Holding(s) in Company

RNS Number:2125I
Skyepharma PLC
03 March 2003


Immediate Release                                             3 March 2003





                         SkyePharma PLC ("the Company")





As a result of transactions on 28 February 2003 by the SkyePharma PLC Share
Purchase Plan (an Inland Revenue approved all employee share purchase plan),
Michael Ashton and Donald Nicholson, directors of the Company, as trustees of
the Plan, became the beneficial owners of an additional 5,439 ordinary shares of
the

company.



As a result the executive directors of the Company have the following additional
beneficial interests as a result of their personal participation in the Plan:-



Ian Gowrie-Smith - 277 Partnership Shares (ordinary shares in the Company).

Michael Ashton - 278 Partnership Shares (ordinary shares in the Company).

Donald Nicholson - 278 Partnership Shares (ordinary shares in the Company).



In accordance with the rules of the Plan these directors have been awarded
Matching Shares on the Basis of one Matching Share for each Partnership Share.



The beneficial ownership of these Matching Shares will pass to the directors in
three years time subject to continued employment and the retention of the
underlying Partnership Shares:-



Ian Gowrie-Smith - 277 Partnership Shares (ordinary shares in the Company)

Michael Ashton - 278 Matching Shares (ordinary shares in the Company).

Donald Nicholson - 278 Matching Shares (ordinary shares in the Company).



Partnership Shares were purchased at a price of 45 pence per share.

Matching Shares were awarded at a price of 45 pence per share.





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