Share Purchase Plan

RNS Number:6256K
Skyepharma PLC
01 May 2003


Immediate Release                                                  1 May 2003


                         SkyePharma PLC ("the Company")

As a result of transactions on 30 April 2003 by the SkyePharma PLC Share
Purchase Plan (an Inland Revenue approved all employee share purchase plan),
Michael Ashton and Donald Nicholson, directors of the Company, as trustees of
the Plan, became the beneficial owners of an additional 4,495 Ordinary Shares of
the company, bringing the total held by the Plan to 56,784 Ordinary Shares of
the company.

As a result the executive directors of the Company have the following additional
interests as a result of their personal participation in the Plan:-

                                                                                                   
                         Partnership          Matching                       
                    Shares purchased    Shares awarded        Total number of
                    on 30 April 2003       on 30 April        Partnership and
                     at 51 pence per        2003 at 51   Matching Shares held
                               share   pence per share      on 30 April 2003.

Ian Gowrie-Smith                 245               245                  1,544
Michael Ashton                   245               245                  6,974
Donald Nicholson                 245               245                  6,974


In accordance with the rules of the Plan these directors have been awarded the
Matching Shares on the basis of one Matching Share for each Partnership Share.

The beneficial ownership of the Matching Shares will pass to the directors in
three years time subject to continued employment and the retention of the
underlying Partnership Shares.


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