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Name | Symbol | Market | Type |
---|---|---|---|
Achilles Therapeutics PLC | NASDAQ:ACHL | NASDAQ | Depository Receipt |
Price Change | % Change | Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
-0.02 | -1.98% | 0.99 | 0.99 | 1.06 | 1.02 | 1.01 | 1.01 | 10,590 | 23:31:44 |
“Just after the close of the first quarter, we shared the interim Phase I/IIa data from our ongoing CHIRON and THETIS TIL-based cNeT clinical trials which have given us important mechanistic learnings about the factors driving durable engraftment and immune evasion at an antigen level. These data continue to inform the development of cNeT and potentially other modalities like neoantigen vaccines and TCR-T therapies,” said Dr Iraj Ali, Chief Executive Officer of Achilles Therapeutics. “We are evaluating cNeT persistence and clinical activity in patients with enhanced host conditioning, and we plan to report a meaningful data update in the second half of 2024. Our financial position remains strong with more than $112 million in cash, which will support operations through 2025, including the completion of the ongoing Phase I/IIa trials.”
Clinical and Business Highlights
Financial Highlights
2024 Focus
About Achilles TherapeuticsAchilles is a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. The Company has two ongoing Phase I/IIa trials, the CHIRON trial in patients with advanced non-small cell lung cancer (NSCLC) and the THETIS trial in patients with recurrent or metastatic melanoma. Achilles uses DNA sequencing data from each patient, together with its proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop precision T cell-based product candidates specifically targeting those clonal neoantigens.
Forward Looking StatementsThis press release contains express or implied forward-looking statements that are based on our management's belief and assumptions and on information currently available to our management. Forward-looking statements in this press release include, but are not limited to, statements regarding the timing of the Company’s clinical and translational data updates and the Company’s beliefs about recent data updates, and expectations related to the Company’s cash runway and operating expenses and capital expense requirements. Although we believe that the expectations reflected in these forward-looking statements are reasonable, these statements relate to future events or our future operational or financial performance, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should therefore not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.
For further information, please contact:
Investors:Meru AdvisorsLee M. Sternlstern@meruadvisors.com
Media:ICR ConsiliumSukaina Virji, Tracy Cheung, Dylan Wilks+44 (0) 203 709 5000achillestx@consilium-comms.com
ACHILLES THERAPEUTICS PLCCondensed Consolidated Balance Sheets (Unaudited)(in thousands, except share and per share amounts)(expressed in U.S. Dollars, unless otherwise stated) | ||||||||
March 31, | December 31, | |||||||
2024 | 2023 | |||||||
ASSETS | ||||||||
CURRENT ASSETS: | ||||||||
Cash and cash equivalents | $ | 112,322 | $ | 131,539 | ||||
Prepaid expenses and other current assets | 19,104 | 14,094 | ||||||
Total current assets | 131,426 | 145,633 | ||||||
Property and equipment, net | 8,107 | 9,171 | ||||||
Operating lease right of use assets | 3,965 | 4,372 | ||||||
Deferred tax assets | 41 | 41 | ||||||
Restricted cash | 33 | 33 | ||||||
Other assets | 2,169 | 2,206 | ||||||
Total non-current assets | 14,315 | 15,823 | ||||||
Total assets | $ | 145,741 | $ | 161,456 | ||||
LIABILITIES AND SHAREHOLDERS’ EQUITY | ||||||||
CURRENT LIABILITIES: | ||||||||
Accounts payable | $ | 3,313 | $ | 5,629 | ||||
Accrued expenses and other liabilities | 6,712 | 7,828 | ||||||
Operating lease liabilities - current | 3,628 | 3,539 | ||||||
Total current liabilities | 13,653 | 16,996 | ||||||
NON-CURRENT LIABILITIES: | ||||||||
Operating lease liabilities - non-current | 584 | 1,076 | ||||||
Other long-term liability | 1,156 | 1,015 | ||||||
Total non-current liabilities | 1,740 | 2,091 | ||||||
Total liabilities | 15,393 | 19,087 | ||||||
Commitments and contingencies | ||||||||
SHAREHOLDERS’ EQUITY: | ||||||||
Ordinary shares, £0.001 par value; 41,087,901 and 41,082,948 shares authorized, issued and outstanding at March 31, 2024 and December 31, 2023, respectively | 54 | 54 | ||||||
Deferred shares, £92,451.85 par value, one share authorized, issued and outstanding at March 31, 2024 and December 31, 2023, respectively | 128 | 128 | ||||||
Additional paid in capital | 416,602 | 415,210 | ||||||
Accumulated other comprehensive income | (14,210 | ) | (13,071 | ) | ||||
Accumulated deficit | (272,226 | ) | (259,952 | ) | ||||
Total shareholders’ equity | 130,348 | 142,369 | ||||||
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY | $ | 145,741 | $ | 161,456 |
ACHILLES THERAPEUTICS PLCCondensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)(in thousands, except share and per share amounts)(expressed in U.S. Dollars, unless otherwise stated) | ||||||||
Three Months Ended | ||||||||
March 31, | ||||||||
2024 | 2023 | |||||||
OPERATING EXPENSES: | ||||||||
Research and development | $ | 10,140 | $ | 13,868 | ||||
General and administrative | 4,159 | 4,685 | ||||||
Total operating expenses | 14,299 | 18,553 | ||||||
LOSS FROM OPERATIONS: | (14,299 | ) | (18,553 | ) | ||||
OTHER INCOME (EXPENSE), NET: | ||||||||
Other income (expense) | 2,002 | 1,091 | ||||||
Total other income (expense), net | 2,002 | 1,091 | ||||||
Loss before income taxes | (12,297 | ) | (17,462 | ) | ||||
Benefit (provision) for income taxes | 23 | (44 | ) | |||||
Net loss | (12,274 | ) | (17,506 | ) | ||||
Other comprehensive (loss) income: | ||||||||
Foreign exchange translation adjustment | (1,139 | ) | 3,977 | |||||
Comprehensive loss | $ | (13,413 | ) | $ | (13,529 | ) | ||
Net loss per share attributable to ordinary shareholders—basic and diluted | $ | (0.30 | ) | $ | (0.44 | ) | ||
Weighted average ordinary shares outstanding—basic and diluted | 40,281,407 | 39,732,186 |
1 Year Achilles Therapeutics Chart |
1 Month Achilles Therapeutics Chart |
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