Alnylam to Report New Patisiran and Revusiran Results at the XV International Symposium on Amyloidosis

Company to Host Conference Call on Friday, July 1, 2016, at 8:30 am ET to Discuss Results

Alnylam Pharmaceuticals, Inc. (Nasdaq:ALNY), the leading RNAi therapeutics company, announced today that Alnylam scientists and collaborators will present preliminary results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis) at the XV International Symposium on Amyloidosis (ISA) held July 3-7, 2016 in Uppsala, Sweden.

All posters by Alnylam scientists and collaborators will be presented during the poster session on July 4, 2016. Presentations include:

• Phase 2 open-label extension study of patisiran, an investigational RNAi therapeutic for the treatment of hereditary ATTR amyloidosis with polyneuropathyAuthor: Teresa Coelho, Hospital Santo Antonio, Centro Hospitalar do Porto, Porto, Portugal

• Phase 2 open-label extension study of revusiran, an investigational RNAi therapeutic for the treatment of patients with transthyretin amyloidosis with cardiomyopathy: Updated interim resultsAuthor: Julian D Gillmore, National Amyloidosis Centre, UCL Medical School; London, United Kingdom

• Patisiran, an investigational RNAi therapeutic for the treatment of hereditary ATTR amyloidosis with polyneuropathy: Baseline demographics from the phase 3 APOLLO studyAuthor: Ole B Suhr, Umeå University; Umeå, Sweden

• Relationship between TTR knockdown and change in mNIS+7: Preliminary correlation findings from the phase 2 open-label extension study of patisiran, an investigational RNAi therapeutic for hereditary ATTR amyloidosis with polyneuropathyAuthor: David Adams, CHU Bicêtre (APHP), Université Paris-Sud; Paris, France

The Company will host a conference call on Friday, July 1, 2016, at 8:30am ET to discuss these results. To access the call, please dial 877-312-7507 (domestic) or 631-813-4828 (international) five minutes prior to the start time and refer to conference ID 36431889. A replay of the call will be available beginning at 10:30 a.m. ET on July 1, 2016. To access the replay, please dial 855-859-2056 (domestic) or 404-537-3406 (international), and refer to conference ID 36431889.

A live audio webcast of the call will be available on the Investors section of the company's website, www.alnylam.com. An archived webcast will be available on the Alnylam website approximately two hours after the event.

About Alnylam Pharmaceuticals

Alnylam is a biopharmaceutical company developing novel therapeutics based on RNA interference, or RNAi. The company is leading the translation of RNAi as a new class of innovative medicines. Alnylam’s pipeline of investigational RNAi therapeutics is focused in 3 Strategic Therapeutic Areas (STArs): Genetic Medicines, with a broad pipeline of RNAi therapeutics for the treatment of rare diseases; Cardio-Metabolic Disease, with a pipeline of RNAi therapeutics toward genetically validated, liver-expressed disease targets for unmet needs in cardiovascular and metabolic diseases; and Hepatic Infectious Disease, with a pipeline of RNAi therapeutics that address the major global health challenges of hepatic infectious diseases. In early 2015, Alnylam launched its “Alnylam 2020” guidance for the advancement and commercialization of RNAi therapeutics as a whole new class of innovative medicines. Specifically, by the end of 2020, Alnylam expects to achieve a company profile with 3 marketed products, 10 RNAi therapeutic clinical programs – including 4 in late stages of development – across its 3 STArs. The company’s demonstrated commitment to RNAi therapeutics has enabled it to form major alliances with leading companies including Merck, Medtronic, Novartis, Biogen, Roche, Takeda, Kyowa Hakko Kirin, Cubist, GlaxoSmithKline, Ascletis, Monsanto, The Medicines Company, and Sanofi Genzyme. In addition, Alnylam holds an equity position in Regulus Therapeutics Inc., a company focused on discovery, development, and commercialization of microRNA therapeutics. Alnylam scientists and collaborators have published their research on RNAi therapeutics in over 200 peer-reviewed papers, including many in the world’s top scientific journals such as Nature, Nature Medicine, Nature Biotechnology, Cell, New England Journal of Medicine, and The Lancet. Founded in 2002, Alnylam maintains headquarters in Cambridge, Massachusetts. For more information about Alnylam’s pipeline of investigational RNAi therapeutics, please visit www.alnylam.com.

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Investors and Media:Alnylam Pharmaceuticals, Inc.Christine Regan Lindenboom, 617-682-4340orInvestors:Josh Brodsky, 617-551-8276