Share Purchase Plan

RNS Number:5577R
Skyepharma PLC
31 October 2003


Immediate Release                                                31 October 2003



                         SkyePharma PLC ("the Company")


As a result of transactions on 31 October 2003 by the SkyePharma PLC Share
Purchase Plan (an Inland Revenue approved all employee share purchase plan),
Michael Ashton and Donald Nicholson, directors of the Company, as trustees of
the Plan, became the beneficial owners of an additional 3,552 Ordinary Shares of
the Company, bringing the total held by the Plan to 86,798 Ordinary Shares of
the Company.


As a result the executive directors of the Company have the following additional
interests as a result of their personal participation in the Plan:-



                         Partnership          Matching          Total number of
                         Shares purchased     Shares awarded    Partnership and
                    on 31 October 2003   on 31 October     Matching Shares held
                     at #0.6475 per       2003 at #0.6475   on 31 October 2003.
                       share.               per share.

Ian Gowrie-Smith                  193               193                  3,950
Michael Ashton                    193               193                  9,380
Donald Nicholson                  193               193                  9,380


In accordance with the rules of the Plan these directors have been awarded the
Matching Shares on the basis of one Matching Share for each Partnership Share.


The beneficial ownership of the Matching Shares will pass to the directors in
three years time subject to continued employment and the retention of the
underlying Partnership Shares.



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