Holding(s) in Company

RNS Number:2226Q
Alizyme PLC
26 September 2003

                                  SCHEDULE 10



                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company


Alizyme plc



2. Name of shareholder having a major interest


Universities Superannuation Scheme Limited



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18


Shareholder named at No.2



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


UK Smaller Companies Registered Under Chase Nominees Ltd (USS)
6,358,943 ordinary shares
UK Index Fund Registered Under Chase Nominees Ltd (USS)
444,000 ordinary shares



5. Number of shares / amount of stock acquired


N/A



6. Percentage of issued class


N/A



7. Number of shares / amount of stock disposed


500,000



8. Percentage of issued class


0.37 %



9. Class of security


Ordinary Shares of 2p each



10. Date of transaction


23 September 2003



11. Date company informed


25 September 2003



12. Total holding following this notification


6,802,943



13. Total percentage holding of issued class following this notification


4.97%



14. Any additional information






15. Name of contact and telephone number for queries


Mr Tim McCarthy 01223 896 000



16. Name and signature of authorised company official responsible for making
this notification


Tim McCarthy



Date of notification


26 September 2003



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