Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person * Pugh Gordon G	2. Issuer Name and Ticker or Trading Symbol Alkermes plc. [ ALKS ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director                      _____ 10% Owner __ X __ Officer (give title below)      _____ Other (specify below) SVP, COO & CRO, Alkermes, Inc.
(Last)          (First)          (Middle) 852 WINTER ST.	3. Date of Earliest Transaction (MM/DD/YYYY) 12/12/2016
(Street) WALTHAM, MA 02451 (City)        (State)        (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares	12/12/2016		G	V	1794	D	$0	45987	I	Gordon G. Pugh Revocable Trust - 2012
Ordinary Shares	12/14/2016		G	V	7250	D	$0	38737	I	Gordon G. Pugh Revocable Trust - 2012
Ordinary Shares	12/15/2016		M (1)		16690	A	$16.55	37277	D
Ordinary Shares	12/15/2016		S (2)		16690	D	$57.6225   (3)	20587	D
Ordinary Shares	12/16/2016		M (1)		4768	A	$16.55	25355	D
Ordinary Shares	12/16/2016		S (2)		4768	D	$57.7318   (4)	20587	D
Ordinary Shares								13101	I	Nancy E. Pugh Revocable Trust - 2012
Ordinary Shares								6989	I	By GRAT   (5)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (Right to Buy)	$16.55	12/15/2016		M   (1)			16690	(6)	5/21/2022	Ordinary Shares	16690	$0	4768	D
Employee Stock Option (Right to Buy)	$16.55	12/16/2016		M   (1)			4768	(6)	5/21/2022	Ordinary Shares	4768	$0	0	D

Explanation of Responses:
( 1)	This option exercise was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
( 2)	This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.
( 3)	The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.50 to $57.77. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
( 4)	The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.50 to $57.91. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.
( 5)	Shares held by KAS Grantor Retained Annuity Trust dated December 16, 2014 (the "GRAT"). The Reporting Person's spouse is a trustee and beneficiary of the GRAT.
( 6)	These options are fully vested in accordance with their terms.

Reporting Owners
Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Pugh Gordon G 852 WINTER ST. WALTHAM, MA 02451			SVP, COO & CRO, Alkermes, Inc.

Signatures
/s/ Jennifer Baptiste, attorney-in-fact for Gordon G. Pugh		12/19/2016
** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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