Alpine Immune Sciences Announces Participation in January Investor Conferences

Alpine Immune Sciences, Inc. (NASDAQ: ALPN), a leading clinical-stage immunotherapy company focused on developing innovative treatments for cancer and autoimmune and inflammatory diseases, today announced that members of its management team will present at the following investor conferences in January 2022:

H.C. Wainwright BIOCONNECT Virtual Conference Date: Monday, January 10, 2022 Time: Available on demand beginning 7:00 a.m. ET/4:00 a.m. PT Event: Company Presentation

J.P. Morgan Healthcare Conference Date: Thursday, January 13, 2022 Time: 12:00 p.m. ET/9:00 a.m. PT Event: Company Presentation

Webcasts of the H.C. Wainwright, and J.P. Morgan presentations will be available online in the investor relations section of the company’s website at https://ir.alpineimmunesciences.com/events. A replay of the presentations will be available on the company website for 90 days following the webcast.

About Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. is committed to leading a new wave of immune therapeutics. With world-class research and development capabilities, a highly productive scientific platform, and a proven management team, Alpine is seeking to create first- or best-in-class multifunctional immunotherapies via unique protein engineering technologies to improve patients’ lives. Alpine has entered into strategic collaborations with leading global biopharmaceutical companies and has a diverse pipeline of clinical and preclinical candidates in development. For more information, visit www.alpineimmunesciences.com. Follow @AlpineImmuneSci on Twitter and LinkedIn.

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Investor Relations Alex Sharif Director, Investor Relations and Corporate Development Alpine Immune Sciences, Inc 206-788-4545 [e-mail]

Media Relations Kelli Perkins Red House [e-mail]