon-like peptide 1/glucagon dual receptor agonist pemvidutide: an investigation of lipid signatures associated with metabolic dysfunction-associated steatohepatitis
The posters presented at the EASL International Liver Congress™ 2024 are accessible on the Events section of the Altimmune website.
About PemvidutidePemvidutide is a novel, investigational, peptide-based GLP-1/glucagon dual receptor agonist in development for the treatment of obesity and MASH. Activation of the GLP-1 and glucagon receptors is believed to mimic the complementary effects of diet and exercise on weight loss, with GLP-1 suppressing appetite and glucagon increasing energy expenditure. Glucagon is also recognized as having direct effects on hepatic fat metabolism, which is believed to lead to rapid reductions in levels of liver fat and serum lipids. In clinical trials to date, once-weekly pemvidutide has demonstrated compelling weight loss, robust reductions in triglycerides, LDL cholesterol, liver fat content and blood pressure. The U.S. FDA has granted Fast Track designation to pemvidutide for the treatment of MASH. Pemvidutide recently completed the MOMENTUM Phase 2 obesity trial and is being studied in the ongoing IMPACT Phase 2b MASH trial.
About AltimmuneAltimmune is a clinical-stage biopharmaceutical company focused on developing innovative next-generation peptide-based therapeutics. The Company is developing pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of obesity and MASH. For more information, please visit www.altimmune.com.
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Company Contact:Richard EisenstadtChief Financial OfficerPhone: 240-654-1450ir@altimmune.com
Investor Contacts:Lee RothBurns McClellanPhone: 646-382-3403lroth@burnsmc.com
Julia WeilmanBurns McClellanPhone: 646-732-4443jweilman@burnsmc.com
Media Contact:Danielle CanteyInizio Evoke, BiotechPhone: 619-826-4657Danielle.cantey@inizioevoke.com
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